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Serum Angiopoietin-Like Protein 2 Concentrations Are Independently Associated with Heart Failure.

Huang CL, Wu YW, Wu CC, Hwang JJ, Yang WS - PLoS ONE (2015)

Bottom Line: Compared with the control group subjects, serum ANGPTL2 concentrations were significantly higher in HF group patients.For the subjects with ANGPTL2 levels in the highest tertile, their risk of HF was about 2.97 fold (95% CI = 1.24-7.08, P = 0.01) higher than those in the lowest tertile.Our results demonstrate a higher circulating ANGPTL2 level in patients with HF, and the upregulating ANGPTL2 levels might be associated with metabolic derangements and inflammation.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

ABSTRACT

Objective: Angiopoietin-like protein 2 (ANGPTL2), which is mainly expressed from adipose tissue, is demonstrated to be involved in obesity, metabolic syndrome, and atherosclerosis. Because several adipocytokines are known to be associated with heart failure (HF), here we investigated the association of ANGPTL2 and HF in Taiwanese subjects.

Methods and results: A total of 170 symptomatic HF patients and 130 age- and sex-matched controls were enrolled from clinic. The echocardiography was analyzed in each patient, and stress myocardial perfusion study was performed for clinical suspicion of coronary artery disease. Detailed demographic information, medications, and biochemical data were recorded. Circulating adipocytokines, including tumor necrosis factor-alpha (TNF-α), adiponectin, adipocyte fatty acid-binding protein (A-FABP) and ANGPTL2, were analyzed. Compared with the control group subjects, serum ANGPTL2 concentrations were significantly higher in HF group patients. In correlation analyses, ANGPTL2 level was positively correlated to creatinine, fasting glucose, triglyceride, hsCRP, TNF-α, NT-proBNP and A-FABP levels, and negatively correlated with HDL-C and left ventricular ejection fraction. In multiple regression analysis, A-FABP, hsCRP, and HDL-C levels remained as independent predictors for ANGPTL2 level. To determine the association between serum ANGPTL2 concentrations and HF, multivariate logistic regression analyses were performed with subjects divided into tertiles by ANGPTL2 levels. For the subjects with ANGPTL2 levels in the highest tertile, their risk of HF was about 2.97 fold (95% CI = 1.24-7.08, P = 0.01) higher than those in the lowest tertile.

Conclusion: Our results demonstrate a higher circulating ANGPTL2 level in patients with HF, and the upregulating ANGPTL2 levels might be associated with metabolic derangements and inflammation.

No MeSH data available.


Related in: MedlinePlus

Scatter plot showing the relationship between serum ANGPTL2 levels and other clinical parameters.ANGPTL2 levels were positively correlated with hsCRP, TNF-α, A-FABP, NT-proBNP, and negatively correlated with eGFR and LVEF. (The Spearman correlation coefficients rho are presented).
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pone.0138678.g001: Scatter plot showing the relationship between serum ANGPTL2 levels and other clinical parameters.ANGPTL2 levels were positively correlated with hsCRP, TNF-α, A-FABP, NT-proBNP, and negatively correlated with eGFR and LVEF. (The Spearman correlation coefficients rho are presented).

Mentions: Table 2 shows the results of the Spearman correlation analysis between the ANGPTL2 levels and the other clinical parameters. Several important correlation plots were demonstrated in Fig 1. In all enrolled subjects, ANGPTL2 level was positively correlated with the creatinine, fasting glucose, HbA1c, triglyceride, hsCRP, TNF-α, and A-FABP levels, and negatively correlated with HDL-C level. The NT-proBNP level, an indicator of HF severity, was also positively correlated with ANGPTL2 level (rho = 0.34, P< 0.0001; Fig 1F). Among the echocardiographically derived parameters, ANGPTL2 level inversely correlated with LVEF (rho = −0.27, P< 0.0001; Fig 1D) but positively correlated with LVEDd, LVESd, and LAd. In order to determine which variables independently correlated with ANGPTL2 level, parameters that were significantly associated with ANGPTL2 level were included in a further multiple stepwise regression analysis. This revealed that HDL-C, A-FABP, and hsCRP levels were independently associated with ANGPTL2 level (Table 3).


Serum Angiopoietin-Like Protein 2 Concentrations Are Independently Associated with Heart Failure.

Huang CL, Wu YW, Wu CC, Hwang JJ, Yang WS - PLoS ONE (2015)

Scatter plot showing the relationship between serum ANGPTL2 levels and other clinical parameters.ANGPTL2 levels were positively correlated with hsCRP, TNF-α, A-FABP, NT-proBNP, and negatively correlated with eGFR and LVEF. (The Spearman correlation coefficients rho are presented).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4580406&req=5

pone.0138678.g001: Scatter plot showing the relationship between serum ANGPTL2 levels and other clinical parameters.ANGPTL2 levels were positively correlated with hsCRP, TNF-α, A-FABP, NT-proBNP, and negatively correlated with eGFR and LVEF. (The Spearman correlation coefficients rho are presented).
Mentions: Table 2 shows the results of the Spearman correlation analysis between the ANGPTL2 levels and the other clinical parameters. Several important correlation plots were demonstrated in Fig 1. In all enrolled subjects, ANGPTL2 level was positively correlated with the creatinine, fasting glucose, HbA1c, triglyceride, hsCRP, TNF-α, and A-FABP levels, and negatively correlated with HDL-C level. The NT-proBNP level, an indicator of HF severity, was also positively correlated with ANGPTL2 level (rho = 0.34, P< 0.0001; Fig 1F). Among the echocardiographically derived parameters, ANGPTL2 level inversely correlated with LVEF (rho = −0.27, P< 0.0001; Fig 1D) but positively correlated with LVEDd, LVESd, and LAd. In order to determine which variables independently correlated with ANGPTL2 level, parameters that were significantly associated with ANGPTL2 level were included in a further multiple stepwise regression analysis. This revealed that HDL-C, A-FABP, and hsCRP levels were independently associated with ANGPTL2 level (Table 3).

Bottom Line: Compared with the control group subjects, serum ANGPTL2 concentrations were significantly higher in HF group patients.For the subjects with ANGPTL2 levels in the highest tertile, their risk of HF was about 2.97 fold (95% CI = 1.24-7.08, P = 0.01) higher than those in the lowest tertile.Our results demonstrate a higher circulating ANGPTL2 level in patients with HF, and the upregulating ANGPTL2 levels might be associated with metabolic derangements and inflammation.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

ABSTRACT

Objective: Angiopoietin-like protein 2 (ANGPTL2), which is mainly expressed from adipose tissue, is demonstrated to be involved in obesity, metabolic syndrome, and atherosclerosis. Because several adipocytokines are known to be associated with heart failure (HF), here we investigated the association of ANGPTL2 and HF in Taiwanese subjects.

Methods and results: A total of 170 symptomatic HF patients and 130 age- and sex-matched controls were enrolled from clinic. The echocardiography was analyzed in each patient, and stress myocardial perfusion study was performed for clinical suspicion of coronary artery disease. Detailed demographic information, medications, and biochemical data were recorded. Circulating adipocytokines, including tumor necrosis factor-alpha (TNF-α), adiponectin, adipocyte fatty acid-binding protein (A-FABP) and ANGPTL2, were analyzed. Compared with the control group subjects, serum ANGPTL2 concentrations were significantly higher in HF group patients. In correlation analyses, ANGPTL2 level was positively correlated to creatinine, fasting glucose, triglyceride, hsCRP, TNF-α, NT-proBNP and A-FABP levels, and negatively correlated with HDL-C and left ventricular ejection fraction. In multiple regression analysis, A-FABP, hsCRP, and HDL-C levels remained as independent predictors for ANGPTL2 level. To determine the association between serum ANGPTL2 concentrations and HF, multivariate logistic regression analyses were performed with subjects divided into tertiles by ANGPTL2 levels. For the subjects with ANGPTL2 levels in the highest tertile, their risk of HF was about 2.97 fold (95% CI = 1.24-7.08, P = 0.01) higher than those in the lowest tertile.

Conclusion: Our results demonstrate a higher circulating ANGPTL2 level in patients with HF, and the upregulating ANGPTL2 levels might be associated with metabolic derangements and inflammation.

No MeSH data available.


Related in: MedlinePlus