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Prediction of background parenchymal enhancement on breast MRI using mammography, ultrasonography, and diffusion-weighted imaging.

Kawamura A, Satake H, Ishigaki S, Ikeda M, Kimura R, Shimamoto K, Naganawa S - Nagoya J Med Sci (2015)

Bottom Line: No significant correlation was found between mammographic density and BPE (p=0.085), whereas menopausal status (p=0.000), BP echotexture (p=0.000), and BP intensity on DWI (p= 0.000), and ADC values (p=0.000) showed significant correlations with BPE.Multivariate analysis showed that postmenopausal status was an independent predictor of minimal BPE (p=0.002, OR=3.743).BPE on breast MRI is associated with menopausal status and the findings of US and DWI.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya Japan.

ABSTRACT
This retrospective study assessed the effects of menopausal status and menstrual cycle on background parenchymal enhancement (BPE) of breast magnetic resonance imaging (MRI), and investigated whether the degree of BPE can be predicted by findings of mammography, ultrasonography (US), and diffusion-weighted MR imaging (DWI). There were 160 study patients (80 premenopausal, 80 postmenopausal). Degree of BPE was classified into minimal, mild, moderate, or marked. Mammographic density was classified into fatty, scattered, heterogeneously dense, and extremely dense. BP echotexture on US and BP intensity on DWI were visually classified as homogeneous or heterogeneous. Apparent diffusion coefficient (ADC) values of normal breast tissue were measured. Associations of the degree of BPE with menopausal status, menstrual cycle, or imaging features were evaluated by univariate and multivariate analyses. No significant correlation was found between mammographic density and BPE (p=0.085), whereas menopausal status (p=0.000), BP echotexture (p=0.000), and BP intensity on DWI (p= 0.000), and ADC values (p=0.000) showed significant correlations with BPE. Multivariate analysis showed that postmenopausal status was an independent predictor of minimal BPE (p=0.002, OR=3.743). In premenopausal women, there was no significant correlation between menstrual cycle and BPE, whereas BP echotexture was an independent predictor of whether BPE was less than mild or greater than moderate (p=0.001, OR=26.575). BPE on breast MRI is associated with menopausal status and the findings of US and DWI. Because premenopausal women with heterogeneous BP echotexture may be predicted to show moderate or marked BPE, scheduling of breast MRI should preferentially be adjusted to the menstrual cycle.

No MeSH data available.


Related in: MedlinePlus

Classification of BP intensity on DWI. Based on the increase of b values (50, 800, and 1500 s/mm2), normal breast tissue with a visually homogeneous decrease of signal intensity was defined as homogeneous BP intensity ((a) b value of 50s/mm2 ; (b) b value of 800s/mm2 ; (c) b value of 1500s/mm2), and normal breast tissue with a visually heterogeneous decrease of signal intensity was defined as homogeneous BP intensity ((d) b value of 50s/mm2 ; (e) b value of 800s/mm2 ; (f) b value of 1500s/mm2).
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fig2: Classification of BP intensity on DWI. Based on the increase of b values (50, 800, and 1500 s/mm2), normal breast tissue with a visually homogeneous decrease of signal intensity was defined as homogeneous BP intensity ((a) b value of 50s/mm2 ; (b) b value of 800s/mm2 ; (c) b value of 1500s/mm2), and normal breast tissue with a visually heterogeneous decrease of signal intensity was defined as homogeneous BP intensity ((d) b value of 50s/mm2 ; (e) b value of 800s/mm2 ; (f) b value of 1500s/mm2).

Mentions: For DWI-MRI, background parenchymal intensity (BP intensity) of normal breast tissue was visually classified as homogeneous or heterogeneous (Fig.2). Homogeneous BP intensity was defined as normal breast tissue with a visually homogeneous decrease of signal intensity according to the increase of b values. Heterogeneous BP intensity was defined as normal breast tissue with a visually heterogeneous decrease of signal intensity according to the increase of b values. For quantitative assessment of DWI, ADC values were measured by placing regions of interest (ROIs) on the axial images of the ADC maps at the level of the nipple. Three ROIs were drawn as large as possible in the breast gland to avoid the fat. One ROI was placed in the anterior (near the nipple) of the breast, and the other two ROIs were placed in lateral and medial posterior regions, as shown in Fig.3. If there was not sufficient breast tissue visible in a region of the breast, that case was omitted from the analysis. The average ADC values of the three regions were calculated.


Prediction of background parenchymal enhancement on breast MRI using mammography, ultrasonography, and diffusion-weighted imaging.

Kawamura A, Satake H, Ishigaki S, Ikeda M, Kimura R, Shimamoto K, Naganawa S - Nagoya J Med Sci (2015)

Classification of BP intensity on DWI. Based on the increase of b values (50, 800, and 1500 s/mm2), normal breast tissue with a visually homogeneous decrease of signal intensity was defined as homogeneous BP intensity ((a) b value of 50s/mm2 ; (b) b value of 800s/mm2 ; (c) b value of 1500s/mm2), and normal breast tissue with a visually heterogeneous decrease of signal intensity was defined as homogeneous BP intensity ((d) b value of 50s/mm2 ; (e) b value of 800s/mm2 ; (f) b value of 1500s/mm2).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4574330&req=5

fig2: Classification of BP intensity on DWI. Based on the increase of b values (50, 800, and 1500 s/mm2), normal breast tissue with a visually homogeneous decrease of signal intensity was defined as homogeneous BP intensity ((a) b value of 50s/mm2 ; (b) b value of 800s/mm2 ; (c) b value of 1500s/mm2), and normal breast tissue with a visually heterogeneous decrease of signal intensity was defined as homogeneous BP intensity ((d) b value of 50s/mm2 ; (e) b value of 800s/mm2 ; (f) b value of 1500s/mm2).
Mentions: For DWI-MRI, background parenchymal intensity (BP intensity) of normal breast tissue was visually classified as homogeneous or heterogeneous (Fig.2). Homogeneous BP intensity was defined as normal breast tissue with a visually homogeneous decrease of signal intensity according to the increase of b values. Heterogeneous BP intensity was defined as normal breast tissue with a visually heterogeneous decrease of signal intensity according to the increase of b values. For quantitative assessment of DWI, ADC values were measured by placing regions of interest (ROIs) on the axial images of the ADC maps at the level of the nipple. Three ROIs were drawn as large as possible in the breast gland to avoid the fat. One ROI was placed in the anterior (near the nipple) of the breast, and the other two ROIs were placed in lateral and medial posterior regions, as shown in Fig.3. If there was not sufficient breast tissue visible in a region of the breast, that case was omitted from the analysis. The average ADC values of the three regions were calculated.

Bottom Line: No significant correlation was found between mammographic density and BPE (p=0.085), whereas menopausal status (p=0.000), BP echotexture (p=0.000), and BP intensity on DWI (p= 0.000), and ADC values (p=0.000) showed significant correlations with BPE.Multivariate analysis showed that postmenopausal status was an independent predictor of minimal BPE (p=0.002, OR=3.743).BPE on breast MRI is associated with menopausal status and the findings of US and DWI.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya Japan.

ABSTRACT
This retrospective study assessed the effects of menopausal status and menstrual cycle on background parenchymal enhancement (BPE) of breast magnetic resonance imaging (MRI), and investigated whether the degree of BPE can be predicted by findings of mammography, ultrasonography (US), and diffusion-weighted MR imaging (DWI). There were 160 study patients (80 premenopausal, 80 postmenopausal). Degree of BPE was classified into minimal, mild, moderate, or marked. Mammographic density was classified into fatty, scattered, heterogeneously dense, and extremely dense. BP echotexture on US and BP intensity on DWI were visually classified as homogeneous or heterogeneous. Apparent diffusion coefficient (ADC) values of normal breast tissue were measured. Associations of the degree of BPE with menopausal status, menstrual cycle, or imaging features were evaluated by univariate and multivariate analyses. No significant correlation was found between mammographic density and BPE (p=0.085), whereas menopausal status (p=0.000), BP echotexture (p=0.000), and BP intensity on DWI (p= 0.000), and ADC values (p=0.000) showed significant correlations with BPE. Multivariate analysis showed that postmenopausal status was an independent predictor of minimal BPE (p=0.002, OR=3.743). In premenopausal women, there was no significant correlation between menstrual cycle and BPE, whereas BP echotexture was an independent predictor of whether BPE was less than mild or greater than moderate (p=0.001, OR=26.575). BPE on breast MRI is associated with menopausal status and the findings of US and DWI. Because premenopausal women with heterogeneous BP echotexture may be predicted to show moderate or marked BPE, scheduling of breast MRI should preferentially be adjusted to the menstrual cycle.

No MeSH data available.


Related in: MedlinePlus