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Neurocytoma arising from a mature ovary teratoma: a case report.

Yu JH, Yang LH, Lin XY, Dai SD, Qiu XS, Wang EH - Diagn Pathol (2015)

Bottom Line: Mature teratoma is a benign germ cell tumor commonly found in young women.The histological examinations showed mature epidermis, skin appendages, adipose and bone tissues in the tumor; microscopic foci of immature cartilage tissues were also found in some parts.In addition, massive solid sheets and uniform round tumor cells were found in the neuroectodermal tissues, with the formation of neuropil-like islands.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China. yujuanhan@foxmail.com.

ABSTRACT
Central neurocytoma/extraventricular neurocytoma is a central nervous system (CNS) tumor composed of uniform round cells with neuronal differentiation. The typical lesions of central neurocytoma/extraventricular neurocytoma are at the interventricular foramen of the lateral ventricles (central neurocytoma) or brain parenchyma (extraventricular neurocytoma). Mature teratoma is a benign germ cell tumor commonly found in young women. Herein, we report a 24-year-old female with neurocytoma in a mature teratoma of the right ovary. The histological examinations showed mature epidermis, skin appendages, adipose and bone tissues in the tumor; microscopic foci of immature cartilage tissues were also found in some parts. In addition, massive solid sheets and uniform round tumor cells were found in the neuroectodermal tissues, with the formation of neuropil-like islands. Immunohistochemical examinations showed that the tumor cells were synaptophysin- and NeuN-positive but GFAP-negative. Based on these findings, the woman was diagnosed with neurocytoma arising from mature ovary teratoma, with microscopic foci of immature cartilage tissues. This is the fourth case report of neurocytoma outside the CNS to date.

No MeSH data available.


Related in: MedlinePlus

a: Immunohistochemical staining for NeuN shows that the nuclei of the tumor cells are NeuN-positive; b: immunohistochemical staining for synaptophysin shows that the tumor cells and the neuropil-like islands are synaptophysin-positive; c: immunohistochemical staining for GFAP shows GFAP-negative tumor cells and trapped GFAP-positive reactive astrocytes; d: immunohistochemical staining for Ki-67 shows tumor cells with low proliferation index (about 2 %). a-d are at moderate magnification
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Fig3: a: Immunohistochemical staining for NeuN shows that the nuclei of the tumor cells are NeuN-positive; b: immunohistochemical staining for synaptophysin shows that the tumor cells and the neuropil-like islands are synaptophysin-positive; c: immunohistochemical staining for GFAP shows GFAP-negative tumor cells and trapped GFAP-positive reactive astrocytes; d: immunohistochemical staining for Ki-67 shows tumor cells with low proliferation index (about 2 %). a-d are at moderate magnification

Mentions: The mass was solid-cystic with a size of about 8.0 × 7.0 cm. Hair, teeth, and bone tissues were found inside the mass. The solid region of the mass was relatively fragile, and yellow-white in color. Histological examinations showed mature epidermis, cutaneous appendages, adipose, bone, and neuroectodermal tissues; microscopic foci of immature cartilage tissues were also found in one visual field (low magnification). In another region, solid sheets and monomorphic round tumor cells were found, with capillary-sized blood vessels among the cells; the boundaries with surrounding neuroectodermal tissues were clear. The density of the tumor cells varied: neuropil-like islands were found in the loose-textured areas with low cell density. While in the compacted areas, moderate density cells with uniform round nuclei and perinuclear halos with oligodendroglioma-like honeycomb appearance were found. Nuclear mitosis, angiogenesis, and necrosis were not found (Fig. 2). Immunohistochemical staining showed that the tumor cells were synaptophysin- and NeuN- positive but GFAP- and CK-negative. The neuropil-like islands were also synaptophysin-positive. Trapped GFAP-positive reactive astrocytes were seen. The Ki-67 proliferation index was about 2 % (Fig. 3). Based on these findings, the patient was diagnosed with neurocytoma arising from mature ovary teratoma, with microscopic foci of immature cartilage tissues. The follow-up is needed to evaluate the prognosis.Fig. 2


Neurocytoma arising from a mature ovary teratoma: a case report.

Yu JH, Yang LH, Lin XY, Dai SD, Qiu XS, Wang EH - Diagn Pathol (2015)

a: Immunohistochemical staining for NeuN shows that the nuclei of the tumor cells are NeuN-positive; b: immunohistochemical staining for synaptophysin shows that the tumor cells and the neuropil-like islands are synaptophysin-positive; c: immunohistochemical staining for GFAP shows GFAP-negative tumor cells and trapped GFAP-positive reactive astrocytes; d: immunohistochemical staining for Ki-67 shows tumor cells with low proliferation index (about 2 %). a-d are at moderate magnification
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4574217&req=5

Fig3: a: Immunohistochemical staining for NeuN shows that the nuclei of the tumor cells are NeuN-positive; b: immunohistochemical staining for synaptophysin shows that the tumor cells and the neuropil-like islands are synaptophysin-positive; c: immunohistochemical staining for GFAP shows GFAP-negative tumor cells and trapped GFAP-positive reactive astrocytes; d: immunohistochemical staining for Ki-67 shows tumor cells with low proliferation index (about 2 %). a-d are at moderate magnification
Mentions: The mass was solid-cystic with a size of about 8.0 × 7.0 cm. Hair, teeth, and bone tissues were found inside the mass. The solid region of the mass was relatively fragile, and yellow-white in color. Histological examinations showed mature epidermis, cutaneous appendages, adipose, bone, and neuroectodermal tissues; microscopic foci of immature cartilage tissues were also found in one visual field (low magnification). In another region, solid sheets and monomorphic round tumor cells were found, with capillary-sized blood vessels among the cells; the boundaries with surrounding neuroectodermal tissues were clear. The density of the tumor cells varied: neuropil-like islands were found in the loose-textured areas with low cell density. While in the compacted areas, moderate density cells with uniform round nuclei and perinuclear halos with oligodendroglioma-like honeycomb appearance were found. Nuclear mitosis, angiogenesis, and necrosis were not found (Fig. 2). Immunohistochemical staining showed that the tumor cells were synaptophysin- and NeuN- positive but GFAP- and CK-negative. The neuropil-like islands were also synaptophysin-positive. Trapped GFAP-positive reactive astrocytes were seen. The Ki-67 proliferation index was about 2 % (Fig. 3). Based on these findings, the patient was diagnosed with neurocytoma arising from mature ovary teratoma, with microscopic foci of immature cartilage tissues. The follow-up is needed to evaluate the prognosis.Fig. 2

Bottom Line: Mature teratoma is a benign germ cell tumor commonly found in young women.The histological examinations showed mature epidermis, skin appendages, adipose and bone tissues in the tumor; microscopic foci of immature cartilage tissues were also found in some parts.In addition, massive solid sheets and uniform round tumor cells were found in the neuroectodermal tissues, with the formation of neuropil-like islands.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China. yujuanhan@foxmail.com.

ABSTRACT
Central neurocytoma/extraventricular neurocytoma is a central nervous system (CNS) tumor composed of uniform round cells with neuronal differentiation. The typical lesions of central neurocytoma/extraventricular neurocytoma are at the interventricular foramen of the lateral ventricles (central neurocytoma) or brain parenchyma (extraventricular neurocytoma). Mature teratoma is a benign germ cell tumor commonly found in young women. Herein, we report a 24-year-old female with neurocytoma in a mature teratoma of the right ovary. The histological examinations showed mature epidermis, skin appendages, adipose and bone tissues in the tumor; microscopic foci of immature cartilage tissues were also found in some parts. In addition, massive solid sheets and uniform round tumor cells were found in the neuroectodermal tissues, with the formation of neuropil-like islands. Immunohistochemical examinations showed that the tumor cells were synaptophysin- and NeuN-positive but GFAP-negative. Based on these findings, the woman was diagnosed with neurocytoma arising from mature ovary teratoma, with microscopic foci of immature cartilage tissues. This is the fourth case report of neurocytoma outside the CNS to date.

No MeSH data available.


Related in: MedlinePlus