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Synthesis of novel dopamine derived multidirectional ligands from cyanuric chloride: structural and antimicrobial studies.

Koç ZE, Aladag MO, Uysal A - EXCLI J (2013)

Bottom Line: The results of the test were compared with ampicillin.It was determined that CCDOP1, CCDOP3 and DOP have significant antibacterial and antifungal activity.These three chemicals revealed strong antibacterial activity against the E. coli and S. aureus strains used in the study.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Science, Selçuk University, 42031 Konya, Turkey.

ABSTRACT
Two monopodal (2,4-dichloro-6-(3-hydroxytyramine)-1,3,5-triazine) and tripodal (2,4,6-(3-hydroxytyramine)-1,3,5-triazine) s-triazine derivatives were prepared through the reaction of cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) and 3-hydroxytyramine hydrochloride (dopamine hydrochloride). The structures of the compounds were identified by FT-IR, 1H NMR, 13C NMR, thermal analysis and elemental analysis. Their antimicrobial activities were carried out using the broth microdilution method in dimethyl sulfoxide (DMSO): Phosphate Buffered Saline (PBS) against eight bacteria and one yeast. The results of the test were compared with ampicillin. It was determined that CCDOP1, CCDOP3 and DOP have significant antibacterial and antifungal activity. These three chemicals revealed strong antibacterial activity against the E. coli and S. aureus strains used in the study. S. aureus was the most sensitive strain against dopamine hydrochloride and E. coli was the most sensitive bacteria against CCDOP1.

No MeSH data available.


Related in: MedlinePlus

Graphic of antimicrobial activity test results
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Figure 2: Graphic of antimicrobial activity test results

Mentions: In this study, the antimicrobial activities of CCDOP1, CCDOP3 and DOP were investigated by microbroth dilution method according to Maltaş et al. (2010[19]) against eight bacteria and one yeast. The obtained results are presented in Table 2(Tab. 2) and Figure 2(Fig. 2).


Synthesis of novel dopamine derived multidirectional ligands from cyanuric chloride: structural and antimicrobial studies.

Koç ZE, Aladag MO, Uysal A - EXCLI J (2013)

Graphic of antimicrobial activity test results
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4566919&req=5

Figure 2: Graphic of antimicrobial activity test results
Mentions: In this study, the antimicrobial activities of CCDOP1, CCDOP3 and DOP were investigated by microbroth dilution method according to Maltaş et al. (2010[19]) against eight bacteria and one yeast. The obtained results are presented in Table 2(Tab. 2) and Figure 2(Fig. 2).

Bottom Line: The results of the test were compared with ampicillin.It was determined that CCDOP1, CCDOP3 and DOP have significant antibacterial and antifungal activity.These three chemicals revealed strong antibacterial activity against the E. coli and S. aureus strains used in the study.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Science, Selçuk University, 42031 Konya, Turkey.

ABSTRACT
Two monopodal (2,4-dichloro-6-(3-hydroxytyramine)-1,3,5-triazine) and tripodal (2,4,6-(3-hydroxytyramine)-1,3,5-triazine) s-triazine derivatives were prepared through the reaction of cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) and 3-hydroxytyramine hydrochloride (dopamine hydrochloride). The structures of the compounds were identified by FT-IR, 1H NMR, 13C NMR, thermal analysis and elemental analysis. Their antimicrobial activities were carried out using the broth microdilution method in dimethyl sulfoxide (DMSO): Phosphate Buffered Saline (PBS) against eight bacteria and one yeast. The results of the test were compared with ampicillin. It was determined that CCDOP1, CCDOP3 and DOP have significant antibacterial and antifungal activity. These three chemicals revealed strong antibacterial activity against the E. coli and S. aureus strains used in the study. S. aureus was the most sensitive strain against dopamine hydrochloride and E. coli was the most sensitive bacteria against CCDOP1.

No MeSH data available.


Related in: MedlinePlus