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Zwitterionic Nanofibers of Super-Glue for Transparent and Biocompatible Multi-Purpose Coatings.

Mele E, Heredia-Guerrero JA, Bayer IS, Ciofani G, Genchi GG, Ceseracciu L, Davis A, Papadopoulou EL, Barthel MJ, Marini L, Ruffilli R, Athanassiou A - Sci Rep (2015)

Bottom Line: The resulting fibrous networks are thermally treated on glass in order to create transparent coatings whose superficial morphology recalls the organization of the initial electrospun mats.The inherent texture of the coatings positively affects their biocompatibility.In fact, they are able to promote the proliferation and differentiation of myoblast stem cells.

View Article: PubMed Central - PubMed

Affiliation: Smart Materials, Istituto Italiano di Tecnologia (IIT), via Morego 30, 16163 Genoa, Italy.

ABSTRACT
Here we show that macrozwitterions of poly(ethyl 2-cyanoacrylate), commonly called Super Glue, can easily assemble into long and well defined fibers by electrospinning. The resulting fibrous networks are thermally treated on glass in order to create transparent coatings whose superficial morphology recalls the organization of the initial electrospun mats. These textured coatings are characterized by low liquid adhesion and anti-staining performance. Furthermore, the low friction coefficient and excellent scratch resistance make them attractive as solid lubricants. The inherent texture of the coatings positively affects their biocompatibility. In fact, they are able to promote the proliferation and differentiation of myoblast stem cells. Optically-transparent and biocompatible coatings that simultaneously possess characteristics of low water contact angle hysteresis, low friction and mechanical robustness can find application in a wide range of technological sectors, from the construction and automotive industries to electronic and biomedical devices.

No MeSH data available.


Related in: MedlinePlus

Zwitterionic PECA fibers.(a) Photographs of the different stages of preparation of the DMSO-modified ECA: from left to right, initial commercial liquid ECA, PECA gel after mixing ECA with DMSO, liquid solution of zwitterionic PECA in acetone. Scale bar = 0.5 cm. SEM images of the PECA fibers electrospun from acetone solutions at concentration of (b) 2.5% v/v and (c) 5.0% v/v.
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f1: Zwitterionic PECA fibers.(a) Photographs of the different stages of preparation of the DMSO-modified ECA: from left to right, initial commercial liquid ECA, PECA gel after mixing ECA with DMSO, liquid solution of zwitterionic PECA in acetone. Scale bar = 0.5 cm. SEM images of the PECA fibers electrospun from acetone solutions at concentration of (b) 2.5% v/v and (c) 5.0% v/v.

Mentions: In its initial formulation ECA is a transparent liquid with an average viscosity of 0.1 Pa·s (photograph on the left, Fig. 1a). Upon mixing it with DMSO at 1:1 volume ratio, an exothermic reaction took place with a consequent fast increment of the solution viscosity and the formation of a gelatinized system (photograph in the middle, Fig. 1a). This gel was thinned by acetone to obtain a crystal-clear solution (photograph on the right, Fig. 1a). In particular, DMSO-modified ECA solutions in acetone were prepared at concentrations of 2.5, 5.0 and 10.0% v/v for electrospinning. In contrast with the starting ethyl 2-cyanoacrylate, the polymer derived by reacting ECA with DMSO could be easily electrospun even with low applied voltages (5 kV). The morphology of the produced PECA fibers was investigated by scanning electron microscope (SEM). The fibers that were electrospun from DMSO-ECA acetone solutions at the lowest concentration (2.5% v/v) exhibited a non-uniform diameter throughout their length, since bead-like structures were present (Fig. 1b). In order to improve the size uniformity of the fibers, DMSO-ECA acetone solutions at a concentration of 5.0% v/v were prepared. In this way, networks of long and well-defined fibers having a diameter of (473 ± 58) nm were produced over large area, without the presence of beaded features (Fig. 1c). Fibers with bigger diameter were electrospun by further increasing the concentration of the DMSO-ECA polymer in acetone (10.0% v/v, Figure S1 in the Supplementary Information).


Zwitterionic Nanofibers of Super-Glue for Transparent and Biocompatible Multi-Purpose Coatings.

Mele E, Heredia-Guerrero JA, Bayer IS, Ciofani G, Genchi GG, Ceseracciu L, Davis A, Papadopoulou EL, Barthel MJ, Marini L, Ruffilli R, Athanassiou A - Sci Rep (2015)

Zwitterionic PECA fibers.(a) Photographs of the different stages of preparation of the DMSO-modified ECA: from left to right, initial commercial liquid ECA, PECA gel after mixing ECA with DMSO, liquid solution of zwitterionic PECA in acetone. Scale bar = 0.5 cm. SEM images of the PECA fibers electrospun from acetone solutions at concentration of (b) 2.5% v/v and (c) 5.0% v/v.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4566136&req=5

f1: Zwitterionic PECA fibers.(a) Photographs of the different stages of preparation of the DMSO-modified ECA: from left to right, initial commercial liquid ECA, PECA gel after mixing ECA with DMSO, liquid solution of zwitterionic PECA in acetone. Scale bar = 0.5 cm. SEM images of the PECA fibers electrospun from acetone solutions at concentration of (b) 2.5% v/v and (c) 5.0% v/v.
Mentions: In its initial formulation ECA is a transparent liquid with an average viscosity of 0.1 Pa·s (photograph on the left, Fig. 1a). Upon mixing it with DMSO at 1:1 volume ratio, an exothermic reaction took place with a consequent fast increment of the solution viscosity and the formation of a gelatinized system (photograph in the middle, Fig. 1a). This gel was thinned by acetone to obtain a crystal-clear solution (photograph on the right, Fig. 1a). In particular, DMSO-modified ECA solutions in acetone were prepared at concentrations of 2.5, 5.0 and 10.0% v/v for electrospinning. In contrast with the starting ethyl 2-cyanoacrylate, the polymer derived by reacting ECA with DMSO could be easily electrospun even with low applied voltages (5 kV). The morphology of the produced PECA fibers was investigated by scanning electron microscope (SEM). The fibers that were electrospun from DMSO-ECA acetone solutions at the lowest concentration (2.5% v/v) exhibited a non-uniform diameter throughout their length, since bead-like structures were present (Fig. 1b). In order to improve the size uniformity of the fibers, DMSO-ECA acetone solutions at a concentration of 5.0% v/v were prepared. In this way, networks of long and well-defined fibers having a diameter of (473 ± 58) nm were produced over large area, without the presence of beaded features (Fig. 1c). Fibers with bigger diameter were electrospun by further increasing the concentration of the DMSO-ECA polymer in acetone (10.0% v/v, Figure S1 in the Supplementary Information).

Bottom Line: The resulting fibrous networks are thermally treated on glass in order to create transparent coatings whose superficial morphology recalls the organization of the initial electrospun mats.The inherent texture of the coatings positively affects their biocompatibility.In fact, they are able to promote the proliferation and differentiation of myoblast stem cells.

View Article: PubMed Central - PubMed

Affiliation: Smart Materials, Istituto Italiano di Tecnologia (IIT), via Morego 30, 16163 Genoa, Italy.

ABSTRACT
Here we show that macrozwitterions of poly(ethyl 2-cyanoacrylate), commonly called Super Glue, can easily assemble into long and well defined fibers by electrospinning. The resulting fibrous networks are thermally treated on glass in order to create transparent coatings whose superficial morphology recalls the organization of the initial electrospun mats. These textured coatings are characterized by low liquid adhesion and anti-staining performance. Furthermore, the low friction coefficient and excellent scratch resistance make them attractive as solid lubricants. The inherent texture of the coatings positively affects their biocompatibility. In fact, they are able to promote the proliferation and differentiation of myoblast stem cells. Optically-transparent and biocompatible coatings that simultaneously possess characteristics of low water contact angle hysteresis, low friction and mechanical robustness can find application in a wide range of technological sectors, from the construction and automotive industries to electronic and biomedical devices.

No MeSH data available.


Related in: MedlinePlus