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Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals.

Otsuki T, Maeda S, Mukai J, Ohki M, Nakanishi M, Yoshikawa T - J Clin Biochem Nutr (2015)

Bottom Line: Plasma sLOX-1 concentration was correlated with baPWV (r = 0.288, p = 0.0005).Multiple logistic regression demonstrated that plasma sLOX-1 concentration was independently associated with elevated baPWV (≥14.0 m/s; odds ratio, 1.01; 95% confidence interval, 1.00-1.03; p = 0.03).These results suggest that LOX-1 is associated with arterial stiffness.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Sport and Health Sciences, Ryutsu Keizai University, 120 Ryugasaki, Ibaraki 301-8555, Japan.

ABSTRACT
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in vascular endothelial function. Vascular endothelial function is a potent regulator of arterial stiffness, an independent risk factor for cardiovascular disease. However, it is unknown whether LOX-1 is associated with arterial stiffness. Plasma concentrations of soluble LOX-1 (sLOX-1) and brachial-ankle pulse wave velocity (baPWV, an index of arterial stiffness) were measured in 143 individuals between 51 and 83 years of age. Plasma sLOX-1 concentration was correlated with baPWV (r = 0.288, p = 0.0005). In stepwise regression analysis, plasma sLOX-1 concentration was associated with baPWV, after adjusting for age; body mass index; blood pressure; heart rate; blood levels of cholesterol, triglycerides, glucose, hemoglobin A1c, and insulin; sex; and use of antihypertensives, lipid-lowering agents, and other medications (R (2) = 0.575, p<0.0001). Multiple logistic regression demonstrated that plasma sLOX-1 concentration was independently associated with elevated baPWV (≥14.0 m/s; odds ratio, 1.01; 95% confidence interval, 1.00-1.03; p = 0.03). These results suggest that LOX-1 is associated with arterial stiffness.

No MeSH data available.


Related in: MedlinePlus

Correlation between plasma concentration of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) and brachial-ankle pulse wave velocity (baPWV).
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Related In: Results  -  Collection


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Figure 1: Correlation between plasma concentration of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) and brachial-ankle pulse wave velocity (baPWV).

Mentions: BaPWV was correlated with plasma sLOX-1 concentration (Fig. 1), age (r = 0.466, p<0.0001), systolic blood pressure (SBP; r = 0.615, p<0.0001), diastolic blood pressure (DBP; r = 0.402, p<0.0001), heart rate (HR; r = 0.238, p = 0.004), plasma glucose concentration (r = 0.274, p = 0.0009), and hemoglobin A1c (r = 0.261, p = 0.001). BaPWV was not correlated with body mass index (BMI) and serum concentrations of LDL, HDL, triglycerides, and insulin. Plasma sLOX-1 concentration, age, SBP, and HR were identified as independent predictors of baPWV in the stepwise regression analysis that included sex (male = 0, female = 1); use of antihypertensives, lipid-lowering agents, and other medications (yes = 0, no = 1); age; BMI; SBP; DBP; HR; and blood levels of sLOX-1, LDL, HDL, triglycerides, glucose, hemoglobin A1c, and insulin (Table 2).


Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals.

Otsuki T, Maeda S, Mukai J, Ohki M, Nakanishi M, Yoshikawa T - J Clin Biochem Nutr (2015)

Correlation between plasma concentration of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) and brachial-ankle pulse wave velocity (baPWV).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4566029&req=5

Figure 1: Correlation between plasma concentration of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) and brachial-ankle pulse wave velocity (baPWV).
Mentions: BaPWV was correlated with plasma sLOX-1 concentration (Fig. 1), age (r = 0.466, p<0.0001), systolic blood pressure (SBP; r = 0.615, p<0.0001), diastolic blood pressure (DBP; r = 0.402, p<0.0001), heart rate (HR; r = 0.238, p = 0.004), plasma glucose concentration (r = 0.274, p = 0.0009), and hemoglobin A1c (r = 0.261, p = 0.001). BaPWV was not correlated with body mass index (BMI) and serum concentrations of LDL, HDL, triglycerides, and insulin. Plasma sLOX-1 concentration, age, SBP, and HR were identified as independent predictors of baPWV in the stepwise regression analysis that included sex (male = 0, female = 1); use of antihypertensives, lipid-lowering agents, and other medications (yes = 0, no = 1); age; BMI; SBP; DBP; HR; and blood levels of sLOX-1, LDL, HDL, triglycerides, glucose, hemoglobin A1c, and insulin (Table 2).

Bottom Line: Plasma sLOX-1 concentration was correlated with baPWV (r = 0.288, p = 0.0005).Multiple logistic regression demonstrated that plasma sLOX-1 concentration was independently associated with elevated baPWV (≥14.0 m/s; odds ratio, 1.01; 95% confidence interval, 1.00-1.03; p = 0.03).These results suggest that LOX-1 is associated with arterial stiffness.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Sport and Health Sciences, Ryutsu Keizai University, 120 Ryugasaki, Ibaraki 301-8555, Japan.

ABSTRACT
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in vascular endothelial function. Vascular endothelial function is a potent regulator of arterial stiffness, an independent risk factor for cardiovascular disease. However, it is unknown whether LOX-1 is associated with arterial stiffness. Plasma concentrations of soluble LOX-1 (sLOX-1) and brachial-ankle pulse wave velocity (baPWV, an index of arterial stiffness) were measured in 143 individuals between 51 and 83 years of age. Plasma sLOX-1 concentration was correlated with baPWV (r = 0.288, p = 0.0005). In stepwise regression analysis, plasma sLOX-1 concentration was associated with baPWV, after adjusting for age; body mass index; blood pressure; heart rate; blood levels of cholesterol, triglycerides, glucose, hemoglobin A1c, and insulin; sex; and use of antihypertensives, lipid-lowering agents, and other medications (R (2) = 0.575, p<0.0001). Multiple logistic regression demonstrated that plasma sLOX-1 concentration was independently associated with elevated baPWV (≥14.0 m/s; odds ratio, 1.01; 95% confidence interval, 1.00-1.03; p = 0.03). These results suggest that LOX-1 is associated with arterial stiffness.

No MeSH data available.


Related in: MedlinePlus