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Bioimpedance Detection of Oral Lichen Planus Used as Preneoplastic Model.

Tatullo M, Marrelli M, Amantea M, Paduano F, Santacroce L, Gentile S, Scacco S - J Cancer (2015)

Bottom Line: We observed a significant increase of Z and a significant decrease of θ values in correspondence of OLP lesions compared to healthy oral mucosa, and a marked decrease of Z values in correspondence of erosive OLP lesions.These results provide evidence of the usefulness of bioimpedance assay for the characterization of healthy and clinically OLP affected mucosa.Bioimpedance is a valid aid in the early detection and clinical monitoring of the suspicious lesions which could lead to a potentially malignant evolution.

View Article: PubMed Central - PubMed

Affiliation: Unit of Maxillofacial Surgery, Calabrodental, Crotone, Italy ; 2. Tecnologica Research Institute, Biomedical Section, Crotone, Italy.

ABSTRACT

Introduction: Bioimpedance is a measure of the electrical properties of biological tissues. In the last two decades bioimpedance has been successfully introduced in clinical diagnosis of cancer. It has been demonstrated that tumoral tissues often show lower bioimpedance values than healthy tissues. The aim of this work is to assess the bioimpedentiometric differences between healthy and Oral Lichen Planus (OLP) affected oral mucosa, taking attention to the erosive form which may represent a potential pre-cancerous condition.

Methods: 52 patients affected by OLP were recruited for bioimpedance examination of oral mucosa. Four electrical properties, resistance (R), reactance (Xc), phase angle (θ) and impedance (Z) of the tongue and of the intraoral mucosa, were measured.

Results: We observed a significant increase of Z and a significant decrease of θ values in correspondence of OLP lesions compared to healthy oral mucosa, and a marked decrease of Z values in correspondence of erosive OLP lesions.

Conclusions: These results provide evidence of the usefulness of bioimpedance assay for the characterization of healthy and clinically OLP affected mucosa. Bioimpedance is a valid aid in the early detection and clinical monitoring of the suspicious lesions which could lead to a potentially malignant evolution. The present research article is a valuable addition to the scientific literature of cancer prevention, and our findings can be considered extremely encouraging as they represent the initial step for a more wide clinical study for better define the different cut-off values in the different precancerous conditions occurring in the oral mucosa.

No MeSH data available.


Related in: MedlinePlus

BIOIMPEDANCE LIMIT VALUES FOR OLP LESIONS NEOPLASTIC POTENTIAL. A: patient affected by OLP on the intraoral mucosa; B: white arrows indicate 1) healthy oral mucosa, 2) reticular OLP lesions, 3) hyperkeratotic plaques, 4) erosive OLP lesions; C: the hatched areas correspond to different portions of the intraoral mucosa affected by reticular (2), hyperkeratotic (3) and erosive (4) OLP lesions. The colors represent the intensity of the Z value registered in correspondence of each specific area as indicated above. On the chromatic scale below are reported the Z values observed for each OLP lesion analyzed in the present study, as well as for healthy intraoral mucosa. We also added the Z value reported for cancerous tongue tissue by Ching et al. 1.
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Figure 3: BIOIMPEDANCE LIMIT VALUES FOR OLP LESIONS NEOPLASTIC POTENTIAL. A: patient affected by OLP on the intraoral mucosa; B: white arrows indicate 1) healthy oral mucosa, 2) reticular OLP lesions, 3) hyperkeratotic plaques, 4) erosive OLP lesions; C: the hatched areas correspond to different portions of the intraoral mucosa affected by reticular (2), hyperkeratotic (3) and erosive (4) OLP lesions. The colors represent the intensity of the Z value registered in correspondence of each specific area as indicated above. On the chromatic scale below are reported the Z values observed for each OLP lesion analyzed in the present study, as well as for healthy intraoral mucosa. We also added the Z value reported for cancerous tongue tissue by Ching et al. 1.

Mentions: Furthermore, according to the results above described, we spotted different ranges of Z values, which indicate the electrical peculiarities characterizing the different forms of OLP lesions occurring on the oral mucosa. We indicated these ranges in Table 2 and we represented them graphically in Figure 3, with a color-code scale associated. Finally, the validity and the sensitivity of our bioimpedance model, as a good predictor of different forms of OLP lesions, were confirmed by the evaluation of the area under the ROC curve (AUC=0.89), as indicated in Table 2.


Bioimpedance Detection of Oral Lichen Planus Used as Preneoplastic Model.

Tatullo M, Marrelli M, Amantea M, Paduano F, Santacroce L, Gentile S, Scacco S - J Cancer (2015)

BIOIMPEDANCE LIMIT VALUES FOR OLP LESIONS NEOPLASTIC POTENTIAL. A: patient affected by OLP on the intraoral mucosa; B: white arrows indicate 1) healthy oral mucosa, 2) reticular OLP lesions, 3) hyperkeratotic plaques, 4) erosive OLP lesions; C: the hatched areas correspond to different portions of the intraoral mucosa affected by reticular (2), hyperkeratotic (3) and erosive (4) OLP lesions. The colors represent the intensity of the Z value registered in correspondence of each specific area as indicated above. On the chromatic scale below are reported the Z values observed for each OLP lesion analyzed in the present study, as well as for healthy intraoral mucosa. We also added the Z value reported for cancerous tongue tissue by Ching et al. 1.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4565846&req=5

Figure 3: BIOIMPEDANCE LIMIT VALUES FOR OLP LESIONS NEOPLASTIC POTENTIAL. A: patient affected by OLP on the intraoral mucosa; B: white arrows indicate 1) healthy oral mucosa, 2) reticular OLP lesions, 3) hyperkeratotic plaques, 4) erosive OLP lesions; C: the hatched areas correspond to different portions of the intraoral mucosa affected by reticular (2), hyperkeratotic (3) and erosive (4) OLP lesions. The colors represent the intensity of the Z value registered in correspondence of each specific area as indicated above. On the chromatic scale below are reported the Z values observed for each OLP lesion analyzed in the present study, as well as for healthy intraoral mucosa. We also added the Z value reported for cancerous tongue tissue by Ching et al. 1.
Mentions: Furthermore, according to the results above described, we spotted different ranges of Z values, which indicate the electrical peculiarities characterizing the different forms of OLP lesions occurring on the oral mucosa. We indicated these ranges in Table 2 and we represented them graphically in Figure 3, with a color-code scale associated. Finally, the validity and the sensitivity of our bioimpedance model, as a good predictor of different forms of OLP lesions, were confirmed by the evaluation of the area under the ROC curve (AUC=0.89), as indicated in Table 2.

Bottom Line: We observed a significant increase of Z and a significant decrease of θ values in correspondence of OLP lesions compared to healthy oral mucosa, and a marked decrease of Z values in correspondence of erosive OLP lesions.These results provide evidence of the usefulness of bioimpedance assay for the characterization of healthy and clinically OLP affected mucosa.Bioimpedance is a valid aid in the early detection and clinical monitoring of the suspicious lesions which could lead to a potentially malignant evolution.

View Article: PubMed Central - PubMed

Affiliation: Unit of Maxillofacial Surgery, Calabrodental, Crotone, Italy ; 2. Tecnologica Research Institute, Biomedical Section, Crotone, Italy.

ABSTRACT

Introduction: Bioimpedance is a measure of the electrical properties of biological tissues. In the last two decades bioimpedance has been successfully introduced in clinical diagnosis of cancer. It has been demonstrated that tumoral tissues often show lower bioimpedance values than healthy tissues. The aim of this work is to assess the bioimpedentiometric differences between healthy and Oral Lichen Planus (OLP) affected oral mucosa, taking attention to the erosive form which may represent a potential pre-cancerous condition.

Methods: 52 patients affected by OLP were recruited for bioimpedance examination of oral mucosa. Four electrical properties, resistance (R), reactance (Xc), phase angle (θ) and impedance (Z) of the tongue and of the intraoral mucosa, were measured.

Results: We observed a significant increase of Z and a significant decrease of θ values in correspondence of OLP lesions compared to healthy oral mucosa, and a marked decrease of Z values in correspondence of erosive OLP lesions.

Conclusions: These results provide evidence of the usefulness of bioimpedance assay for the characterization of healthy and clinically OLP affected mucosa. Bioimpedance is a valid aid in the early detection and clinical monitoring of the suspicious lesions which could lead to a potentially malignant evolution. The present research article is a valuable addition to the scientific literature of cancer prevention, and our findings can be considered extremely encouraging as they represent the initial step for a more wide clinical study for better define the different cut-off values in the different precancerous conditions occurring in the oral mucosa.

No MeSH data available.


Related in: MedlinePlus