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Oxytocin modulates meta-mood as a function of age and sex.

Ebner NC, Horta M, Lin T, Feifel D, Fischer H, Cohen RA - Front Aging Neurosci (2015)

Bottom Line: Going beyond previous work that almost exclusively examined young men and perceptions of emotions in others, the current study investigated effects of intranasal oxytocin on meta-mood in young and older men and women.Oxytocin relative to placebo enhanced meta-mood in young female participants but reduced it in older female participants.This pattern of findings supports an age- and sex-differential modulatory function of the neuropeptide oxytocin on meta-mood, possibly associated with neurobiological differences with age and sex.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Florida Gainesville, FL, USA ; Cognitive Aging and Memory Program, Clinical Translational Research Program (CAM-CTRP), Institute on Aging, Department of Aging and Geriatric Research, University of Florida Gainesville, FL, USA.

ABSTRACT
Attending to and understanding one's own feelings are components of meta-mood and constitute important socio-affective skills across the entire lifespan. Growing evidence suggests a modulatory role of the neuropeptide oxytocin on various socio-affective processes. Going beyond previous work that almost exclusively examined young men and perceptions of emotions in others, the current study investigated effects of intranasal oxytocin on meta-mood in young and older men and women. In a double-blind between-group design, participants were randomly assigned to self-administer either intranasal oxytocin or a placebo before responding to items from the Trait Meta-Mood Scale (TMMS) about attention to feelings and clarity of feelings. In contrast to older women, oxytocin relative to placebo increased attention to feelings in older men. Oxytocin relative to placebo enhanced meta-mood in young female participants but reduced it in older female participants. This pattern of findings supports an age- and sex-differential modulatory function of the neuropeptide oxytocin on meta-mood, possibly associated with neurobiological differences with age and sex.

No MeSH data available.


Participant scores in the attention to feelings subscale of the TMMS in the oxytocin and placebo conditions, as a function of participant age and sex, with error bars representing mean standard errors. *p > 0.05.
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Figure 1: Participant scores in the attention to feelings subscale of the TMMS in the oxytocin and placebo conditions, as a function of participant age and sex, with error bars representing mean standard errors. *p > 0.05.

Mentions: For attention, the effect of age (F(1,90) = 9.23, p = 0.00, = 0.09), sex (F(1,90) = 4.46, p = 0.04, = 0.05), and the age × sex × treatment interaction (F(1,90) = 5.17, p = 0.02, = 0.06), were significant. That is, overall, young (M = 3.71, SD = 0.68) compared to older (M = 3.30, SD = 0.66) participants, as well as women (M = 3.65, SD = 0.71) compared to men (M = 3.37, SD = 0.65) reported more attention to feelings. However, as depicted in Figure 1, the significant three-way interaction qualified these main effects. In particular, follow-up analyses conducted separately in young and older participants showed that the sex × treatment interaction was not significant in young participants (F(1,42) = 1.05, p = 0.31, = 0.02), while it was significant in older participants (F(1,48) = 5.09, p = 0.03, = 0.10): in contrast to older women, oxytocin relative to placebo increased attention to feelings in older men. In addition, in women there was a significant age × treatment interaction (F(1,47) = 4.08, p = 0.049, = 0.080), in that in young women oxytocin relative to placebo enhanced attention to feelings, while in older women oxytocin relative to placebo reduced it. There was no age × treatment interaction among men.


Oxytocin modulates meta-mood as a function of age and sex.

Ebner NC, Horta M, Lin T, Feifel D, Fischer H, Cohen RA - Front Aging Neurosci (2015)

Participant scores in the attention to feelings subscale of the TMMS in the oxytocin and placebo conditions, as a function of participant age and sex, with error bars representing mean standard errors. *p > 0.05.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4565056&req=5

Figure 1: Participant scores in the attention to feelings subscale of the TMMS in the oxytocin and placebo conditions, as a function of participant age and sex, with error bars representing mean standard errors. *p > 0.05.
Mentions: For attention, the effect of age (F(1,90) = 9.23, p = 0.00, = 0.09), sex (F(1,90) = 4.46, p = 0.04, = 0.05), and the age × sex × treatment interaction (F(1,90) = 5.17, p = 0.02, = 0.06), were significant. That is, overall, young (M = 3.71, SD = 0.68) compared to older (M = 3.30, SD = 0.66) participants, as well as women (M = 3.65, SD = 0.71) compared to men (M = 3.37, SD = 0.65) reported more attention to feelings. However, as depicted in Figure 1, the significant three-way interaction qualified these main effects. In particular, follow-up analyses conducted separately in young and older participants showed that the sex × treatment interaction was not significant in young participants (F(1,42) = 1.05, p = 0.31, = 0.02), while it was significant in older participants (F(1,48) = 5.09, p = 0.03, = 0.10): in contrast to older women, oxytocin relative to placebo increased attention to feelings in older men. In addition, in women there was a significant age × treatment interaction (F(1,47) = 4.08, p = 0.049, = 0.080), in that in young women oxytocin relative to placebo enhanced attention to feelings, while in older women oxytocin relative to placebo reduced it. There was no age × treatment interaction among men.

Bottom Line: Going beyond previous work that almost exclusively examined young men and perceptions of emotions in others, the current study investigated effects of intranasal oxytocin on meta-mood in young and older men and women.Oxytocin relative to placebo enhanced meta-mood in young female participants but reduced it in older female participants.This pattern of findings supports an age- and sex-differential modulatory function of the neuropeptide oxytocin on meta-mood, possibly associated with neurobiological differences with age and sex.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Florida Gainesville, FL, USA ; Cognitive Aging and Memory Program, Clinical Translational Research Program (CAM-CTRP), Institute on Aging, Department of Aging and Geriatric Research, University of Florida Gainesville, FL, USA.

ABSTRACT
Attending to and understanding one's own feelings are components of meta-mood and constitute important socio-affective skills across the entire lifespan. Growing evidence suggests a modulatory role of the neuropeptide oxytocin on various socio-affective processes. Going beyond previous work that almost exclusively examined young men and perceptions of emotions in others, the current study investigated effects of intranasal oxytocin on meta-mood in young and older men and women. In a double-blind between-group design, participants were randomly assigned to self-administer either intranasal oxytocin or a placebo before responding to items from the Trait Meta-Mood Scale (TMMS) about attention to feelings and clarity of feelings. In contrast to older women, oxytocin relative to placebo increased attention to feelings in older men. Oxytocin relative to placebo enhanced meta-mood in young female participants but reduced it in older female participants. This pattern of findings supports an age- and sex-differential modulatory function of the neuropeptide oxytocin on meta-mood, possibly associated with neurobiological differences with age and sex.

No MeSH data available.