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The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task.

Di Ciano P, Pushparaj A, Kim A, Hatch J, Masood T, Ramzi A, Khaled MA, Boileau I, Winstanley CA, Le Foll B - PLoS ONE (2015)

Bottom Line: The present study therefore aimed to investigate the effects of selective antagonists and agonists of D2, D3 and D4 receptors in a rodent analogue of the Iowa gambling task used clinically.In this rat gambling task (rGT), animals are trained to associate different response holes with different magnitudes and probabilities of food pellet rewards and punishing time-out periods.Only the D4 drug had modest effects on latency measures suggesting that D4 may contribute in some ways to decision making under this task.

View Article: PubMed Central - PubMed

Affiliation: Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1.

ABSTRACT
Gambling is an addictive disorder with serious societal and personal costs. To-date, there are no approved pharmacological treatments for gambling disorder. Evidence suggests a role for dopamine in gambling disorder and thus may provide a therapeutic target. The present study therefore aimed to investigate the effects of selective antagonists and agonists of D2, D3 and D4 receptors in a rodent analogue of the Iowa gambling task used clinically. In this rat gambling task (rGT), animals are trained to associate different response holes with different magnitudes and probabilities of food pellet rewards and punishing time-out periods. As in the Iowa gambling task, the optimal strategy is to avoid the tempting high-risk high-reward options, and instead favor those linked to smaller per-trial rewards but also lower punishments, thereby maximizing the amount of reward earned over time. Administration of those selective ligands did not affect decision making under the rGT. Only the D4 drug had modest effects on latency measures suggesting that D4 may contribute in some ways to decision making under this task.

No MeSH data available.


Related in: MedlinePlus

Effect of administration of a D3 agonist on the rGT.A: Mean ± SEM percent choice on the advantageous choice (dark bars), omissions (grey bars) and premature responses (open bars). B: Mean ± SEM number of trials initiated. C: Mean ± SEM latency to make a choice (grey bars) and latency to collect the food pellets (open bars). D: Ratio ± SEM perseverative responses for punished trials (grey bars) and rewarded trials (open bars). No significant differences were found for any analyses (n = 17).
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pone.0136267.g004: Effect of administration of a D3 agonist on the rGT.A: Mean ± SEM percent choice on the advantageous choice (dark bars), omissions (grey bars) and premature responses (open bars). B: Mean ± SEM number of trials initiated. C: Mean ± SEM latency to make a choice (grey bars) and latency to collect the food pellets (open bars). D: Ratio ± SEM perseverative responses for punished trials (grey bars) and rewarded trials (open bars). No significant differences were found for any analyses (n = 17).

Mentions: A two-way Measure (advantageous, omissions, premature) X Dose (5 levels) ANOVA revealed only an effect of Measure (Fig 4; F(2,30) = 40.710, p<0.001, partial eta squared = .731), indicating that the percentage of each measure differed but not by dose (Fig 4A). No effect of Dose was revealed for the number of trials initiated (Fig 4B). Analysis of latencies (Fig 4C) with a two-way repeated-measures Measure (Choice latency, Collect latency) X Dose (4 levels) ANOVA revealed only an effect of Latency (F(1, 15) = 12.207, p<0.01; partial eta squared = .449). A two-way Measure (Punishment, Perseveration, Reward Perseveration) X Dose (4 levels) ANOVA revealed no effects (Fig 4D).


The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task.

Di Ciano P, Pushparaj A, Kim A, Hatch J, Masood T, Ramzi A, Khaled MA, Boileau I, Winstanley CA, Le Foll B - PLoS ONE (2015)

Effect of administration of a D3 agonist on the rGT.A: Mean ± SEM percent choice on the advantageous choice (dark bars), omissions (grey bars) and premature responses (open bars). B: Mean ± SEM number of trials initiated. C: Mean ± SEM latency to make a choice (grey bars) and latency to collect the food pellets (open bars). D: Ratio ± SEM perseverative responses for punished trials (grey bars) and rewarded trials (open bars). No significant differences were found for any analyses (n = 17).
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4564230&req=5

pone.0136267.g004: Effect of administration of a D3 agonist on the rGT.A: Mean ± SEM percent choice on the advantageous choice (dark bars), omissions (grey bars) and premature responses (open bars). B: Mean ± SEM number of trials initiated. C: Mean ± SEM latency to make a choice (grey bars) and latency to collect the food pellets (open bars). D: Ratio ± SEM perseverative responses for punished trials (grey bars) and rewarded trials (open bars). No significant differences were found for any analyses (n = 17).
Mentions: A two-way Measure (advantageous, omissions, premature) X Dose (5 levels) ANOVA revealed only an effect of Measure (Fig 4; F(2,30) = 40.710, p<0.001, partial eta squared = .731), indicating that the percentage of each measure differed but not by dose (Fig 4A). No effect of Dose was revealed for the number of trials initiated (Fig 4B). Analysis of latencies (Fig 4C) with a two-way repeated-measures Measure (Choice latency, Collect latency) X Dose (4 levels) ANOVA revealed only an effect of Latency (F(1, 15) = 12.207, p<0.01; partial eta squared = .449). A two-way Measure (Punishment, Perseveration, Reward Perseveration) X Dose (4 levels) ANOVA revealed no effects (Fig 4D).

Bottom Line: The present study therefore aimed to investigate the effects of selective antagonists and agonists of D2, D3 and D4 receptors in a rodent analogue of the Iowa gambling task used clinically.In this rat gambling task (rGT), animals are trained to associate different response holes with different magnitudes and probabilities of food pellet rewards and punishing time-out periods.Only the D4 drug had modest effects on latency measures suggesting that D4 may contribute in some ways to decision making under this task.

View Article: PubMed Central - PubMed

Affiliation: Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1.

ABSTRACT
Gambling is an addictive disorder with serious societal and personal costs. To-date, there are no approved pharmacological treatments for gambling disorder. Evidence suggests a role for dopamine in gambling disorder and thus may provide a therapeutic target. The present study therefore aimed to investigate the effects of selective antagonists and agonists of D2, D3 and D4 receptors in a rodent analogue of the Iowa gambling task used clinically. In this rat gambling task (rGT), animals are trained to associate different response holes with different magnitudes and probabilities of food pellet rewards and punishing time-out periods. As in the Iowa gambling task, the optimal strategy is to avoid the tempting high-risk high-reward options, and instead favor those linked to smaller per-trial rewards but also lower punishments, thereby maximizing the amount of reward earned over time. Administration of those selective ligands did not affect decision making under the rGT. Only the D4 drug had modest effects on latency measures suggesting that D4 may contribute in some ways to decision making under this task.

No MeSH data available.


Related in: MedlinePlus