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Lung protective ventilation in patients undergoing major surgery: a systematic review incorporating a Bayesian approach.

Zhang Z, Hu X, Zhang X, Zhu X, Chen L, Zhu L, Hu C, Du B, China Critical Care Clinical Trials Group (CCCCT - BMJ Open (2015)

Bottom Line: PV had protective effect against the development of ALI as compared with the control group, with an OR of 0.41 (95% CI 0.19 to 0.87).Other adverse outcomes such as new onset arrhythmia were significantly reduced with the use of PV (OR 0.47, 95% CI 0.48 to 0.93).However, there is insufficient evidence that such a beneficial effect can be translated to more clinically relevant outcomes such as mortality or duration of MV.

View Article: PubMed Central - PubMed

Affiliation: Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang, People's Republic of China.

No MeSH data available.


Related in: MedlinePlus

Risk of bias for included component studies assessed from items of blindness, sequence generation, allocation concealment, sample size calculation, clear definition of eligibility criteria, comparability of baseline characteristics, intention to treat analysis and use of point estimate and variability. The x axis is scaled to represent the proportion of component studies with either item of ‘yes’, ‘no’ or ‘unclear’.
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BMJOPEN2014007473F2: Risk of bias for included component studies assessed from items of blindness, sequence generation, allocation concealment, sample size calculation, clear definition of eligibility criteria, comparability of baseline characteristics, intention to treat analysis and use of point estimate and variability. The x axis is scaled to represent the proportion of component studies with either item of ‘yes’, ‘no’ or ‘unclear’.

Mentions: Tables 1 and 2 show some important characteristics of individual component studies. In most studies, the mean ages ranged between 50 and 70 years. However, the mean age of Cai K's study was around 20 years. The percentage of male patients varied significantly across component studies, ranging from 41% to 83%. Tidal volumes in the PV group were significantly lower than in the control group, and PEEP was significantly higher in the PV group than in the control group. Risk of bias was assessed from 10 items. As shown in figure 2, all studies reported point estimate and variability for study end points. Baseline characteristics were comparable in most studies. However, the blindness to both outcome assessor and caregiver was not performed or unknown in most included studies.


Lung protective ventilation in patients undergoing major surgery: a systematic review incorporating a Bayesian approach.

Zhang Z, Hu X, Zhang X, Zhu X, Chen L, Zhu L, Hu C, Du B, China Critical Care Clinical Trials Group (CCCCT - BMJ Open (2015)

Risk of bias for included component studies assessed from items of blindness, sequence generation, allocation concealment, sample size calculation, clear definition of eligibility criteria, comparability of baseline characteristics, intention to treat analysis and use of point estimate and variability. The x axis is scaled to represent the proportion of component studies with either item of ‘yes’, ‘no’ or ‘unclear’.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563268&req=5

BMJOPEN2014007473F2: Risk of bias for included component studies assessed from items of blindness, sequence generation, allocation concealment, sample size calculation, clear definition of eligibility criteria, comparability of baseline characteristics, intention to treat analysis and use of point estimate and variability. The x axis is scaled to represent the proportion of component studies with either item of ‘yes’, ‘no’ or ‘unclear’.
Mentions: Tables 1 and 2 show some important characteristics of individual component studies. In most studies, the mean ages ranged between 50 and 70 years. However, the mean age of Cai K's study was around 20 years. The percentage of male patients varied significantly across component studies, ranging from 41% to 83%. Tidal volumes in the PV group were significantly lower than in the control group, and PEEP was significantly higher in the PV group than in the control group. Risk of bias was assessed from 10 items. As shown in figure 2, all studies reported point estimate and variability for study end points. Baseline characteristics were comparable in most studies. However, the blindness to both outcome assessor and caregiver was not performed or unknown in most included studies.

Bottom Line: PV had protective effect against the development of ALI as compared with the control group, with an OR of 0.41 (95% CI 0.19 to 0.87).Other adverse outcomes such as new onset arrhythmia were significantly reduced with the use of PV (OR 0.47, 95% CI 0.48 to 0.93).However, there is insufficient evidence that such a beneficial effect can be translated to more clinically relevant outcomes such as mortality or duration of MV.

View Article: PubMed Central - PubMed

Affiliation: Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang, People's Republic of China.

No MeSH data available.


Related in: MedlinePlus