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What is the influence of randomisation sequence generation and allocation concealment on treatment effects of physical therapy trials? A meta-epidemiological study.

Armijo-Olivo S, Saltaji H, da Costa BR, Fuentes J, Ha C, Cummings GG - BMJ Open (2015)

Bottom Line: Data extraction including assessments of random sequence generation and allocation concealment was conducted independently by two reviewers.When pooling our results with those of Nuesch et al, we obtained a pooled statistically significant value (ES=0.14; 95% CI 0.02 to 0.26).Our results suggest that when evaluating risk of bias of primary RCTs in PT area, systematic reviewers and clinicians implementing research into practice should pay attention to these biases since they could exaggerate treatment effects.

View Article: PubMed Central - PubMed

Affiliation: CLEAR Outcomes (Connecting Leadership, Education and Research) Research Program, University of Alberta, Edmonton Clinic Health Academy (ECHA), Edmonton, Alberta, Canada Faculty of Rehabilitation Medicine, Department of Physical Therapy, University of Alberta, Edmonton, Alberta, Canada Faculty of Rehabilitation Medicine, Rehabilitation Research Center, University of Alberta, Edmonton, Alberta, Canada.

No MeSH data available.


Pooled data of the effect of concealment of allocation on treatment effect estimates using continuous outcomes.
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BMJOPEN2015008562F6: Pooled data of the effect of concealment of allocation on treatment effect estimates using continuous outcomes.

Mentions: When pooling our results with those of Nuesch et al,1 who performed a meta-epidemiological study with continuous outcomes as well, we obtained a pooled statistically significant value (ES=0.14; 95% CI 0.02 to 0.26), meaning that trials with inappropriate concealment of allocation had more beneficial effect than trials with appropriate concealment of allocation (figure 6).


What is the influence of randomisation sequence generation and allocation concealment on treatment effects of physical therapy trials? A meta-epidemiological study.

Armijo-Olivo S, Saltaji H, da Costa BR, Fuentes J, Ha C, Cummings GG - BMJ Open (2015)

Pooled data of the effect of concealment of allocation on treatment effect estimates using continuous outcomes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563231&req=5

BMJOPEN2015008562F6: Pooled data of the effect of concealment of allocation on treatment effect estimates using continuous outcomes.
Mentions: When pooling our results with those of Nuesch et al,1 who performed a meta-epidemiological study with continuous outcomes as well, we obtained a pooled statistically significant value (ES=0.14; 95% CI 0.02 to 0.26), meaning that trials with inappropriate concealment of allocation had more beneficial effect than trials with appropriate concealment of allocation (figure 6).

Bottom Line: Data extraction including assessments of random sequence generation and allocation concealment was conducted independently by two reviewers.When pooling our results with those of Nuesch et al, we obtained a pooled statistically significant value (ES=0.14; 95% CI 0.02 to 0.26).Our results suggest that when evaluating risk of bias of primary RCTs in PT area, systematic reviewers and clinicians implementing research into practice should pay attention to these biases since they could exaggerate treatment effects.

View Article: PubMed Central - PubMed

Affiliation: CLEAR Outcomes (Connecting Leadership, Education and Research) Research Program, University of Alberta, Edmonton Clinic Health Academy (ECHA), Edmonton, Alberta, Canada Faculty of Rehabilitation Medicine, Department of Physical Therapy, University of Alberta, Edmonton, Alberta, Canada Faculty of Rehabilitation Medicine, Rehabilitation Research Center, University of Alberta, Edmonton, Alberta, Canada.

No MeSH data available.