Limits...
Dermal and Ophthalmic Findings in Pseudohypoaldosteronism.

Korkut S, Gökalp E, Özdemir A, Kurtoğlu S, Demirtaş Ş, Gül Ü, Baştuğ O - J Clin Res Pediatr Endocrinol (2015)

Bottom Line: Dermal findings in the form of miliaria rubra can also develop in these patients.With the loss of salt, abnormal accumulation of sebum in the eye due to a defect in the sodium channels can also occur.In this paper, a case of PHA in a newborn showing typical dermatological and ophthalmological findings is presented.

View Article: PubMed Central - PubMed

Affiliation: Erciyes University Faculty of Medicine, Department of Neonatology, Kayseri, Turkey Phone:+90 352 207 66 66 E-mail: sabriyeyaman@hotmail.com.

ABSTRACT
Pseudohypoaldosteronism (PHA) is defined as a state of resistance to aldosterone, a hormone crucial for electrolyte equilibrium. The genetically transmitted type of PHA is primary hypoaldosteronism. Secondary hypoaldosteronism develops as a result of hydronephrosis or hydroureter. PHA patients suffer from severe hyponatremia and a severe clinical condition due to severe loss of salt can be encountered in the neonatal period. Dermal findings in the form of miliaria rubra can also develop in these patients. With the loss of salt, abnormal accumulation of sebum in the eye due to a defect in the sodium channels can also occur. In this paper, a case of PHA in a newborn showing typical dermatological and ophthalmological findings is presented.

No MeSH data available.


Related in: MedlinePlus

Presence of a white opaque discharge with an appearance of a row of teeth at the bottom of the eyelashes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4563190&req=5

f3: Presence of a white opaque discharge with an appearance of a row of teeth at the bottom of the eyelashes.

Mentions: At admission, the infant’s body weight was 2740 g (10th-25th percentiles). Her length was 52 cm (50th-75th percentiles) and her head circumference was 35 cm (50th percentile). The general condition of the patient appeared to be good and she was active. Miliaria rubra were noted on her face, her arms and her chest (Figure 1). Presence of salt crystals could be detected at the base of the follicles of the face (Figure 2). There was a white opaque discharge at the bottom of the eyelashes and macerations around the eye were noted (Figure 3). The remaining systemic examination findings were normal. Laboratory assessment revealed a hemoglobin level of 19.5 g/dL, WBC 18870/mm3, a thrombocyte count of 412000/mm3, a hematocrit level of 59%. C-reactive protein level was 3.44 mg/L, blood glucose 82 mg/dL, blood urea nitrogen 22 mg/dL, creatinine 0.4 mg/dL, sodium 129 mEq/L, potassium 6.5 mEq/L, calcium 10.8 gm/dL and phosphorus was 6.4 gm/dL.


Dermal and Ophthalmic Findings in Pseudohypoaldosteronism.

Korkut S, Gökalp E, Özdemir A, Kurtoğlu S, Demirtaş Ş, Gül Ü, Baştuğ O - J Clin Res Pediatr Endocrinol (2015)

Presence of a white opaque discharge with an appearance of a row of teeth at the bottom of the eyelashes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563190&req=5

f3: Presence of a white opaque discharge with an appearance of a row of teeth at the bottom of the eyelashes.
Mentions: At admission, the infant’s body weight was 2740 g (10th-25th percentiles). Her length was 52 cm (50th-75th percentiles) and her head circumference was 35 cm (50th percentile). The general condition of the patient appeared to be good and she was active. Miliaria rubra were noted on her face, her arms and her chest (Figure 1). Presence of salt crystals could be detected at the base of the follicles of the face (Figure 2). There was a white opaque discharge at the bottom of the eyelashes and macerations around the eye were noted (Figure 3). The remaining systemic examination findings were normal. Laboratory assessment revealed a hemoglobin level of 19.5 g/dL, WBC 18870/mm3, a thrombocyte count of 412000/mm3, a hematocrit level of 59%. C-reactive protein level was 3.44 mg/L, blood glucose 82 mg/dL, blood urea nitrogen 22 mg/dL, creatinine 0.4 mg/dL, sodium 129 mEq/L, potassium 6.5 mEq/L, calcium 10.8 gm/dL and phosphorus was 6.4 gm/dL.

Bottom Line: Dermal findings in the form of miliaria rubra can also develop in these patients.With the loss of salt, abnormal accumulation of sebum in the eye due to a defect in the sodium channels can also occur.In this paper, a case of PHA in a newborn showing typical dermatological and ophthalmological findings is presented.

View Article: PubMed Central - PubMed

Affiliation: Erciyes University Faculty of Medicine, Department of Neonatology, Kayseri, Turkey Phone:+90 352 207 66 66 E-mail: sabriyeyaman@hotmail.com.

ABSTRACT
Pseudohypoaldosteronism (PHA) is defined as a state of resistance to aldosterone, a hormone crucial for electrolyte equilibrium. The genetically transmitted type of PHA is primary hypoaldosteronism. Secondary hypoaldosteronism develops as a result of hydronephrosis or hydroureter. PHA patients suffer from severe hyponatremia and a severe clinical condition due to severe loss of salt can be encountered in the neonatal period. Dermal findings in the form of miliaria rubra can also develop in these patients. With the loss of salt, abnormal accumulation of sebum in the eye due to a defect in the sodium channels can also occur. In this paper, a case of PHA in a newborn showing typical dermatological and ophthalmological findings is presented.

No MeSH data available.


Related in: MedlinePlus