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Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?

Evliyaoğlu O, Acar M, Özcabı B, Erginöz E, Bucak F, Ercan O, Kucur M - J Clin Res Pediatr Endocrinol (2015)

Bottom Line: Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001).Vitamin D deficiency is associated with HT in children and adolescents.Levels lower than 20 ng/mL seem to be critical.

View Article: PubMed Central - PubMed

Affiliation: İstanbul University Cerrahpaşa Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey Phone: +90 533 633 15 64 E-mail: olcayevliyaoglu@hotmail.com.

ABSTRACT

Objective: Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients.

Methods: This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects.

Results: The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3).

Conclusion: Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.

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Related in: MedlinePlus

There was a positive correlation between serum 25-hydroxyvitamin D3 levels and total thyroxine in the patients with autoimmune thyroiditis (r=0.37, p<0.05).
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f3: There was a positive correlation between serum 25-hydroxyvitamin D3 levels and total thyroxine in the patients with autoimmune thyroiditis (r=0.37, p<0.05).

Mentions: In the total group of patients, serum 25(OH)D3 level was positively correlated with serum total T4 (r=0.37; p=0.018) (Figure 3). There was no correlation between 25(OH)D3 levels and T3, TSH or thyroid autoantibodies.


Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?

Evliyaoğlu O, Acar M, Özcabı B, Erginöz E, Bucak F, Ercan O, Kucur M - J Clin Res Pediatr Endocrinol (2015)

There was a positive correlation between serum 25-hydroxyvitamin D3 levels and total thyroxine in the patients with autoimmune thyroiditis (r=0.37, p<0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563184&req=5

f3: There was a positive correlation between serum 25-hydroxyvitamin D3 levels and total thyroxine in the patients with autoimmune thyroiditis (r=0.37, p<0.05).
Mentions: In the total group of patients, serum 25(OH)D3 level was positively correlated with serum total T4 (r=0.37; p=0.018) (Figure 3). There was no correlation between 25(OH)D3 levels and T3, TSH or thyroid autoantibodies.

Bottom Line: Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001).Vitamin D deficiency is associated with HT in children and adolescents.Levels lower than 20 ng/mL seem to be critical.

View Article: PubMed Central - PubMed

Affiliation: İstanbul University Cerrahpaşa Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey Phone: +90 533 633 15 64 E-mail: olcayevliyaoglu@hotmail.com.

ABSTRACT

Objective: Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients.

Methods: This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects.

Results: The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3).

Conclusion: Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.

Show MeSH
Related in: MedlinePlus