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Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?

Evliyaoğlu O, Acar M, Özcabı B, Erginöz E, Bucak F, Ercan O, Kucur M - J Clin Res Pediatr Endocrinol (2015)

Bottom Line: Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001).Vitamin D deficiency is associated with HT in children and adolescents.Levels lower than 20 ng/mL seem to be critical.

View Article: PubMed Central - PubMed

Affiliation: İstanbul University Cerrahpaşa Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey Phone: +90 533 633 15 64 E-mail: olcayevliyaoglu@hotmail.com.

ABSTRACT

Objective: Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients.

Methods: This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects.

Results: The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3).

Conclusion: Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.

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Related in: MedlinePlus

Prevalence of 25-hydroxyvitamin D3 [25(OH)D3] deficiency, insufficiency and sufficiency in Hashimoto thyroiditis patients and in the control group. Prevalence of 25(OH)D3 deficiency in Hashimoto thyroiditis patients was significantly higher than that of the control group (*p=0.025).
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f2: Prevalence of 25-hydroxyvitamin D3 [25(OH)D3] deficiency, insufficiency and sufficiency in Hashimoto thyroiditis patients and in the control group. Prevalence of 25(OH)D3 deficiency in Hashimoto thyroiditis patients was significantly higher than that of the control group (*p=0.025).

Mentions: Demographic characteristics of the patients with HT and the control group are presented in Table 1. Median 25(OH)D3 level was 16.67 ng/mL (range: 1.5-67.30 ng/mL) for patients with HT and 20.99 ng/mL (range: 5.7-59.20 ng/mL) for the controls (Figure 1). Mean serum 25(OH)D3 level was 16.67±11.65 ng/mL and 20.99±9.86 ng/mL in patients with HT and in the controls, respectively. Mean 25(OH)D3 level was significantly lower in HT patients as compared with the healthy control group (p=0.001). To further evaluate the relationship between 25(OH)D3 levels and HT, the odd ratio between 25(OH)D3 levels and HT was calculated by one variable logistic regression. HT was observed to be more frequent in the individuals with a 25(OH)D3 level <20 ng/mL (OR: 2.28, CI: 1.21-4.3). In patients with HT, the prevalence rates of 25(OH)D3 deficiency, insufficiency and sufficiency were 71% (n=64), 17.7% (n=16) and 11.1% (n=10), respectively. In the control group, these prevalence figures were 51.9% (n=41), 35.4% (n=28) and 12.6% (n=10) in the same order. In HT patients, the incidence of 25(OH)D3 deficiency was significantly higher than that of the control group (p=0.025) (Figure 2).


Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?

Evliyaoğlu O, Acar M, Özcabı B, Erginöz E, Bucak F, Ercan O, Kucur M - J Clin Res Pediatr Endocrinol (2015)

Prevalence of 25-hydroxyvitamin D3 [25(OH)D3] deficiency, insufficiency and sufficiency in Hashimoto thyroiditis patients and in the control group. Prevalence of 25(OH)D3 deficiency in Hashimoto thyroiditis patients was significantly higher than that of the control group (*p=0.025).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563184&req=5

f2: Prevalence of 25-hydroxyvitamin D3 [25(OH)D3] deficiency, insufficiency and sufficiency in Hashimoto thyroiditis patients and in the control group. Prevalence of 25(OH)D3 deficiency in Hashimoto thyroiditis patients was significantly higher than that of the control group (*p=0.025).
Mentions: Demographic characteristics of the patients with HT and the control group are presented in Table 1. Median 25(OH)D3 level was 16.67 ng/mL (range: 1.5-67.30 ng/mL) for patients with HT and 20.99 ng/mL (range: 5.7-59.20 ng/mL) for the controls (Figure 1). Mean serum 25(OH)D3 level was 16.67±11.65 ng/mL and 20.99±9.86 ng/mL in patients with HT and in the controls, respectively. Mean 25(OH)D3 level was significantly lower in HT patients as compared with the healthy control group (p=0.001). To further evaluate the relationship between 25(OH)D3 levels and HT, the odd ratio between 25(OH)D3 levels and HT was calculated by one variable logistic regression. HT was observed to be more frequent in the individuals with a 25(OH)D3 level <20 ng/mL (OR: 2.28, CI: 1.21-4.3). In patients with HT, the prevalence rates of 25(OH)D3 deficiency, insufficiency and sufficiency were 71% (n=64), 17.7% (n=16) and 11.1% (n=10), respectively. In the control group, these prevalence figures were 51.9% (n=41), 35.4% (n=28) and 12.6% (n=10) in the same order. In HT patients, the incidence of 25(OH)D3 deficiency was significantly higher than that of the control group (p=0.025) (Figure 2).

Bottom Line: Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001).Vitamin D deficiency is associated with HT in children and adolescents.Levels lower than 20 ng/mL seem to be critical.

View Article: PubMed Central - PubMed

Affiliation: İstanbul University Cerrahpaşa Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey Phone: +90 533 633 15 64 E-mail: olcayevliyaoglu@hotmail.com.

ABSTRACT

Objective: Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients.

Methods: This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects.

Results: The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3).

Conclusion: Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.

Show MeSH
Related in: MedlinePlus