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Clinical Significance of Lymphoscintigraphy Findings in the Evaluation of Lower Extremity Lymphedema.

Karaçavuş S, Yılmaz YK, Ekim H - Mol Imaging Radionucl Ther (2015)

Bottom Line: The rate of popliteal node visualization was higher in patients with dermal backflow as compared to those without dermal backflow (p<0.001).The duration of lymphedema was also longer in patients with dermal backflow and popliteal nodes (p<0.004).Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Bozok University Faculty of Medicine, Department of Nuclear Medicine, Yozgat, Turkey Phone: +90 505 267 82 09 E-mail: seyhan.karacavus@bozok.edu.tr.

ABSTRACT

Objective: The purpose of this study was to investigate the clinical significance of lymphoscintigraphy imaging in the evaluation of lower extremity lymphedema.

Methods: Technetium-99m-labeled nanocolloid was injected subcutaneously in the first web spaces of both feet of 123 patients (M/F: 43/80, mean age 57.5±13.1 years, range 16-78 years) who had clinical evidence of lower extremity swelling with suspicion of lymphedema, and were referred for routine lymphoscintigraphy. Lymphoscintigraphy scan was started as dynamic viewing followed by static whole body imaging at 10 minute, 1 hour and 4 hours after injection.

Results: Eighty-seven patients had lymphedema. Patients who had lymphedema were divided into two groups according to their scintigraphy findings: Group I included 58 patients without uptake in the popliteal nodes, and group II included 29 patients with positive popliteal nodes. The rate of popliteal node visualization was higher in patients with dermal backflow as compared to those without dermal backflow (p<0.001). The duration of lymphedema was also longer in patients with dermal backflow and popliteal nodes (p<0.004).

Conclusion: Lymphoscintigraphy is a reliable, easily applied and well-tolerated objective method to diagnose lower extremity lymphedema. Uptake by popliteal lymph nodes and the presence of dermal backflow on lymphoscintigraphy, which is performed for evaluation of the lower limb lymphedema, were important signs indicating longer disease duration and higher severity of lymphatic dysfunction.

No MeSH data available.


Related in: MedlinePlus

Lymphoscintigraphic findings of a normal subject. a) dynamic images b) 10th minute static whole body imaging c) 1st hour static imaging d) 1st hour static imaging
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f1: Lymphoscintigraphic findings of a normal subject. a) dynamic images b) 10th minute static whole body imaging c) 1st hour static imaging d) 1st hour static imaging

Mentions: The patient was placed in supine position under a large field gamma camera (Philips Medical Systems Brightview Gamma Diagnost, Best, Holland), which included a low-energy general purpose collimator set at 140 KeV with 20% window, zoom 1.0 with 256×256 matrix size. The lymphoscintigraphy studies were performed by subcutaneous injection of 20 MBq (0.5 mCi) of technetium-99m-labeled nanocolloid (Senti-Scint; MEDI-Radiopharma, Budapest, Hungary) in a volume of 0.1 mL, using 26-gauge needle into the webbed spaces of both feet. The injection sites were massaged for 30 sec. following injection. Immediately after the injection, dynamic images were obtained for 2 min and static whole body imaging were recorded at 10th min, 1st, 4th and 24th hours when required (Figure 1). Patients were asked to take a short walk between the early and delayed scans without any strong exercise.


Clinical Significance of Lymphoscintigraphy Findings in the Evaluation of Lower Extremity Lymphedema.

Karaçavuş S, Yılmaz YK, Ekim H - Mol Imaging Radionucl Ther (2015)

Lymphoscintigraphic findings of a normal subject. a) dynamic images b) 10th minute static whole body imaging c) 1st hour static imaging d) 1st hour static imaging
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563174&req=5

f1: Lymphoscintigraphic findings of a normal subject. a) dynamic images b) 10th minute static whole body imaging c) 1st hour static imaging d) 1st hour static imaging
Mentions: The patient was placed in supine position under a large field gamma camera (Philips Medical Systems Brightview Gamma Diagnost, Best, Holland), which included a low-energy general purpose collimator set at 140 KeV with 20% window, zoom 1.0 with 256×256 matrix size. The lymphoscintigraphy studies were performed by subcutaneous injection of 20 MBq (0.5 mCi) of technetium-99m-labeled nanocolloid (Senti-Scint; MEDI-Radiopharma, Budapest, Hungary) in a volume of 0.1 mL, using 26-gauge needle into the webbed spaces of both feet. The injection sites were massaged for 30 sec. following injection. Immediately after the injection, dynamic images were obtained for 2 min and static whole body imaging were recorded at 10th min, 1st, 4th and 24th hours when required (Figure 1). Patients were asked to take a short walk between the early and delayed scans without any strong exercise.

Bottom Line: The rate of popliteal node visualization was higher in patients with dermal backflow as compared to those without dermal backflow (p<0.001).The duration of lymphedema was also longer in patients with dermal backflow and popliteal nodes (p<0.004).Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Bozok University Faculty of Medicine, Department of Nuclear Medicine, Yozgat, Turkey Phone: +90 505 267 82 09 E-mail: seyhan.karacavus@bozok.edu.tr.

ABSTRACT

Objective: The purpose of this study was to investigate the clinical significance of lymphoscintigraphy imaging in the evaluation of lower extremity lymphedema.

Methods: Technetium-99m-labeled nanocolloid was injected subcutaneously in the first web spaces of both feet of 123 patients (M/F: 43/80, mean age 57.5±13.1 years, range 16-78 years) who had clinical evidence of lower extremity swelling with suspicion of lymphedema, and were referred for routine lymphoscintigraphy. Lymphoscintigraphy scan was started as dynamic viewing followed by static whole body imaging at 10 minute, 1 hour and 4 hours after injection.

Results: Eighty-seven patients had lymphedema. Patients who had lymphedema were divided into two groups according to their scintigraphy findings: Group I included 58 patients without uptake in the popliteal nodes, and group II included 29 patients with positive popliteal nodes. The rate of popliteal node visualization was higher in patients with dermal backflow as compared to those without dermal backflow (p<0.001). The duration of lymphedema was also longer in patients with dermal backflow and popliteal nodes (p<0.004).

Conclusion: Lymphoscintigraphy is a reliable, easily applied and well-tolerated objective method to diagnose lower extremity lymphedema. Uptake by popliteal lymph nodes and the presence of dermal backflow on lymphoscintigraphy, which is performed for evaluation of the lower limb lymphedema, were important signs indicating longer disease duration and higher severity of lymphatic dysfunction.

No MeSH data available.


Related in: MedlinePlus