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Proliferative and Glycolytic Assessment of the Whole-Body Bone Marrow Compartment.

Goryawala M, Adjoua M, Güleç S - Mol Imaging Radionucl Ther (2015)

Bottom Line: RBV obtained using 18F-FLT in males were found to have high correlation with measured weight (R2=0.61) and BMI (R2=0.70).Results also show that spinal activity SUV threshold for red BM segmentation is significantly different between 18F-FLT PET and 18F-FDG PET (p<0.05).Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Seza Güleç MD, Florida International University Herbert Wertheim College, Department of Surgery, Miami, USA Phone: +17866930821 E-mail: sgulec@fiu.edu.

ABSTRACT

Objective: Quantitative assessment of active bone marrow (BM) in vivo is yet to be well-defined. This study aims to compare total body BM volume estimations obtained from use of both18F-FLT PET/CT and 18F-FDG PET/CT in order to consolidate higher cellular proliferation rates with imaging the highly active red BM in pancreatic cancer.

Methods: This phase I pilot study includes seven patients with pancreatic cancers who underwent both 18F-FLT and 18F-FDG imaging each acquired within a week's duration. A CT-based classifier is used for segmenting bone into cortical and trabecular regions. The total BM volume is determined through statistical thresholding on PET activity found within the trabecular bone.

Results: Results showed that 18F-FLT measures of red BM volume (RBV) were higher than those obtained from 18F-FDG (∆=89.21 ml). RBV obtained using 18F-FLT in males were found to have high correlation with measured weight (R2=0.61) and BMI (R2=0.70). The red BM fraction obtained from 18F-FLT was significantly different between males and females, with females showing much higher red bone matter within the trabecular bone (p<0.05). In contrast to 18F-FLT, 18F-FDG BM measurements showed that RBV was significantly different between males and females (p<0.05). Results also show that spinal activity SUV threshold for red BM segmentation is significantly different between 18F-FLT PET and 18F-FDG PET (p<0.05).

Conclusion: By combining 18F-FLT-PET and 18F-FDG-PET, this study provides useful insights for in vivo BM estimation through its proliferative and glycolytic activities.

No MeSH data available.


Related in: MedlinePlus

Influence of (A) Measured Body Weight, and (B) Body Mass Index (BMI) on Red BM Volume (RBV) obtained from 18F-FLT imaging in all subjects, whereas (C) and (D) show the influence of measured body weight and BMI in only males, respectively. The RBVs showed better correlation to physical measurements when female subjects were excluded
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f3: Influence of (A) Measured Body Weight, and (B) Body Mass Index (BMI) on Red BM Volume (RBV) obtained from 18F-FLT imaging in all subjects, whereas (C) and (D) show the influence of measured body weight and BMI in only males, respectively. The RBVs showed better correlation to physical measurements when female subjects were excluded

Mentions: In addition, as seen in Figure 5, red BM volumes were not very well correlated to the mean spinal SUVs for 18F-FLT (R2=0.13; Figure 5A), but were comparatively better correlated in the case of 18F-FDG (R2=0.71; Figure 5C). Also, the yellow BM volumes were not very well correlated with the mean SUVs of the rest of the body for both FLT- and FDG-based estimations (Figure 5B and 5D).


Proliferative and Glycolytic Assessment of the Whole-Body Bone Marrow Compartment.

Goryawala M, Adjoua M, Güleç S - Mol Imaging Radionucl Ther (2015)

Influence of (A) Measured Body Weight, and (B) Body Mass Index (BMI) on Red BM Volume (RBV) obtained from 18F-FLT imaging in all subjects, whereas (C) and (D) show the influence of measured body weight and BMI in only males, respectively. The RBVs showed better correlation to physical measurements when female subjects were excluded
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563173&req=5

f3: Influence of (A) Measured Body Weight, and (B) Body Mass Index (BMI) on Red BM Volume (RBV) obtained from 18F-FLT imaging in all subjects, whereas (C) and (D) show the influence of measured body weight and BMI in only males, respectively. The RBVs showed better correlation to physical measurements when female subjects were excluded
Mentions: In addition, as seen in Figure 5, red BM volumes were not very well correlated to the mean spinal SUVs for 18F-FLT (R2=0.13; Figure 5A), but were comparatively better correlated in the case of 18F-FDG (R2=0.71; Figure 5C). Also, the yellow BM volumes were not very well correlated with the mean SUVs of the rest of the body for both FLT- and FDG-based estimations (Figure 5B and 5D).

Bottom Line: RBV obtained using 18F-FLT in males were found to have high correlation with measured weight (R2=0.61) and BMI (R2=0.70).Results also show that spinal activity SUV threshold for red BM segmentation is significantly different between 18F-FLT PET and 18F-FDG PET (p<0.05).Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Seza Güleç MD, Florida International University Herbert Wertheim College, Department of Surgery, Miami, USA Phone: +17866930821 E-mail: sgulec@fiu.edu.

ABSTRACT

Objective: Quantitative assessment of active bone marrow (BM) in vivo is yet to be well-defined. This study aims to compare total body BM volume estimations obtained from use of both18F-FLT PET/CT and 18F-FDG PET/CT in order to consolidate higher cellular proliferation rates with imaging the highly active red BM in pancreatic cancer.

Methods: This phase I pilot study includes seven patients with pancreatic cancers who underwent both 18F-FLT and 18F-FDG imaging each acquired within a week's duration. A CT-based classifier is used for segmenting bone into cortical and trabecular regions. The total BM volume is determined through statistical thresholding on PET activity found within the trabecular bone.

Results: Results showed that 18F-FLT measures of red BM volume (RBV) were higher than those obtained from 18F-FDG (∆=89.21 ml). RBV obtained using 18F-FLT in males were found to have high correlation with measured weight (R2=0.61) and BMI (R2=0.70). The red BM fraction obtained from 18F-FLT was significantly different between males and females, with females showing much higher red bone matter within the trabecular bone (p<0.05). In contrast to 18F-FLT, 18F-FDG BM measurements showed that RBV was significantly different between males and females (p<0.05). Results also show that spinal activity SUV threshold for red BM segmentation is significantly different between 18F-FLT PET and 18F-FDG PET (p<0.05).

Conclusion: By combining 18F-FLT-PET and 18F-FDG-PET, this study provides useful insights for in vivo BM estimation through its proliferative and glycolytic activities.

No MeSH data available.


Related in: MedlinePlus