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Proliferative and Glycolytic Assessment of the Whole-Body Bone Marrow Compartment.

Goryawala M, Adjoua M, Güleç S - Mol Imaging Radionucl Ther (2015)

Bottom Line: RBV obtained using 18F-FLT in males were found to have high correlation with measured weight (R2=0.61) and BMI (R2=0.70).Results also show that spinal activity SUV threshold for red BM segmentation is significantly different between 18F-FLT PET and 18F-FDG PET (p<0.05).Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Seza Güleç MD, Florida International University Herbert Wertheim College, Department of Surgery, Miami, USA Phone: +17866930821 E-mail: sgulec@fiu.edu.

ABSTRACT

Objective: Quantitative assessment of active bone marrow (BM) in vivo is yet to be well-defined. This study aims to compare total body BM volume estimations obtained from use of both18F-FLT PET/CT and 18F-FDG PET/CT in order to consolidate higher cellular proliferation rates with imaging the highly active red BM in pancreatic cancer.

Methods: This phase I pilot study includes seven patients with pancreatic cancers who underwent both 18F-FLT and 18F-FDG imaging each acquired within a week's duration. A CT-based classifier is used for segmenting bone into cortical and trabecular regions. The total BM volume is determined through statistical thresholding on PET activity found within the trabecular bone.

Results: Results showed that 18F-FLT measures of red BM volume (RBV) were higher than those obtained from 18F-FDG (∆=89.21 ml). RBV obtained using 18F-FLT in males were found to have high correlation with measured weight (R2=0.61) and BMI (R2=0.70). The red BM fraction obtained from 18F-FLT was significantly different between males and females, with females showing much higher red bone matter within the trabecular bone (p<0.05). In contrast to 18F-FLT, 18F-FDG BM measurements showed that RBV was significantly different between males and females (p<0.05). Results also show that spinal activity SUV threshold for red BM segmentation is significantly different between 18F-FLT PET and 18F-FDG PET (p<0.05).

Conclusion: By combining 18F-FLT-PET and 18F-FDG-PET, this study provides useful insights for in vivo BM estimation through its proliferative and glycolytic activities.

No MeSH data available.


Related in: MedlinePlus

Correlation between (A) Red BM Volume (RBV) to mean spinal SUV and (B) Yellow BM Volume (YBV) to mean rest of body SUV for 18F-FLT imaging. Parts (C) and (D) show the same result for 18F-FDG imaging. RBV are well-correlated for 18F-FDG but not for 18F-FLT imaging
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f5: Correlation between (A) Red BM Volume (RBV) to mean spinal SUV and (B) Yellow BM Volume (YBV) to mean rest of body SUV for 18F-FLT imaging. Parts (C) and (D) show the same result for 18F-FDG imaging. RBV are well-correlated for 18F-FDG but not for 18F-FLT imaging


Proliferative and Glycolytic Assessment of the Whole-Body Bone Marrow Compartment.

Goryawala M, Adjoua M, Güleç S - Mol Imaging Radionucl Ther (2015)

Correlation between (A) Red BM Volume (RBV) to mean spinal SUV and (B) Yellow BM Volume (YBV) to mean rest of body SUV for 18F-FLT imaging. Parts (C) and (D) show the same result for 18F-FDG imaging. RBV are well-correlated for 18F-FDG but not for 18F-FLT imaging
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563173&req=5

f5: Correlation between (A) Red BM Volume (RBV) to mean spinal SUV and (B) Yellow BM Volume (YBV) to mean rest of body SUV for 18F-FLT imaging. Parts (C) and (D) show the same result for 18F-FDG imaging. RBV are well-correlated for 18F-FDG but not for 18F-FLT imaging
Bottom Line: RBV obtained using 18F-FLT in males were found to have high correlation with measured weight (R2=0.61) and BMI (R2=0.70).Results also show that spinal activity SUV threshold for red BM segmentation is significantly different between 18F-FLT PET and 18F-FDG PET (p<0.05).Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Seza Güleç MD, Florida International University Herbert Wertheim College, Department of Surgery, Miami, USA Phone: +17866930821 E-mail: sgulec@fiu.edu.

ABSTRACT

Objective: Quantitative assessment of active bone marrow (BM) in vivo is yet to be well-defined. This study aims to compare total body BM volume estimations obtained from use of both18F-FLT PET/CT and 18F-FDG PET/CT in order to consolidate higher cellular proliferation rates with imaging the highly active red BM in pancreatic cancer.

Methods: This phase I pilot study includes seven patients with pancreatic cancers who underwent both 18F-FLT and 18F-FDG imaging each acquired within a week's duration. A CT-based classifier is used for segmenting bone into cortical and trabecular regions. The total BM volume is determined through statistical thresholding on PET activity found within the trabecular bone.

Results: Results showed that 18F-FLT measures of red BM volume (RBV) were higher than those obtained from 18F-FDG (∆=89.21 ml). RBV obtained using 18F-FLT in males were found to have high correlation with measured weight (R2=0.61) and BMI (R2=0.70). The red BM fraction obtained from 18F-FLT was significantly different between males and females, with females showing much higher red bone matter within the trabecular bone (p<0.05). In contrast to 18F-FLT, 18F-FDG BM measurements showed that RBV was significantly different between males and females (p<0.05). Results also show that spinal activity SUV threshold for red BM segmentation is significantly different between 18F-FLT PET and 18F-FDG PET (p<0.05).

Conclusion: By combining 18F-FLT-PET and 18F-FDG-PET, this study provides useful insights for in vivo BM estimation through its proliferative and glycolytic activities.

No MeSH data available.


Related in: MedlinePlus