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Nuclear Medicine in Thyroid Diseases in Pediatric and Adolescent Patients.

Volkan-Salancı B, Kıratlı PÖ - Mol Imaging Radionucl Ther (2015)

Bottom Line: Use of radioactivity in pediatric population is strictly controlled due to possible side effects such as secondary cancers; therefore, management of pediatric patients requires detailed literature knowledge.This article aims to overview current algorithms in the management of thyroid diseases and use of radionuclide therapy in pediatric and adolescent population.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Hacettepe University Faculty of Medicine, Department of Nuclear Medicine, Ankara, Turkey Phone: +90 312 305 13 36 E-mail: pkiratli@hacettepe.edu.tr.

ABSTRACT
Both benign and malignant diseases of the thyroid are rare in the pediatric and adolescent population, except congenital hypothyroidism. Nuclear medicine plays a major role, both in the diagnosis and therapy of thyroid pathologies. Use of radioactivity in pediatric population is strictly controlled due to possible side effects such as secondary cancers; therefore, management of pediatric patients requires detailed literature knowledge. This article aims to overview current algorithms in the management of thyroid diseases and use of radionuclide therapy in pediatric and adolescent population.

No MeSH data available.


Related in: MedlinePlus

19 year-old female had a 5 cm nodule in the left lobe of the thyroid that was suspicious for DTC on FNAB. She underwent bilateral total thyroidectomy with central lymph node dissection. Histopathologic diagnosis showed a 4 cm papillary thyroid cancer with follicular variant, without lymph node metastasis. Her thyroglobulin level three weeks after surgery was high (345 μIU/mL). The lung CT did not show lung metastasis (E). The patient received 100 mCi I-131 RAI therapy, and multipl lung and bone metastases were detected on wholebody I-131 imaging at the 7th post-therapy day (A-D)
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f3: 19 year-old female had a 5 cm nodule in the left lobe of the thyroid that was suspicious for DTC on FNAB. She underwent bilateral total thyroidectomy with central lymph node dissection. Histopathologic diagnosis showed a 4 cm papillary thyroid cancer with follicular variant, without lymph node metastasis. Her thyroglobulin level three weeks after surgery was high (345 μIU/mL). The lung CT did not show lung metastasis (E). The patient received 100 mCi I-131 RAI therapy, and multipl lung and bone metastases were detected on wholebody I-131 imaging at the 7th post-therapy day (A-D)

Mentions: Distant metastases, especially lung metastasis, are frequently seen in pediatric patients. Although it is not included as part of guidelines, increased postoperative thyroglobulin levels should warn the clinician for possible lung metastases, unless no residual tumor or metastatic lymph node is present after surgery. For this purpose, a screening lung CT without i.v. iodinated contrast can be carried out. However, it is not unusual to overlook miliary lung metastases on CT. Nearly half of the children with a negative CT show metastases on therapeutic I-131 wholebody imaging (Figure 3).


Nuclear Medicine in Thyroid Diseases in Pediatric and Adolescent Patients.

Volkan-Salancı B, Kıratlı PÖ - Mol Imaging Radionucl Ther (2015)

19 year-old female had a 5 cm nodule in the left lobe of the thyroid that was suspicious for DTC on FNAB. She underwent bilateral total thyroidectomy with central lymph node dissection. Histopathologic diagnosis showed a 4 cm papillary thyroid cancer with follicular variant, without lymph node metastasis. Her thyroglobulin level three weeks after surgery was high (345 μIU/mL). The lung CT did not show lung metastasis (E). The patient received 100 mCi I-131 RAI therapy, and multipl lung and bone metastases were detected on wholebody I-131 imaging at the 7th post-therapy day (A-D)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563170&req=5

f3: 19 year-old female had a 5 cm nodule in the left lobe of the thyroid that was suspicious for DTC on FNAB. She underwent bilateral total thyroidectomy with central lymph node dissection. Histopathologic diagnosis showed a 4 cm papillary thyroid cancer with follicular variant, without lymph node metastasis. Her thyroglobulin level three weeks after surgery was high (345 μIU/mL). The lung CT did not show lung metastasis (E). The patient received 100 mCi I-131 RAI therapy, and multipl lung and bone metastases were detected on wholebody I-131 imaging at the 7th post-therapy day (A-D)
Mentions: Distant metastases, especially lung metastasis, are frequently seen in pediatric patients. Although it is not included as part of guidelines, increased postoperative thyroglobulin levels should warn the clinician for possible lung metastases, unless no residual tumor or metastatic lymph node is present after surgery. For this purpose, a screening lung CT without i.v. iodinated contrast can be carried out. However, it is not unusual to overlook miliary lung metastases on CT. Nearly half of the children with a negative CT show metastases on therapeutic I-131 wholebody imaging (Figure 3).

Bottom Line: Use of radioactivity in pediatric population is strictly controlled due to possible side effects such as secondary cancers; therefore, management of pediatric patients requires detailed literature knowledge.This article aims to overview current algorithms in the management of thyroid diseases and use of radionuclide therapy in pediatric and adolescent population.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Hacettepe University Faculty of Medicine, Department of Nuclear Medicine, Ankara, Turkey Phone: +90 312 305 13 36 E-mail: pkiratli@hacettepe.edu.tr.

ABSTRACT
Both benign and malignant diseases of the thyroid are rare in the pediatric and adolescent population, except congenital hypothyroidism. Nuclear medicine plays a major role, both in the diagnosis and therapy of thyroid pathologies. Use of radioactivity in pediatric population is strictly controlled due to possible side effects such as secondary cancers; therefore, management of pediatric patients requires detailed literature knowledge. This article aims to overview current algorithms in the management of thyroid diseases and use of radionuclide therapy in pediatric and adolescent population.

No MeSH data available.


Related in: MedlinePlus