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Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study.

Nezu T, Hosomi N, Takahashi T, Anno K, Aoki S, Shimamoto A, Maruyama H, Hayashi T, Matsumoto M, Tahara H - EBioMedicine (2015)

Bottom Line: Shortened telomere G-tail length was associated with age and Framingham risk score (P = 0.018 and P = 0.012).On multivariate regression analysis, telomere G-tail length was independently associated with FMD values (P = 0.022) and the severity of ARWMCs (P = 0.033), whereas total telomere length was not associated with these indicators.Telomere G-tail length is associated with age and vascular risk factors, and might be superior to total telomere length as a marker of endothelial dysfunction and ARWMC severity.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.

ABSTRACT

Background: The telomeric 3'-overhang (G-tail) length is essential for the biological effects of telomere dysfunction in vitro, but the association of length with aging and cardiovascular risk is unclear in humans. We investigated the association between the telomere G-tail length of leukocytes and cardiovascular risk, age-related white matter changes (ARWMCs), and endothelial function.

Methods: Patients with a history of cerebrovascular disease and comorbidity were enrolled (n = 102; 69 males and 33 females, 70.1 ± 9.2 years). Total telomere and telomere G-tail lengths were measured using a hybridization protection assay. Endothelial function was evaluated by ultrasound assessment of brachial flow-mediated dilation (FMD).

Findings: Shortened telomere G-tail length was associated with age and Framingham risk score (P = 0.018 and P = 0.012). In addition, telomere G-tail length was positively correlated with FMD values (P = 0.031) and negatively with the severity of ARWMCs (P = 0.002). On multivariate regression analysis, telomere G-tail length was independently associated with FMD values (P = 0.022) and the severity of ARWMCs (P = 0.033), whereas total telomere length was not associated with these indicators.

Interpretation: Telomere G-tail length is associated with age and vascular risk factors, and might be superior to total telomere length as a marker of endothelial dysfunction and ARWMC severity.

No MeSH data available.


Related in: MedlinePlus

Relationships among telomere G-tail length, total telomere length and vascular risk factors.*P < 0.05. HT = hypertension; DM = diabetes mellitus; DL = dyslipidemia.
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f0015: Relationships among telomere G-tail length, total telomere length and vascular risk factors.*P < 0.05. HT = hypertension; DM = diabetes mellitus; DL = dyslipidemia.

Mentions: Associations between telomere G-tail length, total telomere length and traditional vascular risk factors (hypertension, diabetes mellitus and dyslipidemia) are presented in Fig. 2. Associations between total telomere length and vascular risk factors were not significantly different. In contrast, patients with diabetes mellitus had a shorter telomere G-tail length than those without (12755.4 ± 1831.2 RLU/μg DNA vs. 14027.0 ± 3025.8 RLU/μg DNA, P = 0.035). Patient characteristics according to telomere G-tail length tertile are presented in Table 2. A shorter telomere G-tail length (lowest tertile) was associated with age and a higher Framingham risk score (P = 0.018 and P = 0.012). Similarly, total telomere length (lowest tertile) was also associated with age and a higher Framingham risk score (P = 0.001 and P = 0.026) (Supplemental Table 3).


Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study.

Nezu T, Hosomi N, Takahashi T, Anno K, Aoki S, Shimamoto A, Maruyama H, Hayashi T, Matsumoto M, Tahara H - EBioMedicine (2015)

Relationships among telomere G-tail length, total telomere length and vascular risk factors.*P < 0.05. HT = hypertension; DM = diabetes mellitus; DL = dyslipidemia.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563121&req=5

f0015: Relationships among telomere G-tail length, total telomere length and vascular risk factors.*P < 0.05. HT = hypertension; DM = diabetes mellitus; DL = dyslipidemia.
Mentions: Associations between telomere G-tail length, total telomere length and traditional vascular risk factors (hypertension, diabetes mellitus and dyslipidemia) are presented in Fig. 2. Associations between total telomere length and vascular risk factors were not significantly different. In contrast, patients with diabetes mellitus had a shorter telomere G-tail length than those without (12755.4 ± 1831.2 RLU/μg DNA vs. 14027.0 ± 3025.8 RLU/μg DNA, P = 0.035). Patient characteristics according to telomere G-tail length tertile are presented in Table 2. A shorter telomere G-tail length (lowest tertile) was associated with age and a higher Framingham risk score (P = 0.018 and P = 0.012). Similarly, total telomere length (lowest tertile) was also associated with age and a higher Framingham risk score (P = 0.001 and P = 0.026) (Supplemental Table 3).

Bottom Line: Shortened telomere G-tail length was associated with age and Framingham risk score (P = 0.018 and P = 0.012).On multivariate regression analysis, telomere G-tail length was independently associated with FMD values (P = 0.022) and the severity of ARWMCs (P = 0.033), whereas total telomere length was not associated with these indicators.Telomere G-tail length is associated with age and vascular risk factors, and might be superior to total telomere length as a marker of endothelial dysfunction and ARWMC severity.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.

ABSTRACT

Background: The telomeric 3'-overhang (G-tail) length is essential for the biological effects of telomere dysfunction in vitro, but the association of length with aging and cardiovascular risk is unclear in humans. We investigated the association between the telomere G-tail length of leukocytes and cardiovascular risk, age-related white matter changes (ARWMCs), and endothelial function.

Methods: Patients with a history of cerebrovascular disease and comorbidity were enrolled (n = 102; 69 males and 33 females, 70.1 ± 9.2 years). Total telomere and telomere G-tail lengths were measured using a hybridization protection assay. Endothelial function was evaluated by ultrasound assessment of brachial flow-mediated dilation (FMD).

Findings: Shortened telomere G-tail length was associated with age and Framingham risk score (P = 0.018 and P = 0.012). In addition, telomere G-tail length was positively correlated with FMD values (P = 0.031) and negatively with the severity of ARWMCs (P = 0.002). On multivariate regression analysis, telomere G-tail length was independently associated with FMD values (P = 0.022) and the severity of ARWMCs (P = 0.033), whereas total telomere length was not associated with these indicators.

Interpretation: Telomere G-tail length is associated with age and vascular risk factors, and might be superior to total telomere length as a marker of endothelial dysfunction and ARWMC severity.

No MeSH data available.


Related in: MedlinePlus