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Biothermodynamic Assay of Coptis-Evodia Herb Couples.

Yang H, Su M, Yao Q, Zhao Y, Chen D, Jia L - Evid Based Complement Alternat Med (2015)

Bottom Line: It showed that animal retention ratio in hot pad significantly decreased along with the decrease in coptis proportion in coptis-evodia herb couples.In addition, Zuojin wan markedly reduced the retention ratio of gastritis mice in the hot pad, while Fanzuojin wan displayed an opposite result.In the gastric cells from the gastritis mice, Fanzuojin wan remarkably increased calorific value for growth and metabolism, while Zuojin wan significantly reduced the calorigenic effect.

View Article: PubMed Central - PubMed

Affiliation: Yunnan Institute of Materia Medica, Kunming 650111, China.

ABSTRACT
Objective. To illustrate the difference in cold/hot natural properties and therapeutic effect of coptis-evodia herb couples by using cold/hot plate differentiating technology and microcalorimetry combined with material basis analysis in vivo and in vitro. It showed that animal retention ratio in hot pad significantly decreased along with the decrease in coptis proportion in coptis-evodia herb couples. In addition, Zuojin wan markedly reduced the retention ratio of gastritis mice in the hot pad, while Fanzuojin wan displayed an opposite result. Further, Mg(2+)-ATPase, Ca(2+)-ATPase, and T-AOC activity significantly weakened in coptis-treated group in the livers of the mice. In the gastric cells from the gastritis mice, Fanzuojin wan remarkably increased calorific value for growth and metabolism, while Zuojin wan significantly reduced the calorigenic effect. It suggested that the changes in the major chemical compositions (especially alkaloids) were the material base-induced transformation between "cold" and "hot" syndromes. The material basis which affected the transformation between "cold" and "hot" syndromes might be X2, X3, X4, X8, epiberberine hydrochloride, jatrorrhizine hydrochloride, coptisine sulphate, palmatine hydrochloride, and berberine hydrochloride. The CHPD combined with microcalorimetry technology is a good method to determine the differences in the "cold" and "hot" natural properties of coptis-evodia herb couples.

No MeSH data available.


Related in: MedlinePlus

Retention ratio of normal mice in hot pad after the treatments of coptis-evodia herb couples. Data are presented as mean (n = 6) ± SD. ZJW: Zuojin wan; GLS: Ganlu san; ZYW: Zhuyu wan; FZJ: Fanzuojin wan. ∗P < 0.05, ∗∗P < 0.01 versus control (t-test).
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fig2: Retention ratio of normal mice in hot pad after the treatments of coptis-evodia herb couples. Data are presented as mean (n = 6) ± SD. ZJW: Zuojin wan; GLS: Ganlu san; ZYW: Zhuyu wan; FZJ: Fanzuojin wan. ∗P < 0.05, ∗∗P < 0.01 versus control (t-test).

Mentions: It is shown that the retention ratio in the hot pad decreased along with the decrease in coptis proportion in coptis-evodia herb couples. The order of the retention ratio in the hot pad was coptis > Zuojin wan > Ganlu san ≈ Zhuyu wan > Fanzuojin wan > evodia. The results demonstrated that Zuojin wan had a significant thermotaxis effect, while Fanzuojin wan and evodia markedly increased the tendency to being cold in normal mice (Figure 2).


Biothermodynamic Assay of Coptis-Evodia Herb Couples.

Yang H, Su M, Yao Q, Zhao Y, Chen D, Jia L - Evid Based Complement Alternat Med (2015)

Retention ratio of normal mice in hot pad after the treatments of coptis-evodia herb couples. Data are presented as mean (n = 6) ± SD. ZJW: Zuojin wan; GLS: Ganlu san; ZYW: Zhuyu wan; FZJ: Fanzuojin wan. ∗P < 0.05, ∗∗P < 0.01 versus control (t-test).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4563112&req=5

fig2: Retention ratio of normal mice in hot pad after the treatments of coptis-evodia herb couples. Data are presented as mean (n = 6) ± SD. ZJW: Zuojin wan; GLS: Ganlu san; ZYW: Zhuyu wan; FZJ: Fanzuojin wan. ∗P < 0.05, ∗∗P < 0.01 versus control (t-test).
Mentions: It is shown that the retention ratio in the hot pad decreased along with the decrease in coptis proportion in coptis-evodia herb couples. The order of the retention ratio in the hot pad was coptis > Zuojin wan > Ganlu san ≈ Zhuyu wan > Fanzuojin wan > evodia. The results demonstrated that Zuojin wan had a significant thermotaxis effect, while Fanzuojin wan and evodia markedly increased the tendency to being cold in normal mice (Figure 2).

Bottom Line: It showed that animal retention ratio in hot pad significantly decreased along with the decrease in coptis proportion in coptis-evodia herb couples.In addition, Zuojin wan markedly reduced the retention ratio of gastritis mice in the hot pad, while Fanzuojin wan displayed an opposite result.In the gastric cells from the gastritis mice, Fanzuojin wan remarkably increased calorific value for growth and metabolism, while Zuojin wan significantly reduced the calorigenic effect.

View Article: PubMed Central - PubMed

Affiliation: Yunnan Institute of Materia Medica, Kunming 650111, China.

ABSTRACT
Objective. To illustrate the difference in cold/hot natural properties and therapeutic effect of coptis-evodia herb couples by using cold/hot plate differentiating technology and microcalorimetry combined with material basis analysis in vivo and in vitro. It showed that animal retention ratio in hot pad significantly decreased along with the decrease in coptis proportion in coptis-evodia herb couples. In addition, Zuojin wan markedly reduced the retention ratio of gastritis mice in the hot pad, while Fanzuojin wan displayed an opposite result. Further, Mg(2+)-ATPase, Ca(2+)-ATPase, and T-AOC activity significantly weakened in coptis-treated group in the livers of the mice. In the gastric cells from the gastritis mice, Fanzuojin wan remarkably increased calorific value for growth and metabolism, while Zuojin wan significantly reduced the calorigenic effect. It suggested that the changes in the major chemical compositions (especially alkaloids) were the material base-induced transformation between "cold" and "hot" syndromes. The material basis which affected the transformation between "cold" and "hot" syndromes might be X2, X3, X4, X8, epiberberine hydrochloride, jatrorrhizine hydrochloride, coptisine sulphate, palmatine hydrochloride, and berberine hydrochloride. The CHPD combined with microcalorimetry technology is a good method to determine the differences in the "cold" and "hot" natural properties of coptis-evodia herb couples.

No MeSH data available.


Related in: MedlinePlus