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Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits.

Zafar F, Jahan N - Evid Based Complement Alternat Med (2015)

Bottom Line: The present study was designed to develop safer, effective, and viable cardioprotective herbal combination to control oxidative stress related cardiac ailments as new alternatives to synthetic drugs.Rabbits administrated with mere salbutamol showed a significant increase in cardiac marker enzymes and lipid profile and decrease in antioxidant enzymes as compared to normal control indicating cardiotoxicity and myocardial cell necrosis.Histopathological examination confirmed that the said combination was safer cardioprotective product.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Agriculture, Faisalabad 38000, Pakistan.

ABSTRACT
The present study was designed to develop safer, effective, and viable cardioprotective herbal combination to control oxidative stress related cardiac ailments as new alternatives to synthetic drugs. The synergetic cardioprotective potential of herbal combination of four plants T. arjuna (T.A.), P. nigrum (P.N), C. grandiflorus (C), and C. oxyacantha (Cr) was assessed through curative and preventive mode of treatment. In preventive mode of treatment, the cardiac injury was induced with synthetic catecholamine (salbutamol) to pretreated rabbits with the proposed herbal combination for three weeks. In curative mode of treatment, cardiotoxicity/oxidative stress was induced in rabbits with salbutamol prior to treating them with plant mixture. Cardiac marker enzymes, lipids profile, and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals. Rabbits administrated with mere salbutamol showed a significant increase in cardiac marker enzymes and lipid profile and decrease in antioxidant enzymes as compared to normal control indicating cardiotoxicity and myocardial cell necrosis. However, pre- and postadministration of plant mixture appreciably restored the levels of all biomarkers. Histopathological examination confirmed that the said combination was safer cardioprotective product.

No MeSH data available.


Related in: MedlinePlus

Histopathological architecture of heart of different experimental groups.
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Related In: Results  -  Collection


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fig2: Histopathological architecture of heart of different experimental groups.

Mentions: The histopathological architecture of heart from different experimental groups showed series of variations (Figure 2). In the normal control group, myocardial fibers were arranged regularly with clear striation. No apparent degeneration or necrosis was observed (Figure 2(a)). Histological section of salbutamol treated heart showed severe necrotic and degenerative changes and hyperchromatic and pyknotic nuclei as well as fibroblastic hyperplasia and thick connective tissue proliferation (Figure 2(b)). Heart tissues were normal in rabbits treated with herbal combination. Mild necrotic changes in cardiomyocytes were observed in curative mode of treatment (Figure 2(c)). An insignificant necrosis was examined in the heart of preventive group (Figure 2(d)). Rabbits of base line group also showed normal results.


Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits.

Zafar F, Jahan N - Evid Based Complement Alternat Med (2015)

Histopathological architecture of heart of different experimental groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4563096&req=5

fig2: Histopathological architecture of heart of different experimental groups.
Mentions: The histopathological architecture of heart from different experimental groups showed series of variations (Figure 2). In the normal control group, myocardial fibers were arranged regularly with clear striation. No apparent degeneration or necrosis was observed (Figure 2(a)). Histological section of salbutamol treated heart showed severe necrotic and degenerative changes and hyperchromatic and pyknotic nuclei as well as fibroblastic hyperplasia and thick connective tissue proliferation (Figure 2(b)). Heart tissues were normal in rabbits treated with herbal combination. Mild necrotic changes in cardiomyocytes were observed in curative mode of treatment (Figure 2(c)). An insignificant necrosis was examined in the heart of preventive group (Figure 2(d)). Rabbits of base line group also showed normal results.

Bottom Line: The present study was designed to develop safer, effective, and viable cardioprotective herbal combination to control oxidative stress related cardiac ailments as new alternatives to synthetic drugs.Rabbits administrated with mere salbutamol showed a significant increase in cardiac marker enzymes and lipid profile and decrease in antioxidant enzymes as compared to normal control indicating cardiotoxicity and myocardial cell necrosis.Histopathological examination confirmed that the said combination was safer cardioprotective product.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Agriculture, Faisalabad 38000, Pakistan.

ABSTRACT
The present study was designed to develop safer, effective, and viable cardioprotective herbal combination to control oxidative stress related cardiac ailments as new alternatives to synthetic drugs. The synergetic cardioprotective potential of herbal combination of four plants T. arjuna (T.A.), P. nigrum (P.N), C. grandiflorus (C), and C. oxyacantha (Cr) was assessed through curative and preventive mode of treatment. In preventive mode of treatment, the cardiac injury was induced with synthetic catecholamine (salbutamol) to pretreated rabbits with the proposed herbal combination for three weeks. In curative mode of treatment, cardiotoxicity/oxidative stress was induced in rabbits with salbutamol prior to treating them with plant mixture. Cardiac marker enzymes, lipids profile, and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals. Rabbits administrated with mere salbutamol showed a significant increase in cardiac marker enzymes and lipid profile and decrease in antioxidant enzymes as compared to normal control indicating cardiotoxicity and myocardial cell necrosis. However, pre- and postadministration of plant mixture appreciably restored the levels of all biomarkers. Histopathological examination confirmed that the said combination was safer cardioprotective product.

No MeSH data available.


Related in: MedlinePlus