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Is there a relationship between the severity of erectile dysfunction and the comorbidity profile in men with late onset hypogonadism?

Yassin AA, Nettleship JE, Almehmadi Y, Yassin DJ, El Douaihy Y, Saad F - Arab J Urol (2015)

Bottom Line: There was a significant association between the severity of ED and mean weight (P < 0.001), waist circumference (P < 0.001), triglycerides (P = 0.009), total cholesterol (P = 0.027), HbA1c (P < 0.001), fasting glucose (P = 0.003) and AMS scores (P = 0.043).The descriptive data showed that a greater severity of ED in men with LOH correlated with an increased waist circumference, hyperglycaemia, hypertriglyceridaemia, hyperlipidaemia, and a history of diabetes mellitus.Severe ED is a prognostic indicator of comorbidities in men with LOH.

View Article: PubMed Central - PubMed

Affiliation: Institute of Urology/Andrology, Norderstedt-Hamburg, Germany ; Dresden International University, Dresden, Germany ; Gulf Medical University School of Medicine, Ajman, United Arab Emirates.

ABSTRACT

Objective: To determine whether the severity of erectile dysfunction (ED) in a man diagnosed with late-onset hypogonadism (LOH) gives information about his metabolic syndrome state, as patients with LOH often have sexual symptoms and associated cardiovascular and metabolic comorbidities, but the role of ED in predicting the prevalence of comorbid disease in men with low levels of testosterone is currently unknown.

Patients and methods: Men (130) diagnosed with LOH and fulfilling the criteria of a total testosterone level of <3.5 ng/mL (<12 nmol/L), and with an erectile function domain score of <21 on the International Index of Erectile Function questionnaire (IIEF, questions 1-5), were enrolled for a subsequent trial of supplementation with testosterone undecanoate. Demographic data were recorded at baseline. The men completed three standardised questionnaires to assess sexual health, including the International Prostate Symptom Score, Ageing Males Symptoms (AMS) and IIEF Sexual Health Inventory for Men (SHIM). Patients were stratified by the severity of ED, with SHIM scores of 1-7 considered severe, 8-11 moderate, and 12-16 mild to moderate. Levels of serum testosterone, sex hormone binding globulin (SHBG) and lipids (total cholesterol, triglycerides, high-density and low-density lipoprotein) were assessed, along with plasma fasting glucose and glycated haemoglobin (HbA1c) levels. Body weight, body mass index and waist circumference were also recorded.

Results: There was a significant association between the severity of ED and mean weight (P < 0.001), waist circumference (P < 0.001), triglycerides (P = 0.009), total cholesterol (P = 0.027), HbA1c (P < 0.001), fasting glucose (P = 0.003) and AMS scores (P = 0.043). There were no significant differences in testosterone fractions and SHBG levels between the ED subgroups. There was a positive correlation between the prevalence of diabetes mellitus (type 1 and type 2) and the severity of ED in these men (P = 0.018).

Conclusions: The descriptive data showed that a greater severity of ED in men with LOH correlated with an increased waist circumference, hyperglycaemia, hypertriglyceridaemia, hyperlipidaemia, and a history of diabetes mellitus. Severe ED is a prognostic indicator of comorbidities in men with LOH.

No MeSH data available.


Related in: MedlinePlus

Box-plot presentation of the independent variables with significant differences among the ED subgroups by One Way ANOVA analysis.
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f0005: Box-plot presentation of the independent variables with significant differences among the ED subgroups by One Way ANOVA analysis.

Mentions: Comparing the means of the ED subgroups by one-way ANOVA there were no correlations with severity and any measure of the hormonal panel (serum total testosterone and SHBG, and calculated free and bioavailable testosterone) (Table 2). Of the continuous variables the one-way ANOVA showed that the means of body weight, waist circumference, fasting glucose, HbA1c, triglycerides and AMS were directly proportional to the severity of ED, with statistical significance (Table 3 and Fig. 1).


Is there a relationship between the severity of erectile dysfunction and the comorbidity profile in men with late onset hypogonadism?

Yassin AA, Nettleship JE, Almehmadi Y, Yassin DJ, El Douaihy Y, Saad F - Arab J Urol (2015)

Box-plot presentation of the independent variables with significant differences among the ED subgroups by One Way ANOVA analysis.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4563011&req=5

f0005: Box-plot presentation of the independent variables with significant differences among the ED subgroups by One Way ANOVA analysis.
Mentions: Comparing the means of the ED subgroups by one-way ANOVA there were no correlations with severity and any measure of the hormonal panel (serum total testosterone and SHBG, and calculated free and bioavailable testosterone) (Table 2). Of the continuous variables the one-way ANOVA showed that the means of body weight, waist circumference, fasting glucose, HbA1c, triglycerides and AMS were directly proportional to the severity of ED, with statistical significance (Table 3 and Fig. 1).

Bottom Line: There was a significant association between the severity of ED and mean weight (P < 0.001), waist circumference (P < 0.001), triglycerides (P = 0.009), total cholesterol (P = 0.027), HbA1c (P < 0.001), fasting glucose (P = 0.003) and AMS scores (P = 0.043).The descriptive data showed that a greater severity of ED in men with LOH correlated with an increased waist circumference, hyperglycaemia, hypertriglyceridaemia, hyperlipidaemia, and a history of diabetes mellitus.Severe ED is a prognostic indicator of comorbidities in men with LOH.

View Article: PubMed Central - PubMed

Affiliation: Institute of Urology/Andrology, Norderstedt-Hamburg, Germany ; Dresden International University, Dresden, Germany ; Gulf Medical University School of Medicine, Ajman, United Arab Emirates.

ABSTRACT

Objective: To determine whether the severity of erectile dysfunction (ED) in a man diagnosed with late-onset hypogonadism (LOH) gives information about his metabolic syndrome state, as patients with LOH often have sexual symptoms and associated cardiovascular and metabolic comorbidities, but the role of ED in predicting the prevalence of comorbid disease in men with low levels of testosterone is currently unknown.

Patients and methods: Men (130) diagnosed with LOH and fulfilling the criteria of a total testosterone level of <3.5 ng/mL (<12 nmol/L), and with an erectile function domain score of <21 on the International Index of Erectile Function questionnaire (IIEF, questions 1-5), were enrolled for a subsequent trial of supplementation with testosterone undecanoate. Demographic data were recorded at baseline. The men completed three standardised questionnaires to assess sexual health, including the International Prostate Symptom Score, Ageing Males Symptoms (AMS) and IIEF Sexual Health Inventory for Men (SHIM). Patients were stratified by the severity of ED, with SHIM scores of 1-7 considered severe, 8-11 moderate, and 12-16 mild to moderate. Levels of serum testosterone, sex hormone binding globulin (SHBG) and lipids (total cholesterol, triglycerides, high-density and low-density lipoprotein) were assessed, along with plasma fasting glucose and glycated haemoglobin (HbA1c) levels. Body weight, body mass index and waist circumference were also recorded.

Results: There was a significant association between the severity of ED and mean weight (P < 0.001), waist circumference (P < 0.001), triglycerides (P = 0.009), total cholesterol (P = 0.027), HbA1c (P < 0.001), fasting glucose (P = 0.003) and AMS scores (P = 0.043). There were no significant differences in testosterone fractions and SHBG levels between the ED subgroups. There was a positive correlation between the prevalence of diabetes mellitus (type 1 and type 2) and the severity of ED in these men (P = 0.018).

Conclusions: The descriptive data showed that a greater severity of ED in men with LOH correlated with an increased waist circumference, hyperglycaemia, hypertriglyceridaemia, hyperlipidaemia, and a history of diabetes mellitus. Severe ED is a prognostic indicator of comorbidities in men with LOH.

No MeSH data available.


Related in: MedlinePlus