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The effectiveness of low-level diode laser therapy on orthodontic pain management: a systematic review and meta-analysis.

Ren C, McGrath C, Yang Y - Lasers Med Sci (2015)

Bottom Line: Of the 186 results, 14 RCTs, with a total of 659 participants from 11 countries, were included.Except for three studies assessed as having a 'moderate risk of bias', the RCTs were rated as having a 'high risk of bias'.However, no significant effects were shown for split-mouth-design studies (P = 0.38 versus placebo groups).

View Article: PubMed Central - PubMed

Affiliation: Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, China.

ABSTRACT
To assess the effectiveness of diode low-level laser therapy (LLLT) for orthodontic pain control, a systematic and extensive electronic search for randomised controlled trials (RCTs) investigating the effects of diode LLLT on orthodontic pain prior to November 2014 was performed using the Cochrane Library (Issue 9, 2014), PubMed (1997), EMBASE (1947) and Web of Science (1956). The Cochrane tool for risk of bias evaluation was used to assess the bias risk in the chosen data. A meta-analysis was conducted using RevMan 5.3. Of the 186 results, 14 RCTs, with a total of 659 participants from 11 countries, were included. Except for three studies assessed as having a 'moderate risk of bias', the RCTs were rated as having a 'high risk of bias'. The methodological weaknesses were mainly due to 'blinding' and 'allocation concealment'. The meta-analysis showed that diode LLLT significantly reduced orthodontic pain by 39 % in comparison with placebo groups (P = 0.02). Diode LLLT was shown to significantly reduce the maximum pain intensity among parallel-design studies (P = 0.003 versus placebo groups; P = 0.000 versus control groups). However, no significant effects were shown for split-mouth-design studies (P = 0.38 versus placebo groups). It was concluded that the use of diode LLLT for orthodontic pain appears promising. However, due to methodological weaknesses, there was insufficient evidence to support or refute LLLT's effectiveness. RCTs with better designs and appropriate sample power are required to provide stronger evidence for diode LLLT's clinical applications.

No MeSH data available.


Related in: MedlinePlus

PRISMA flow diagram of the study inclusion process
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Related In: Results  -  Collection


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Fig1: PRISMA flow diagram of the study inclusion process

Mentions: Initially, 186 studies were identified through the electronic search, of which 99 studies remained after removing duplicates. During the first stage, 76 studies were excluded based on the evaluation of the titles and abstracts (inter-reviewer agreement, kappa = 0.91). In the second stage, after screening the full-text articles of the remaining 23 studies, a total of 14 eligible studies were included for the systematic review (inter-reviewer agreement, kappa = 0.94) [36–49]. The whole selection process is shown in Fig. 1.Fig. 1


The effectiveness of low-level diode laser therapy on orthodontic pain management: a systematic review and meta-analysis.

Ren C, McGrath C, Yang Y - Lasers Med Sci (2015)

PRISMA flow diagram of the study inclusion process
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4562996&req=5

Fig1: PRISMA flow diagram of the study inclusion process
Mentions: Initially, 186 studies were identified through the electronic search, of which 99 studies remained after removing duplicates. During the first stage, 76 studies were excluded based on the evaluation of the titles and abstracts (inter-reviewer agreement, kappa = 0.91). In the second stage, after screening the full-text articles of the remaining 23 studies, a total of 14 eligible studies were included for the systematic review (inter-reviewer agreement, kappa = 0.94) [36–49]. The whole selection process is shown in Fig. 1.Fig. 1

Bottom Line: Of the 186 results, 14 RCTs, with a total of 659 participants from 11 countries, were included.Except for three studies assessed as having a 'moderate risk of bias', the RCTs were rated as having a 'high risk of bias'.However, no significant effects were shown for split-mouth-design studies (P = 0.38 versus placebo groups).

View Article: PubMed Central - PubMed

Affiliation: Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, China.

ABSTRACT
To assess the effectiveness of diode low-level laser therapy (LLLT) for orthodontic pain control, a systematic and extensive electronic search for randomised controlled trials (RCTs) investigating the effects of diode LLLT on orthodontic pain prior to November 2014 was performed using the Cochrane Library (Issue 9, 2014), PubMed (1997), EMBASE (1947) and Web of Science (1956). The Cochrane tool for risk of bias evaluation was used to assess the bias risk in the chosen data. A meta-analysis was conducted using RevMan 5.3. Of the 186 results, 14 RCTs, with a total of 659 participants from 11 countries, were included. Except for three studies assessed as having a 'moderate risk of bias', the RCTs were rated as having a 'high risk of bias'. The methodological weaknesses were mainly due to 'blinding' and 'allocation concealment'. The meta-analysis showed that diode LLLT significantly reduced orthodontic pain by 39 % in comparison with placebo groups (P = 0.02). Diode LLLT was shown to significantly reduce the maximum pain intensity among parallel-design studies (P = 0.003 versus placebo groups; P = 0.000 versus control groups). However, no significant effects were shown for split-mouth-design studies (P = 0.38 versus placebo groups). It was concluded that the use of diode LLLT for orthodontic pain appears promising. However, due to methodological weaknesses, there was insufficient evidence to support or refute LLLT's effectiveness. RCTs with better designs and appropriate sample power are required to provide stronger evidence for diode LLLT's clinical applications.

No MeSH data available.


Related in: MedlinePlus