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Cue reactivity and its relation to craving and relapse in alcohol dependence: a combined laboratory and field study.

Witteman J, Post H, Tarvainen M, de Bruijn A, Perna Ede S, Ramaekers JG, Wiers RW - Psychopharmacology (Berl.) (2015)

Bottom Line: The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving.Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence.It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Humanities, Leiden University Center for Linguistics, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands, witteman.j@gmail.com.

ABSTRACT
The present study investigated the nature of physiological cue reactivity and craving in response to alcohol cues among alcohol-dependent patients (N = 80) who were enrolled in detoxification treatment. Further, the predictive value with regard to future drinking of both the magnitude of the physiological and craving response to alcohol cues while in treatment and the degree of alcohol-cue exposure in patients' natural environment was assessed. Physiological reactivity and craving in response to experimental exposure to alcohol and soft drink advertisements were measured during detoxification treatment using heart rate variability and subjective rating of craving. Following discharge, patients monitored exposure to alcohol advertisements for five consecutive weeks with a diary and were followed up with an assessment of relapse at 5 weeks and 3 months post-discharge. The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving. Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence. Further, patients reported a substantial daily exposure to alcohol cues. The magnitude of cue reactivity and the craving response to alcohol cues at baseline and degree of exposure to alcohol cues in patients' natural environment did not predict relapse. It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.

No MeSH data available.


Related in: MedlinePlus

Scatterplot of the increase in EVHRV HF power during alcohol-cue exposure (as compared to pre-cue baseline) in alcohol advertisement (y-axis) against the craving scores after exposure to alcohol advertisement (x-axis)
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Related In: Results  -  Collection


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Fig3: Scatterplot of the increase in EVHRV HF power during alcohol-cue exposure (as compared to pre-cue baseline) in alcohol advertisement (y-axis) against the craving scores after exposure to alcohol advertisement (x-axis)

Mentions: Exploratory Spearman correlations indicated no significant correlation between the difference in craving after alcohol ads as compared to soft drink ads (i.e., relative craving) and the difference in mean HF HRV between the two blocks of advertisement (r = −0.04, N = 67, NS). Relative craving did not correlate significantly with the number of DSM-IV alcohol-dependence symptoms reported (r = 0.173, N = 76, NS) but absolute craving after alcohol-advertisement exposure showed a significant positive relationship (r = 0.252, N = 76, p = 0.028), indicating that higher craving levels were associated with more severe alcohol dependence. Furthermore, the increase in absolute EVHRV HF power during the presentation of alcohol cues (as compared to pre-cue baseline) showed a significant positive correlation with absolute craving after alcohol-advertisement exposure (r = 0.33, N = 71, p = 0.004), as can be seen in Fig. 3. Additionally, duration of problem drinking (number of problem-drinking years) correlated with increase in EVHRV HF power during the presentation of alcohol cues (r = −.26, N = 71, p = 0.03). Because age significantly correlated with the number of problem-drinking years, we performed a multiple linear regression analysis with age and number of problem-drinking years as predictors and EVHRV HF power cue reactivity as a dependent variable, revealing that only number of problem-drinking years was significantly negatively associated with cue reactivity. As can be seen in Fig. 4, the increase in EVHRV HF power was larger for patients with shorter histories of problematic drinking. Severity of alcohol dependence in the previous year (AUDIT) did not correlate with EVHRV HF power during presentation of alcohol cues.Fig. 3


Cue reactivity and its relation to craving and relapse in alcohol dependence: a combined laboratory and field study.

Witteman J, Post H, Tarvainen M, de Bruijn A, Perna Ede S, Ramaekers JG, Wiers RW - Psychopharmacology (Berl.) (2015)

Scatterplot of the increase in EVHRV HF power during alcohol-cue exposure (as compared to pre-cue baseline) in alcohol advertisement (y-axis) against the craving scores after exposure to alcohol advertisement (x-axis)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4562995&req=5

Fig3: Scatterplot of the increase in EVHRV HF power during alcohol-cue exposure (as compared to pre-cue baseline) in alcohol advertisement (y-axis) against the craving scores after exposure to alcohol advertisement (x-axis)
Mentions: Exploratory Spearman correlations indicated no significant correlation between the difference in craving after alcohol ads as compared to soft drink ads (i.e., relative craving) and the difference in mean HF HRV between the two blocks of advertisement (r = −0.04, N = 67, NS). Relative craving did not correlate significantly with the number of DSM-IV alcohol-dependence symptoms reported (r = 0.173, N = 76, NS) but absolute craving after alcohol-advertisement exposure showed a significant positive relationship (r = 0.252, N = 76, p = 0.028), indicating that higher craving levels were associated with more severe alcohol dependence. Furthermore, the increase in absolute EVHRV HF power during the presentation of alcohol cues (as compared to pre-cue baseline) showed a significant positive correlation with absolute craving after alcohol-advertisement exposure (r = 0.33, N = 71, p = 0.004), as can be seen in Fig. 3. Additionally, duration of problem drinking (number of problem-drinking years) correlated with increase in EVHRV HF power during the presentation of alcohol cues (r = −.26, N = 71, p = 0.03). Because age significantly correlated with the number of problem-drinking years, we performed a multiple linear regression analysis with age and number of problem-drinking years as predictors and EVHRV HF power cue reactivity as a dependent variable, revealing that only number of problem-drinking years was significantly negatively associated with cue reactivity. As can be seen in Fig. 4, the increase in EVHRV HF power was larger for patients with shorter histories of problematic drinking. Severity of alcohol dependence in the previous year (AUDIT) did not correlate with EVHRV HF power during presentation of alcohol cues.Fig. 3

Bottom Line: The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving.Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence.It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Humanities, Leiden University Center for Linguistics, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands, witteman.j@gmail.com.

ABSTRACT
The present study investigated the nature of physiological cue reactivity and craving in response to alcohol cues among alcohol-dependent patients (N = 80) who were enrolled in detoxification treatment. Further, the predictive value with regard to future drinking of both the magnitude of the physiological and craving response to alcohol cues while in treatment and the degree of alcohol-cue exposure in patients' natural environment was assessed. Physiological reactivity and craving in response to experimental exposure to alcohol and soft drink advertisements were measured during detoxification treatment using heart rate variability and subjective rating of craving. Following discharge, patients monitored exposure to alcohol advertisements for five consecutive weeks with a diary and were followed up with an assessment of relapse at 5 weeks and 3 months post-discharge. The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving. Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence. Further, patients reported a substantial daily exposure to alcohol cues. The magnitude of cue reactivity and the craving response to alcohol cues at baseline and degree of exposure to alcohol cues in patients' natural environment did not predict relapse. It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.

No MeSH data available.


Related in: MedlinePlus