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Cue reactivity and its relation to craving and relapse in alcohol dependence: a combined laboratory and field study.

Witteman J, Post H, Tarvainen M, de Bruijn A, Perna Ede S, Ramaekers JG, Wiers RW - Psychopharmacology (Berl.) (2015)

Bottom Line: The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving.Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence.It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Humanities, Leiden University Center for Linguistics, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands, witteman.j@gmail.com.

ABSTRACT
The present study investigated the nature of physiological cue reactivity and craving in response to alcohol cues among alcohol-dependent patients (N = 80) who were enrolled in detoxification treatment. Further, the predictive value with regard to future drinking of both the magnitude of the physiological and craving response to alcohol cues while in treatment and the degree of alcohol-cue exposure in patients' natural environment was assessed. Physiological reactivity and craving in response to experimental exposure to alcohol and soft drink advertisements were measured during detoxification treatment using heart rate variability and subjective rating of craving. Following discharge, patients monitored exposure to alcohol advertisements for five consecutive weeks with a diary and were followed up with an assessment of relapse at 5 weeks and 3 months post-discharge. The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving. Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence. Further, patients reported a substantial daily exposure to alcohol cues. The magnitude of cue reactivity and the craving response to alcohol cues at baseline and degree of exposure to alcohol cues in patients' natural environment did not predict relapse. It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.

No MeSH data available.


Related in: MedlinePlus

Mean craving score after alcohol and soft drink advertisement exposure. Error bars indicate the 95 % confidence interval
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Fig2: Mean craving score after alcohol and soft drink advertisement exposure. Error bars indicate the 95 % confidence interval

Mentions: Craving VAS-scores after soft drink and alcohol-advertisement exposure were available for 79 patients. Wilcoxon Signed-ranks test indicated a significantly higher craving level after exposure to an alcohol (Mdn = 14) advertisement as compared to the level of craving after a soft drink (Mdn = 5) advertisement (Z = 5.54, p < 0.001), corresponding to a large effect size (partial eta2 = 0.29). There was large variation in the craving response among patients, as indicated by a relatively high standard deviation (SD = 18.30). However, in absolute terms, craving after alcohol-advertisement exposure was relatively low (see Fig. 2). Further, 38.8 % of patients did not show a higher craving level after alcohol-advertisement exposure as compared to craving after soda-advertisement exposure. Finally, a chi-square test to test whether the order in which the advertisement blocks were presented (alcohol first versus soft drink first) influenced whether participants showed a craving response or not did not reveal an order effect X2(1, N = 79) = 0.18, NS.Fig. 2


Cue reactivity and its relation to craving and relapse in alcohol dependence: a combined laboratory and field study.

Witteman J, Post H, Tarvainen M, de Bruijn A, Perna Ede S, Ramaekers JG, Wiers RW - Psychopharmacology (Berl.) (2015)

Mean craving score after alcohol and soft drink advertisement exposure. Error bars indicate the 95 % confidence interval
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4562995&req=5

Fig2: Mean craving score after alcohol and soft drink advertisement exposure. Error bars indicate the 95 % confidence interval
Mentions: Craving VAS-scores after soft drink and alcohol-advertisement exposure were available for 79 patients. Wilcoxon Signed-ranks test indicated a significantly higher craving level after exposure to an alcohol (Mdn = 14) advertisement as compared to the level of craving after a soft drink (Mdn = 5) advertisement (Z = 5.54, p < 0.001), corresponding to a large effect size (partial eta2 = 0.29). There was large variation in the craving response among patients, as indicated by a relatively high standard deviation (SD = 18.30). However, in absolute terms, craving after alcohol-advertisement exposure was relatively low (see Fig. 2). Further, 38.8 % of patients did not show a higher craving level after alcohol-advertisement exposure as compared to craving after soda-advertisement exposure. Finally, a chi-square test to test whether the order in which the advertisement blocks were presented (alcohol first versus soft drink first) influenced whether participants showed a craving response or not did not reveal an order effect X2(1, N = 79) = 0.18, NS.Fig. 2

Bottom Line: The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving.Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence.It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Humanities, Leiden University Center for Linguistics, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands, witteman.j@gmail.com.

ABSTRACT
The present study investigated the nature of physiological cue reactivity and craving in response to alcohol cues among alcohol-dependent patients (N = 80) who were enrolled in detoxification treatment. Further, the predictive value with regard to future drinking of both the magnitude of the physiological and craving response to alcohol cues while in treatment and the degree of alcohol-cue exposure in patients' natural environment was assessed. Physiological reactivity and craving in response to experimental exposure to alcohol and soft drink advertisements were measured during detoxification treatment using heart rate variability and subjective rating of craving. Following discharge, patients monitored exposure to alcohol advertisements for five consecutive weeks with a diary and were followed up with an assessment of relapse at 5 weeks and 3 months post-discharge. The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving. Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence. Further, patients reported a substantial daily exposure to alcohol cues. The magnitude of cue reactivity and the craving response to alcohol cues at baseline and degree of exposure to alcohol cues in patients' natural environment did not predict relapse. It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.

No MeSH data available.


Related in: MedlinePlus