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The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test.

Kim YC, Kim JH, Cheung DY, Kim TH, Jun EJ, Oh JW, Kim CW, Chung WC, Kim BW, Kim SS, Kim JI, Park SH, Kim JK - Gut Liver (2015)

Bottom Line: For adenomatous lesions, the sensitivity of iM2-PK was 69.4%, which was also superior to iFOBT (12.1%, p<0.001).The iM2-PK exhibited increased sensitivity for identifying CRC and adenomatous lesions compared with iFOBT.Given its rapid results and convenience, CRC screening using iM2-PK is promising.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.

ABSTRACT

Background/aims: M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions.

Methods: Healthy volunteers and patients with colorectal neoplasia were enrolled in six academic hospitals in the capital province of Korea. The iM2-PK value was compared with the immunochromatographic fecal occult blood test (iFOBT) and fecal tumor M2-PK enzyme-linked immunosorbent assay (ELISA).

Results: A total of 323 subjects were enrolled. The sensitivity of iM2-PK for CRC was 92.8%, which was superior to iFOBT (47.5%, p<0.0001). For adenomatous lesions, the sensitivity of iM2-PK was 69.4%, which was also superior to iFOBT (12.1%, p<0.001). Compared with M2-PK ELISA, iM2-PK exhibited significantly enhanced sensitivity for CRC (97.5% vs 80.0%, p=0.0289). The sensitivity of iM2-PK was higher in advanced stages of CRC compared with cancers confined to the mucosa and submucosa (p<0.05). However, lymph node metastasis had no influence on the sensitivity of iM2-PK.

Conclusions: The iM2-PK exhibited increased sensitivity for identifying CRC and adenomatous lesions compared with iFOBT. Given its rapid results and convenience, CRC screening using iM2-PK is promising.

No MeSH data available.


Related in: MedlinePlus

The sensitivity of immunochromatographic M2 pyruvate kinase (iM2-PK) according to cancer stages based on Dukes and TNM classification. The sensitivity of iM2-PK of Dukes A stage cancer was 80.6%. Cancers classified as Dukes B and Dukes C stages exhibited sensitivity of 100% and 94.8%, respectively. These values were significantly increased compared with cancers categorized as Dukes A stage (p<0.05). Similarly, cancers that were T2 or beyond exhibited significantly increased positivity compared with Tis and T1 cancers. The sensitivity for Tis and T1 cancers was 82.8%, and the sensitivity for T2, T3, and T4 cancers was 95.1% (p=0.019).CI, confidence interval. *p<0.05.
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f2-gnl-09-641: The sensitivity of immunochromatographic M2 pyruvate kinase (iM2-PK) according to cancer stages based on Dukes and TNM classification. The sensitivity of iM2-PK of Dukes A stage cancer was 80.6%. Cancers classified as Dukes B and Dukes C stages exhibited sensitivity of 100% and 94.8%, respectively. These values were significantly increased compared with cancers categorized as Dukes A stage (p<0.05). Similarly, cancers that were T2 or beyond exhibited significantly increased positivity compared with Tis and T1 cancers. The sensitivity for Tis and T1 cancers was 82.8%, and the sensitivity for T2, T3, and T4 cancers was 95.1% (p=0.019).CI, confidence interval. *p<0.05.

Mentions: A total of 139 patients with CRC were classified into three groups according to Dukes staging: 31 patients with Dukes A, 31 patients with Dukes B, and 77 patients with Dukes C. The sensitivity of iM2-PK according to Dukes staging were 80.6% in Dukes A, 100.0% in Dukes B, and 94.8% in Dukes C. The sensitivities of Dukes B and Dukes C were significantly higher than that of Dukes A (p<0.05) (Fig. 2).


The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test.

Kim YC, Kim JH, Cheung DY, Kim TH, Jun EJ, Oh JW, Kim CW, Chung WC, Kim BW, Kim SS, Kim JI, Park SH, Kim JK - Gut Liver (2015)

The sensitivity of immunochromatographic M2 pyruvate kinase (iM2-PK) according to cancer stages based on Dukes and TNM classification. The sensitivity of iM2-PK of Dukes A stage cancer was 80.6%. Cancers classified as Dukes B and Dukes C stages exhibited sensitivity of 100% and 94.8%, respectively. These values were significantly increased compared with cancers categorized as Dukes A stage (p<0.05). Similarly, cancers that were T2 or beyond exhibited significantly increased positivity compared with Tis and T1 cancers. The sensitivity for Tis and T1 cancers was 82.8%, and the sensitivity for T2, T3, and T4 cancers was 95.1% (p=0.019).CI, confidence interval. *p<0.05.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562782&req=5

f2-gnl-09-641: The sensitivity of immunochromatographic M2 pyruvate kinase (iM2-PK) according to cancer stages based on Dukes and TNM classification. The sensitivity of iM2-PK of Dukes A stage cancer was 80.6%. Cancers classified as Dukes B and Dukes C stages exhibited sensitivity of 100% and 94.8%, respectively. These values were significantly increased compared with cancers categorized as Dukes A stage (p<0.05). Similarly, cancers that were T2 or beyond exhibited significantly increased positivity compared with Tis and T1 cancers. The sensitivity for Tis and T1 cancers was 82.8%, and the sensitivity for T2, T3, and T4 cancers was 95.1% (p=0.019).CI, confidence interval. *p<0.05.
Mentions: A total of 139 patients with CRC were classified into three groups according to Dukes staging: 31 patients with Dukes A, 31 patients with Dukes B, and 77 patients with Dukes C. The sensitivity of iM2-PK according to Dukes staging were 80.6% in Dukes A, 100.0% in Dukes B, and 94.8% in Dukes C. The sensitivities of Dukes B and Dukes C were significantly higher than that of Dukes A (p<0.05) (Fig. 2).

Bottom Line: For adenomatous lesions, the sensitivity of iM2-PK was 69.4%, which was also superior to iFOBT (12.1%, p<0.001).The iM2-PK exhibited increased sensitivity for identifying CRC and adenomatous lesions compared with iFOBT.Given its rapid results and convenience, CRC screening using iM2-PK is promising.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.

ABSTRACT

Background/aims: M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions.

Methods: Healthy volunteers and patients with colorectal neoplasia were enrolled in six academic hospitals in the capital province of Korea. The iM2-PK value was compared with the immunochromatographic fecal occult blood test (iFOBT) and fecal tumor M2-PK enzyme-linked immunosorbent assay (ELISA).

Results: A total of 323 subjects were enrolled. The sensitivity of iM2-PK for CRC was 92.8%, which was superior to iFOBT (47.5%, p<0.0001). For adenomatous lesions, the sensitivity of iM2-PK was 69.4%, which was also superior to iFOBT (12.1%, p<0.001). Compared with M2-PK ELISA, iM2-PK exhibited significantly enhanced sensitivity for CRC (97.5% vs 80.0%, p=0.0289). The sensitivity of iM2-PK was higher in advanced stages of CRC compared with cancers confined to the mucosa and submucosa (p<0.05). However, lymph node metastasis had no influence on the sensitivity of iM2-PK.

Conclusions: The iM2-PK exhibited increased sensitivity for identifying CRC and adenomatous lesions compared with iFOBT. Given its rapid results and convenience, CRC screening using iM2-PK is promising.

No MeSH data available.


Related in: MedlinePlus