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Inorganic nanolayers: structure, preparation, and biomedical applications.

Saifullah B, Hussein MZ - Int J Nanomedicine (2015)

Bottom Line: Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science.These nanolayers have been widely applied in drug and gene delivery.The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes.

View Article: PubMed Central - PubMed

Affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Malaysia.

ABSTRACT
Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

No MeSH data available.


Related in: MedlinePlus

Possible chemiluminescence mechanism for the Co(II)-ethylenediaminetetraacetic acid (EDTA)-intercalated Mg/Al layered double hydroxide (LDH)-enhanced luminol–H2O2 system.Note: Reprinted from Zhang LJ, Chen YC, Zhang AM, Lu C. Highly selective sensing of hydrogen peroxide based on cobalt-ethylenediaminetetraacetate complex intercalated layered double hydroxide-enhanced luminol chemiluminescence. Sens Actuators B Chem. 2014;193:752–758, Copyright 2014, with permission from Elsevier.82
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f6-ijn-10-5609: Possible chemiluminescence mechanism for the Co(II)-ethylenediaminetetraacetic acid (EDTA)-intercalated Mg/Al layered double hydroxide (LDH)-enhanced luminol–H2O2 system.Note: Reprinted from Zhang LJ, Chen YC, Zhang AM, Lu C. Highly selective sensing of hydrogen peroxide based on cobalt-ethylenediaminetetraacetate complex intercalated layered double hydroxide-enhanced luminol chemiluminescence. Sens Actuators B Chem. 2014;193:752–758, Copyright 2014, with permission from Elsevier.82

Mentions: The likely mechanism of CL in the enhanced luminol–H2O2 system-based Co(II)-EDTA complex-intercalated LDHs is shown in Figure 6. There is an equilibrium between the Co(II) and EDTA, accompanied by a constant source of Co(II) ions to the luminol–H2O2 system. The Co(II) ions released then react with H O, producing lots of OH− and O2− ions, which can further react with luminol to emit light.82–84


Inorganic nanolayers: structure, preparation, and biomedical applications.

Saifullah B, Hussein MZ - Int J Nanomedicine (2015)

Possible chemiluminescence mechanism for the Co(II)-ethylenediaminetetraacetic acid (EDTA)-intercalated Mg/Al layered double hydroxide (LDH)-enhanced luminol–H2O2 system.Note: Reprinted from Zhang LJ, Chen YC, Zhang AM, Lu C. Highly selective sensing of hydrogen peroxide based on cobalt-ethylenediaminetetraacetate complex intercalated layered double hydroxide-enhanced luminol chemiluminescence. Sens Actuators B Chem. 2014;193:752–758, Copyright 2014, with permission from Elsevier.82
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562743&req=5

f6-ijn-10-5609: Possible chemiluminescence mechanism for the Co(II)-ethylenediaminetetraacetic acid (EDTA)-intercalated Mg/Al layered double hydroxide (LDH)-enhanced luminol–H2O2 system.Note: Reprinted from Zhang LJ, Chen YC, Zhang AM, Lu C. Highly selective sensing of hydrogen peroxide based on cobalt-ethylenediaminetetraacetate complex intercalated layered double hydroxide-enhanced luminol chemiluminescence. Sens Actuators B Chem. 2014;193:752–758, Copyright 2014, with permission from Elsevier.82
Mentions: The likely mechanism of CL in the enhanced luminol–H2O2 system-based Co(II)-EDTA complex-intercalated LDHs is shown in Figure 6. There is an equilibrium between the Co(II) and EDTA, accompanied by a constant source of Co(II) ions to the luminol–H2O2 system. The Co(II) ions released then react with H O, producing lots of OH− and O2− ions, which can further react with luminol to emit light.82–84

Bottom Line: Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science.These nanolayers have been widely applied in drug and gene delivery.The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes.

View Article: PubMed Central - PubMed

Affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Malaysia.

ABSTRACT
Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

No MeSH data available.


Related in: MedlinePlus