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Inorganic nanolayers: structure, preparation, and biomedical applications.

Saifullah B, Hussein MZ - Int J Nanomedicine (2015)

Bottom Line: Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science.These nanolayers have been widely applied in drug and gene delivery.The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes.

View Article: PubMed Central - PubMed

Affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Malaysia.

ABSTRACT
Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

No MeSH data available.


Structures of zinc hydroxide nitrate.Notes: (A) Side view and (B) top view. Reprinted from Arizaga GG, Satyanarayana KG, Wypych F. Layered hydroxide salts: synthesis, properties and potential applications. Solid State Ionics. 2007;178:1143–1162, Copyright 2007, with permission from Elsevier.11
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f4-ijn-10-5609: Structures of zinc hydroxide nitrate.Notes: (A) Side view and (B) top view. Reprinted from Arizaga GG, Satyanarayana KG, Wypych F. Layered hydroxide salts: synthesis, properties and potential applications. Solid State Ionics. 2007;178:1143–1162, Copyright 2007, with permission from Elsevier.11

Mentions: One way of modification of brucite-like structures is by induction of trivalent cations similar to LDHs. Another way of structure modification is by replacing the hydroxyl group (OH−1) with suitable anions or water molecules. These types of compounds are called layered hydroxides or LHS, with the general formula M2+ (OH−)2 × (Am−)x/m·nH2O, where M2+ is the metal cation (eg, Mg2+, Zn2+, Ca2+, Cd2+, Co2+, Ni2+, and Cu2+) and Am− is the counterion. In the layered hydroxide structure, additional anions must be located in the second coordination sphere.2,11,18Figure 4 shows the structure of LHS with both the side view (Figure 4A) and top view (Figure 4B).


Inorganic nanolayers: structure, preparation, and biomedical applications.

Saifullah B, Hussein MZ - Int J Nanomedicine (2015)

Structures of zinc hydroxide nitrate.Notes: (A) Side view and (B) top view. Reprinted from Arizaga GG, Satyanarayana KG, Wypych F. Layered hydroxide salts: synthesis, properties and potential applications. Solid State Ionics. 2007;178:1143–1162, Copyright 2007, with permission from Elsevier.11
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562743&req=5

f4-ijn-10-5609: Structures of zinc hydroxide nitrate.Notes: (A) Side view and (B) top view. Reprinted from Arizaga GG, Satyanarayana KG, Wypych F. Layered hydroxide salts: synthesis, properties and potential applications. Solid State Ionics. 2007;178:1143–1162, Copyright 2007, with permission from Elsevier.11
Mentions: One way of modification of brucite-like structures is by induction of trivalent cations similar to LDHs. Another way of structure modification is by replacing the hydroxyl group (OH−1) with suitable anions or water molecules. These types of compounds are called layered hydroxides or LHS, with the general formula M2+ (OH−)2 × (Am−)x/m·nH2O, where M2+ is the metal cation (eg, Mg2+, Zn2+, Ca2+, Cd2+, Co2+, Ni2+, and Cu2+) and Am− is the counterion. In the layered hydroxide structure, additional anions must be located in the second coordination sphere.2,11,18Figure 4 shows the structure of LHS with both the side view (Figure 4A) and top view (Figure 4B).

Bottom Line: Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science.These nanolayers have been widely applied in drug and gene delivery.The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes.

View Article: PubMed Central - PubMed

Affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Malaysia.

ABSTRACT
Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

No MeSH data available.