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Inorganic nanolayers: structure, preparation, and biomedical applications.

Saifullah B, Hussein MZ - Int J Nanomedicine (2015)

Bottom Line: Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science.These nanolayers have been widely applied in drug and gene delivery.The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes.

View Article: PubMed Central - PubMed

Affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Malaysia.

ABSTRACT
Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

No MeSH data available.


Release profiles of levodopa from the nanocomposite at pH 7.4 (A) and pH 4.8 (B).Notes: Inset shows the release profiles of levodopa from the nanocomposite at pH 4.8 from 0 to 2,000 minutes. Reproduced with permission from Kura AU, Hussein Al Ali SH, Hussein MZ, Fakurazi S, Arulselvan P. Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent. Int J Nanomedicine. 2013;8:1103–1110.178
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f11-ijn-10-5609: Release profiles of levodopa from the nanocomposite at pH 7.4 (A) and pH 4.8 (B).Notes: Inset shows the release profiles of levodopa from the nanocomposite at pH 4.8 from 0 to 2,000 minutes. Reproduced with permission from Kura AU, Hussein Al Ali SH, Hussein MZ, Fakurazi S, Arulselvan P. Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent. Int J Nanomedicine. 2013;8:1103–1110.178

Mentions: Kura et al intercalated the antiparkinsonian drug levodopa into LDHs and conducted in vitro release in PBS pH 7.4, wherein the drug release was found to be sustained until 8,500 minutes.178 The release of levodopa in PBS solution of pH 4.8 was completed in 2,400 minutes; this release was still considered sustained, but was relatively faster than the release at pH 7.4. Figure 11 shows the release of levodopa from LDHs in PBS of pH 7.4 and pH 4.8.178


Inorganic nanolayers: structure, preparation, and biomedical applications.

Saifullah B, Hussein MZ - Int J Nanomedicine (2015)

Release profiles of levodopa from the nanocomposite at pH 7.4 (A) and pH 4.8 (B).Notes: Inset shows the release profiles of levodopa from the nanocomposite at pH 4.8 from 0 to 2,000 minutes. Reproduced with permission from Kura AU, Hussein Al Ali SH, Hussein MZ, Fakurazi S, Arulselvan P. Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent. Int J Nanomedicine. 2013;8:1103–1110.178
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562743&req=5

f11-ijn-10-5609: Release profiles of levodopa from the nanocomposite at pH 7.4 (A) and pH 4.8 (B).Notes: Inset shows the release profiles of levodopa from the nanocomposite at pH 4.8 from 0 to 2,000 minutes. Reproduced with permission from Kura AU, Hussein Al Ali SH, Hussein MZ, Fakurazi S, Arulselvan P. Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent. Int J Nanomedicine. 2013;8:1103–1110.178
Mentions: Kura et al intercalated the antiparkinsonian drug levodopa into LDHs and conducted in vitro release in PBS pH 7.4, wherein the drug release was found to be sustained until 8,500 minutes.178 The release of levodopa in PBS solution of pH 4.8 was completed in 2,400 minutes; this release was still considered sustained, but was relatively faster than the release at pH 7.4. Figure 11 shows the release of levodopa from LDHs in PBS of pH 7.4 and pH 4.8.178

Bottom Line: Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science.These nanolayers have been widely applied in drug and gene delivery.The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes.

View Article: PubMed Central - PubMed

Affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Malaysia.

ABSTRACT
Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

No MeSH data available.