Limits...
Inorganic nanolayers: structure, preparation, and biomedical applications.

Saifullah B, Hussein MZ - Int J Nanomedicine (2015)

Bottom Line: Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science.These nanolayers have been widely applied in drug and gene delivery.The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes.

View Article: PubMed Central - PubMed

Affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Malaysia.

ABSTRACT
Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

No MeSH data available.


Confocal microscopic images of intracellular localization in NSC 34 cells.Notes: (A) 6.25 mg·mL−1 CO3 layered double hydroxide (LDH)–fluorescein isothiocyanate (FITC), incubated for 2.5 hours; (B) free 6.25 mg·mL−1 FITC anions incubated for 4 hours. Reproduced from Li SD, Li JH, Wang CL, et al. Cellular uptake and gene delivery using layered double hydroxide nanoparticles. J Mater Chem B. 2013:61–68, with permission of The Royal Society of Chemistry.162
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4562743&req=5

f10-ijn-10-5609: Confocal microscopic images of intracellular localization in NSC 34 cells.Notes: (A) 6.25 mg·mL−1 CO3 layered double hydroxide (LDH)–fluorescein isothiocyanate (FITC), incubated for 2.5 hours; (B) free 6.25 mg·mL−1 FITC anions incubated for 4 hours. Reproduced from Li SD, Li JH, Wang CL, et al. Cellular uptake and gene delivery using layered double hydroxide nanoparticles. J Mater Chem B. 2013:61–68, with permission of The Royal Society of Chemistry.162

Mentions: Figure 10 shows a confocal image depicting the cytoplasm in green fluorescence after incubation of 6.25 mg·mL−1 of CO3 LDH-FITC for 2.5 hours. Some of the particles have also entered the nucleus, as can be seen in green fluorescence in Figure 10A.162 The free FITC anions showed very weak green fluorescence at a much higher concentration of 6.25 mg·mL−1 compared to CO3 LDH-FITC. The lower free FITC cytoplasm entrance can be attributed to the mechanism of entrance: free FITC entrance takes place due to diffusion and not by endocytosis.162


Inorganic nanolayers: structure, preparation, and biomedical applications.

Saifullah B, Hussein MZ - Int J Nanomedicine (2015)

Confocal microscopic images of intracellular localization in NSC 34 cells.Notes: (A) 6.25 mg·mL−1 CO3 layered double hydroxide (LDH)–fluorescein isothiocyanate (FITC), incubated for 2.5 hours; (B) free 6.25 mg·mL−1 FITC anions incubated for 4 hours. Reproduced from Li SD, Li JH, Wang CL, et al. Cellular uptake and gene delivery using layered double hydroxide nanoparticles. J Mater Chem B. 2013:61–68, with permission of The Royal Society of Chemistry.162
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562743&req=5

f10-ijn-10-5609: Confocal microscopic images of intracellular localization in NSC 34 cells.Notes: (A) 6.25 mg·mL−1 CO3 layered double hydroxide (LDH)–fluorescein isothiocyanate (FITC), incubated for 2.5 hours; (B) free 6.25 mg·mL−1 FITC anions incubated for 4 hours. Reproduced from Li SD, Li JH, Wang CL, et al. Cellular uptake and gene delivery using layered double hydroxide nanoparticles. J Mater Chem B. 2013:61–68, with permission of The Royal Society of Chemistry.162
Mentions: Figure 10 shows a confocal image depicting the cytoplasm in green fluorescence after incubation of 6.25 mg·mL−1 of CO3 LDH-FITC for 2.5 hours. Some of the particles have also entered the nucleus, as can be seen in green fluorescence in Figure 10A.162 The free FITC anions showed very weak green fluorescence at a much higher concentration of 6.25 mg·mL−1 compared to CO3 LDH-FITC. The lower free FITC cytoplasm entrance can be attributed to the mechanism of entrance: free FITC entrance takes place due to diffusion and not by endocytosis.162

Bottom Line: Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science.These nanolayers have been widely applied in drug and gene delivery.The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes.

View Article: PubMed Central - PubMed

Affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Malaysia.

ABSTRACT
Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

No MeSH data available.