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Facial primer provides immediate and long-term improvements in mild-to-moderate facial hyperpigmentation and fine lines associated with photoaging.

Roberts WE, Jiang LI, Herndon JH - Clin Cosmet Investig Dermatol (2015)

Bottom Line: Photoaged skin results from various environmental factors, most importantly chronic sun exposure.Subject questionnaires showed that the product was highly rated at all visits.The facial primer was shown to be effective and well tolerated for immediate and long-term improvement in the appearance of mild-to-moderate hyperpigmentation and fine lines associated with photodamage when used over a 12-week period.

View Article: PubMed Central - PubMed

Affiliation: Generational and Cosmetic Dermatology, Rancho Mirage, CA, USA.

ABSTRACT

Background: Photoaged skin results from various environmental factors, most importantly chronic sun exposure. Dyschromia and fine lines/wrinkles are common clinical manifestations of photodamaged skin.

Purpose: This single-center clinical trial was conducted to assess the efficacy and tolerability of a new multifunctional facial primer (camouflage, broad-spectrum SPF 50, and a treatment for hyperpigmentation) when used by females with mild-to-moderate facial hyperpigmentation and fine lines due to photoaging over a course of 12 weeks.

Patients and methods: Subjects were provided test material (Even Up-Clinical Pigment Perfector) and supporting products to use on their face and neck. Products were used according to specific application instructions. Clinical grading for efficacy and tolerability assessments were performed by an expert grader at baseline, baseline (post-application primer), week 4, week 8, week 12, and week 12 (post-application primer). Standardized digital photographs were taken, and self-assessment questionnaires were conducted.

Results: Twenty-eight female subjects completed the 12-week trial. The facial primer improved scores for the appearance of hyperpigmentation and other photoaging parameters immediately after the first application. The treatment also showed a progressive improvement in the clinical assessment of hyperpigmentation and other photoaging parameters over the 12-week trial. These long-term benefits can be attributed to an improvement in the underlying skin condition. The facial primer was well tolerated. Subject questionnaires showed that the product was highly rated at all visits.

Conclusion: The facial primer was shown to be effective and well tolerated for immediate and long-term improvement in the appearance of mild-to-moderate hyperpigmentation and fine lines associated with photodamage when used over a 12-week period.

No MeSH data available.


Related in: MedlinePlus

Significant progressive improvements in the hyperpigmentation score with use of the facial primer over 12 weeks (no facial primer applied for these assessments).Note: All P≤0.001.
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f3-ccid-8-471: Significant progressive improvements in the hyperpigmentation score with use of the facial primer over 12 weeks (no facial primer applied for these assessments).Note: All P≤0.001.

Mentions: Similarly, statistically significant improvements were seen in other parameters of photoaging including skin tone, radiance, fine lines, skin smoothness, pore size, and overall appearance of the skin immediately following the first application which further improved after 12 weeks of product use (Figure 2). A statistical progressive improvement in hyperpigmentation scores upon assessment of bare skin (no primer applied) was seen at week 4, week 8, and week 12 indicating an improvement in skin quality with regular use of the products (Figure 3).


Facial primer provides immediate and long-term improvements in mild-to-moderate facial hyperpigmentation and fine lines associated with photoaging.

Roberts WE, Jiang LI, Herndon JH - Clin Cosmet Investig Dermatol (2015)

Significant progressive improvements in the hyperpigmentation score with use of the facial primer over 12 weeks (no facial primer applied for these assessments).Note: All P≤0.001.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562739&req=5

f3-ccid-8-471: Significant progressive improvements in the hyperpigmentation score with use of the facial primer over 12 weeks (no facial primer applied for these assessments).Note: All P≤0.001.
Mentions: Similarly, statistically significant improvements were seen in other parameters of photoaging including skin tone, radiance, fine lines, skin smoothness, pore size, and overall appearance of the skin immediately following the first application which further improved after 12 weeks of product use (Figure 2). A statistical progressive improvement in hyperpigmentation scores upon assessment of bare skin (no primer applied) was seen at week 4, week 8, and week 12 indicating an improvement in skin quality with regular use of the products (Figure 3).

Bottom Line: Photoaged skin results from various environmental factors, most importantly chronic sun exposure.Subject questionnaires showed that the product was highly rated at all visits.The facial primer was shown to be effective and well tolerated for immediate and long-term improvement in the appearance of mild-to-moderate hyperpigmentation and fine lines associated with photodamage when used over a 12-week period.

View Article: PubMed Central - PubMed

Affiliation: Generational and Cosmetic Dermatology, Rancho Mirage, CA, USA.

ABSTRACT

Background: Photoaged skin results from various environmental factors, most importantly chronic sun exposure. Dyschromia and fine lines/wrinkles are common clinical manifestations of photodamaged skin.

Purpose: This single-center clinical trial was conducted to assess the efficacy and tolerability of a new multifunctional facial primer (camouflage, broad-spectrum SPF 50, and a treatment for hyperpigmentation) when used by females with mild-to-moderate facial hyperpigmentation and fine lines due to photoaging over a course of 12 weeks.

Patients and methods: Subjects were provided test material (Even Up-Clinical Pigment Perfector) and supporting products to use on their face and neck. Products were used according to specific application instructions. Clinical grading for efficacy and tolerability assessments were performed by an expert grader at baseline, baseline (post-application primer), week 4, week 8, week 12, and week 12 (post-application primer). Standardized digital photographs were taken, and self-assessment questionnaires were conducted.

Results: Twenty-eight female subjects completed the 12-week trial. The facial primer improved scores for the appearance of hyperpigmentation and other photoaging parameters immediately after the first application. The treatment also showed a progressive improvement in the clinical assessment of hyperpigmentation and other photoaging parameters over the 12-week trial. These long-term benefits can be attributed to an improvement in the underlying skin condition. The facial primer was well tolerated. Subject questionnaires showed that the product was highly rated at all visits.

Conclusion: The facial primer was shown to be effective and well tolerated for immediate and long-term improvement in the appearance of mild-to-moderate hyperpigmentation and fine lines associated with photodamage when used over a 12-week period.

No MeSH data available.


Related in: MedlinePlus