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Facial primer provides immediate and long-term improvements in mild-to-moderate facial hyperpigmentation and fine lines associated with photoaging.

Roberts WE, Jiang LI, Herndon JH - Clin Cosmet Investig Dermatol (2015)

Bottom Line: Photoaged skin results from various environmental factors, most importantly chronic sun exposure.Subject questionnaires showed that the product was highly rated at all visits.The facial primer was shown to be effective and well tolerated for immediate and long-term improvement in the appearance of mild-to-moderate hyperpigmentation and fine lines associated with photodamage when used over a 12-week period.

View Article: PubMed Central - PubMed

Affiliation: Generational and Cosmetic Dermatology, Rancho Mirage, CA, USA.

ABSTRACT

Background: Photoaged skin results from various environmental factors, most importantly chronic sun exposure. Dyschromia and fine lines/wrinkles are common clinical manifestations of photodamaged skin.

Purpose: This single-center clinical trial was conducted to assess the efficacy and tolerability of a new multifunctional facial primer (camouflage, broad-spectrum SPF 50, and a treatment for hyperpigmentation) when used by females with mild-to-moderate facial hyperpigmentation and fine lines due to photoaging over a course of 12 weeks.

Patients and methods: Subjects were provided test material (Even Up-Clinical Pigment Perfector) and supporting products to use on their face and neck. Products were used according to specific application instructions. Clinical grading for efficacy and tolerability assessments were performed by an expert grader at baseline, baseline (post-application primer), week 4, week 8, week 12, and week 12 (post-application primer). Standardized digital photographs were taken, and self-assessment questionnaires were conducted.

Results: Twenty-eight female subjects completed the 12-week trial. The facial primer improved scores for the appearance of hyperpigmentation and other photoaging parameters immediately after the first application. The treatment also showed a progressive improvement in the clinical assessment of hyperpigmentation and other photoaging parameters over the 12-week trial. These long-term benefits can be attributed to an improvement in the underlying skin condition. The facial primer was well tolerated. Subject questionnaires showed that the product was highly rated at all visits.

Conclusion: The facial primer was shown to be effective and well tolerated for immediate and long-term improvement in the appearance of mild-to-moderate hyperpigmentation and fine lines associated with photodamage when used over a 12-week period.

No MeSH data available.


Related in: MedlinePlus

Facial primer provides immediate improvement in the hyperpigmentation score at first application of primer with greater improvement at week 12 compared to baseline.Note: *P≤0.001.
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f1-ccid-8-471: Facial primer provides immediate improvement in the hyperpigmentation score at first application of primer with greater improvement at week 12 compared to baseline.Note: *P≤0.001.

Mentions: Application of the facial primer produced a statistically significant 38.4% improvement in clinical grading scores for hyperpigmentation after first application when compared to bare skin condition at baseline. This immediate improvement is a result of covering up the imperfections and dark spots on the skin with micronized pigments. After 12 weeks of product use, a 43.9% improvement was seen compared to baseline (Figure 1). This additional improvement in clinical grading scores for hyperpigmentation at 12 weeks over the first application is the apparent result of the cumulative effect of key ingredients on the overall skin condition.


Facial primer provides immediate and long-term improvements in mild-to-moderate facial hyperpigmentation and fine lines associated with photoaging.

Roberts WE, Jiang LI, Herndon JH - Clin Cosmet Investig Dermatol (2015)

Facial primer provides immediate improvement in the hyperpigmentation score at first application of primer with greater improvement at week 12 compared to baseline.Note: *P≤0.001.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562739&req=5

f1-ccid-8-471: Facial primer provides immediate improvement in the hyperpigmentation score at first application of primer with greater improvement at week 12 compared to baseline.Note: *P≤0.001.
Mentions: Application of the facial primer produced a statistically significant 38.4% improvement in clinical grading scores for hyperpigmentation after first application when compared to bare skin condition at baseline. This immediate improvement is a result of covering up the imperfections and dark spots on the skin with micronized pigments. After 12 weeks of product use, a 43.9% improvement was seen compared to baseline (Figure 1). This additional improvement in clinical grading scores for hyperpigmentation at 12 weeks over the first application is the apparent result of the cumulative effect of key ingredients on the overall skin condition.

Bottom Line: Photoaged skin results from various environmental factors, most importantly chronic sun exposure.Subject questionnaires showed that the product was highly rated at all visits.The facial primer was shown to be effective and well tolerated for immediate and long-term improvement in the appearance of mild-to-moderate hyperpigmentation and fine lines associated with photodamage when used over a 12-week period.

View Article: PubMed Central - PubMed

Affiliation: Generational and Cosmetic Dermatology, Rancho Mirage, CA, USA.

ABSTRACT

Background: Photoaged skin results from various environmental factors, most importantly chronic sun exposure. Dyschromia and fine lines/wrinkles are common clinical manifestations of photodamaged skin.

Purpose: This single-center clinical trial was conducted to assess the efficacy and tolerability of a new multifunctional facial primer (camouflage, broad-spectrum SPF 50, and a treatment for hyperpigmentation) when used by females with mild-to-moderate facial hyperpigmentation and fine lines due to photoaging over a course of 12 weeks.

Patients and methods: Subjects were provided test material (Even Up-Clinical Pigment Perfector) and supporting products to use on their face and neck. Products were used according to specific application instructions. Clinical grading for efficacy and tolerability assessments were performed by an expert grader at baseline, baseline (post-application primer), week 4, week 8, week 12, and week 12 (post-application primer). Standardized digital photographs were taken, and self-assessment questionnaires were conducted.

Results: Twenty-eight female subjects completed the 12-week trial. The facial primer improved scores for the appearance of hyperpigmentation and other photoaging parameters immediately after the first application. The treatment also showed a progressive improvement in the clinical assessment of hyperpigmentation and other photoaging parameters over the 12-week trial. These long-term benefits can be attributed to an improvement in the underlying skin condition. The facial primer was well tolerated. Subject questionnaires showed that the product was highly rated at all visits.

Conclusion: The facial primer was shown to be effective and well tolerated for immediate and long-term improvement in the appearance of mild-to-moderate hyperpigmentation and fine lines associated with photodamage when used over a 12-week period.

No MeSH data available.


Related in: MedlinePlus