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Prevalence of quadriceps muscle weakness in patients with COPD and its association with disease severity.

Kharbanda S, Ramakrishna A, Krishnan S - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: The mean quadriceps muscle force value decreased with disease severity and this relation was found to be significant (P<0.01).Majority of the COPD patients were found to be suffering from quadriceps weakness, which was also present in significant proportions in subjects belonging to younger age groups and suffering from mild disease.These findings suggest need for early remedial measure to prevent occurrence of associated systemic diseases.

View Article: PubMed Central - PubMed

Affiliation: Kasturba Medical College, Manipal University, Mangaluru, Karnataka, India.

ABSTRACT

Introduction: COPD presents with an array of extra-pulmonary symptoms of which skeletal muscle dysfunction, particularly of the quadriceps, is well recognized. This contributes to impaired quality of life and increased health care utilization. Work on the quadriceps originated from the observation that a good proportion of COPD patients stop exercise due to the feeling of leg fatigue rather than breathlessness. This study was carried out with the aim of finding the prevalence of quadriceps weakness in a population set and correlate it with severity of COPD.

Methodology: This cross-sectional study was conducted in 75 subjects suffering from COPD aged 45 years or above. COPD severity in the subjects was graded based on the GOLD staging system. A digital hand held dynamometer (HHD) was used to measure quadriceps muscle strength. Descriptive statistics were done, and Pearson's Correlation Coefficient and ANOVA analysis was used for expressing the results.

Results: Ninety two percent of subjects were suffering from quadriceps muscle weakness. Quadriceps weakness was present in significantly high proportions even in those suffering from mild disease and belonging to a younger age group. The mean quadriceps muscle force value decreased with disease severity and this relation was found to be significant (P<0.01).

Conclusion: Majority of the COPD patients were found to be suffering from quadriceps weakness, which was also present in significant proportions in subjects belonging to younger age groups and suffering from mild disease. These findings indicate that onset of muscle weakness in COPD may precede the onset of symptoms. These findings suggest need for early remedial measure to prevent occurrence of associated systemic diseases.

No MeSH data available.


Related in: MedlinePlus

Scatter Plot showing the relation between body mass index (BMI) and the quadriceps muscle force of the participants (r=0.496).
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f3-copd-10-1727: Scatter Plot showing the relation between body mass index (BMI) and the quadriceps muscle force of the participants (r=0.496).

Mentions: We observed that the mean quadriceps force produced by the participants decreased as the grade of BMI (World Health Organization classification) decreased, but this relationship was found to be statistically insignificant (P≥0.05). However, we found a significant positive correlation between BMI value and quadriceps muscle force (r=0.496), implying that participants with higher BMI had higher quadriceps muscle force (P≤0.001, Figure 3).


Prevalence of quadriceps muscle weakness in patients with COPD and its association with disease severity.

Kharbanda S, Ramakrishna A, Krishnan S - Int J Chron Obstruct Pulmon Dis (2015)

Scatter Plot showing the relation between body mass index (BMI) and the quadriceps muscle force of the participants (r=0.496).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562732&req=5

f3-copd-10-1727: Scatter Plot showing the relation between body mass index (BMI) and the quadriceps muscle force of the participants (r=0.496).
Mentions: We observed that the mean quadriceps force produced by the participants decreased as the grade of BMI (World Health Organization classification) decreased, but this relationship was found to be statistically insignificant (P≥0.05). However, we found a significant positive correlation between BMI value and quadriceps muscle force (r=0.496), implying that participants with higher BMI had higher quadriceps muscle force (P≤0.001, Figure 3).

Bottom Line: The mean quadriceps muscle force value decreased with disease severity and this relation was found to be significant (P<0.01).Majority of the COPD patients were found to be suffering from quadriceps weakness, which was also present in significant proportions in subjects belonging to younger age groups and suffering from mild disease.These findings suggest need for early remedial measure to prevent occurrence of associated systemic diseases.

View Article: PubMed Central - PubMed

Affiliation: Kasturba Medical College, Manipal University, Mangaluru, Karnataka, India.

ABSTRACT

Introduction: COPD presents with an array of extra-pulmonary symptoms of which skeletal muscle dysfunction, particularly of the quadriceps, is well recognized. This contributes to impaired quality of life and increased health care utilization. Work on the quadriceps originated from the observation that a good proportion of COPD patients stop exercise due to the feeling of leg fatigue rather than breathlessness. This study was carried out with the aim of finding the prevalence of quadriceps weakness in a population set and correlate it with severity of COPD.

Methodology: This cross-sectional study was conducted in 75 subjects suffering from COPD aged 45 years or above. COPD severity in the subjects was graded based on the GOLD staging system. A digital hand held dynamometer (HHD) was used to measure quadriceps muscle strength. Descriptive statistics were done, and Pearson's Correlation Coefficient and ANOVA analysis was used for expressing the results.

Results: Ninety two percent of subjects were suffering from quadriceps muscle weakness. Quadriceps weakness was present in significantly high proportions even in those suffering from mild disease and belonging to a younger age group. The mean quadriceps muscle force value decreased with disease severity and this relation was found to be significant (P<0.01).

Conclusion: Majority of the COPD patients were found to be suffering from quadriceps weakness, which was also present in significant proportions in subjects belonging to younger age groups and suffering from mild disease. These findings indicate that onset of muscle weakness in COPD may precede the onset of symptoms. These findings suggest need for early remedial measure to prevent occurrence of associated systemic diseases.

No MeSH data available.


Related in: MedlinePlus