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Prevalence of quadriceps muscle weakness in patients with COPD and its association with disease severity.

Kharbanda S, Ramakrishna A, Krishnan S - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: The mean quadriceps muscle force value decreased with disease severity and this relation was found to be significant (P<0.01).Majority of the COPD patients were found to be suffering from quadriceps weakness, which was also present in significant proportions in subjects belonging to younger age groups and suffering from mild disease.These findings suggest need for early remedial measure to prevent occurrence of associated systemic diseases.

View Article: PubMed Central - PubMed

Affiliation: Kasturba Medical College, Manipal University, Mangaluru, Karnataka, India.

ABSTRACT

Introduction: COPD presents with an array of extra-pulmonary symptoms of which skeletal muscle dysfunction, particularly of the quadriceps, is well recognized. This contributes to impaired quality of life and increased health care utilization. Work on the quadriceps originated from the observation that a good proportion of COPD patients stop exercise due to the feeling of leg fatigue rather than breathlessness. This study was carried out with the aim of finding the prevalence of quadriceps weakness in a population set and correlate it with severity of COPD.

Methodology: This cross-sectional study was conducted in 75 subjects suffering from COPD aged 45 years or above. COPD severity in the subjects was graded based on the GOLD staging system. A digital hand held dynamometer (HHD) was used to measure quadriceps muscle strength. Descriptive statistics were done, and Pearson's Correlation Coefficient and ANOVA analysis was used for expressing the results.

Results: Ninety two percent of subjects were suffering from quadriceps muscle weakness. Quadriceps weakness was present in significantly high proportions even in those suffering from mild disease and belonging to a younger age group. The mean quadriceps muscle force value decreased with disease severity and this relation was found to be significant (P<0.01).

Conclusion: Majority of the COPD patients were found to be suffering from quadriceps weakness, which was also present in significant proportions in subjects belonging to younger age groups and suffering from mild disease. These findings indicate that onset of muscle weakness in COPD may precede the onset of symptoms. These findings suggest need for early remedial measure to prevent occurrence of associated systemic diseases.

No MeSH data available.


Related in: MedlinePlus

Distribution of subjects according to COPD grade (GOLD classification).Abbreviations: COPD, chronic obstructive pulmonary disease; GOLD, Global Initiative for Chronic Obstructive Lung Disease.
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f1-copd-10-1727: Distribution of subjects according to COPD grade (GOLD classification).Abbreviations: COPD, chronic obstructive pulmonary disease; GOLD, Global Initiative for Chronic Obstructive Lung Disease.

Mentions: The overall mean body weight and body mass index (BMI) was 57.4 kg and 22.3 kg/m2, with males having a higher mean in both categories. As expected, the right limb was dominant in 93.3% of the participants. The majority (30.7%) of the participants suffered from severe COPD and were classified as having stage 3 COPD as per the GOLD criteria (Figure 1).


Prevalence of quadriceps muscle weakness in patients with COPD and its association with disease severity.

Kharbanda S, Ramakrishna A, Krishnan S - Int J Chron Obstruct Pulmon Dis (2015)

Distribution of subjects according to COPD grade (GOLD classification).Abbreviations: COPD, chronic obstructive pulmonary disease; GOLD, Global Initiative for Chronic Obstructive Lung Disease.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562732&req=5

f1-copd-10-1727: Distribution of subjects according to COPD grade (GOLD classification).Abbreviations: COPD, chronic obstructive pulmonary disease; GOLD, Global Initiative for Chronic Obstructive Lung Disease.
Mentions: The overall mean body weight and body mass index (BMI) was 57.4 kg and 22.3 kg/m2, with males having a higher mean in both categories. As expected, the right limb was dominant in 93.3% of the participants. The majority (30.7%) of the participants suffered from severe COPD and were classified as having stage 3 COPD as per the GOLD criteria (Figure 1).

Bottom Line: The mean quadriceps muscle force value decreased with disease severity and this relation was found to be significant (P<0.01).Majority of the COPD patients were found to be suffering from quadriceps weakness, which was also present in significant proportions in subjects belonging to younger age groups and suffering from mild disease.These findings suggest need for early remedial measure to prevent occurrence of associated systemic diseases.

View Article: PubMed Central - PubMed

Affiliation: Kasturba Medical College, Manipal University, Mangaluru, Karnataka, India.

ABSTRACT

Introduction: COPD presents with an array of extra-pulmonary symptoms of which skeletal muscle dysfunction, particularly of the quadriceps, is well recognized. This contributes to impaired quality of life and increased health care utilization. Work on the quadriceps originated from the observation that a good proportion of COPD patients stop exercise due to the feeling of leg fatigue rather than breathlessness. This study was carried out with the aim of finding the prevalence of quadriceps weakness in a population set and correlate it with severity of COPD.

Methodology: This cross-sectional study was conducted in 75 subjects suffering from COPD aged 45 years or above. COPD severity in the subjects was graded based on the GOLD staging system. A digital hand held dynamometer (HHD) was used to measure quadriceps muscle strength. Descriptive statistics were done, and Pearson's Correlation Coefficient and ANOVA analysis was used for expressing the results.

Results: Ninety two percent of subjects were suffering from quadriceps muscle weakness. Quadriceps weakness was present in significantly high proportions even in those suffering from mild disease and belonging to a younger age group. The mean quadriceps muscle force value decreased with disease severity and this relation was found to be significant (P<0.01).

Conclusion: Majority of the COPD patients were found to be suffering from quadriceps weakness, which was also present in significant proportions in subjects belonging to younger age groups and suffering from mild disease. These findings indicate that onset of muscle weakness in COPD may precede the onset of symptoms. These findings suggest need for early remedial measure to prevent occurrence of associated systemic diseases.

No MeSH data available.


Related in: MedlinePlus