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Low bone mineral density in COPD patients with osteoporosis is related to low daily physical activity and high COPD assessment test scores.

Liu WT, Kuo HP, Liao TH, Chiang LL, Chen LF, Hsu MF, Chuang HC, Lee KY, Huang CD, Ho SC - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: OP was defined as a T-score (standard deviations from a young, sex-specific reference mean BMD) less than or equal to -2.5 SD for the lumbar spine, total hip, and femoral neck.DPA was significantly positively correlated with (lumbar spine, total hip, and femoral neck) BMD (r=0.399, 0.602, 0.438, respectively, all P<0.05) and T-score (r=0.471, 0.531, 0.459, respectively, all P<0.05), whereas CAT scores were significantly negatively correlated with (total hip and femoral neck) BMD (r=-0.412, -0.552, respectively, P<0.05) and (lumbar spine, total hip, and femoral neck) T-score (r=-0.389, -0.429, -0.543, respectively, P<0.05).Our results show no significant difference in desaturation index, low SpO2, and inflammatory markers (IL-6, TNF-α, IL-8/CXCL8, CRP, and 8-isoprostane) between the two groups.

View Article: PubMed Central - PubMed

Affiliation: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan ; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.

ABSTRACT
COPD patients have an increased prevalence of osteoporosis (OP) compared with healthy people. Physical inactivity in COPD patients is a crucial risk factor for OP; the COPD assessment test (CAT) is the newest assessment tool for the health status and daily activities of COPD patients. This study investigated the relationship among daily physical activity (DPA), CAT scores, and bone mineral density (BMD) in COPD patients with or without OP. This study included 30 participants. Ambulatory DPA was measured using actigraphy and oxygen saturation by using a pulse oximeter. BMD was measured using dual-energy X-ray absorptiometry. OP was defined as a T-score (standard deviations from a young, sex-specific reference mean BMD) less than or equal to -2.5 SD for the lumbar spine, total hip, and femoral neck. We quantified oxygen desaturation during DPA by using a desaturation index and recorded all DPA, except during sleep. COPD patients with OP had lower DPA and higher CAT scores than those of patients without OP. DPA was significantly positively correlated with (lumbar spine, total hip, and femoral neck) BMD (r=0.399, 0.602, 0.438, respectively, all P<0.05) and T-score (r=0.471, 0.531, 0.459, respectively, all P<0.05), whereas CAT scores were significantly negatively correlated with (total hip and femoral neck) BMD (r=-0.412, -0.552, respectively, P<0.05) and (lumbar spine, total hip, and femoral neck) T-score (r=-0.389, -0.429, -0.543, respectively, P<0.05). Low femoral neck BMD in COPD patients was related to high CAT scores. Our results show no significant difference in desaturation index, low SpO2, and inflammatory markers (IL-6, TNF-α, IL-8/CXCL8, CRP, and 8-isoprostane) between the two groups. Chest physicians should be aware that COPD patients with OP have low DPA and high CAT scores.

No MeSH data available.


Related in: MedlinePlus

Comparison between OP and without OP.Notes: (A) Daily physical activity, desaturation index, and low pulse oxygen saturation in COPD patients without and with OP; (B) serum TNF-α, IL-6, CRP, and 8-isoprostane levels in COPD patients without and with OP; *P<0.05; circles, without OP; squares, OP.Abbreviations: OP, osteoporosis; cts·min−1, counts per minute.
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f1-copd-10-1737: Comparison between OP and without OP.Notes: (A) Daily physical activity, desaturation index, and low pulse oxygen saturation in COPD patients without and with OP; (B) serum TNF-α, IL-6, CRP, and 8-isoprostane levels in COPD patients without and with OP; *P<0.05; circles, without OP; squares, OP.Abbreviations: OP, osteoporosis; cts·min−1, counts per minute.

Mentions: Figure 1A shows that COPD patients with OP had significantly lower DPA (P=0.0193) than that of those without OP; however, no significant differences were observed in DSI and low SpO2 (P=0.1330 and 0.8946) between the two groups. Figure 1B indicates that TNF-α (1.35±0.33 vs 1.10±0.12, P>0.05), IL-6 (1.77±0.34 vs 1.55±0.26, P>0.05), CRP (3.72±1.55 vs 5.49±1.63, P>0.05), and 8-isoprostane (12.25±1.08 vs 13.04±1.06, P>0.05) were not significantly different between COPD patients without and with OP.


Low bone mineral density in COPD patients with osteoporosis is related to low daily physical activity and high COPD assessment test scores.

Liu WT, Kuo HP, Liao TH, Chiang LL, Chen LF, Hsu MF, Chuang HC, Lee KY, Huang CD, Ho SC - Int J Chron Obstruct Pulmon Dis (2015)

Comparison between OP and without OP.Notes: (A) Daily physical activity, desaturation index, and low pulse oxygen saturation in COPD patients without and with OP; (B) serum TNF-α, IL-6, CRP, and 8-isoprostane levels in COPD patients without and with OP; *P<0.05; circles, without OP; squares, OP.Abbreviations: OP, osteoporosis; cts·min−1, counts per minute.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562728&req=5

f1-copd-10-1737: Comparison between OP and without OP.Notes: (A) Daily physical activity, desaturation index, and low pulse oxygen saturation in COPD patients without and with OP; (B) serum TNF-α, IL-6, CRP, and 8-isoprostane levels in COPD patients without and with OP; *P<0.05; circles, without OP; squares, OP.Abbreviations: OP, osteoporosis; cts·min−1, counts per minute.
Mentions: Figure 1A shows that COPD patients with OP had significantly lower DPA (P=0.0193) than that of those without OP; however, no significant differences were observed in DSI and low SpO2 (P=0.1330 and 0.8946) between the two groups. Figure 1B indicates that TNF-α (1.35±0.33 vs 1.10±0.12, P>0.05), IL-6 (1.77±0.34 vs 1.55±0.26, P>0.05), CRP (3.72±1.55 vs 5.49±1.63, P>0.05), and 8-isoprostane (12.25±1.08 vs 13.04±1.06, P>0.05) were not significantly different between COPD patients without and with OP.

Bottom Line: OP was defined as a T-score (standard deviations from a young, sex-specific reference mean BMD) less than or equal to -2.5 SD for the lumbar spine, total hip, and femoral neck.DPA was significantly positively correlated with (lumbar spine, total hip, and femoral neck) BMD (r=0.399, 0.602, 0.438, respectively, all P<0.05) and T-score (r=0.471, 0.531, 0.459, respectively, all P<0.05), whereas CAT scores were significantly negatively correlated with (total hip and femoral neck) BMD (r=-0.412, -0.552, respectively, P<0.05) and (lumbar spine, total hip, and femoral neck) T-score (r=-0.389, -0.429, -0.543, respectively, P<0.05).Our results show no significant difference in desaturation index, low SpO2, and inflammatory markers (IL-6, TNF-α, IL-8/CXCL8, CRP, and 8-isoprostane) between the two groups.

View Article: PubMed Central - PubMed

Affiliation: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan ; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.

ABSTRACT
COPD patients have an increased prevalence of osteoporosis (OP) compared with healthy people. Physical inactivity in COPD patients is a crucial risk factor for OP; the COPD assessment test (CAT) is the newest assessment tool for the health status and daily activities of COPD patients. This study investigated the relationship among daily physical activity (DPA), CAT scores, and bone mineral density (BMD) in COPD patients with or without OP. This study included 30 participants. Ambulatory DPA was measured using actigraphy and oxygen saturation by using a pulse oximeter. BMD was measured using dual-energy X-ray absorptiometry. OP was defined as a T-score (standard deviations from a young, sex-specific reference mean BMD) less than or equal to -2.5 SD for the lumbar spine, total hip, and femoral neck. We quantified oxygen desaturation during DPA by using a desaturation index and recorded all DPA, except during sleep. COPD patients with OP had lower DPA and higher CAT scores than those of patients without OP. DPA was significantly positively correlated with (lumbar spine, total hip, and femoral neck) BMD (r=0.399, 0.602, 0.438, respectively, all P<0.05) and T-score (r=0.471, 0.531, 0.459, respectively, all P<0.05), whereas CAT scores were significantly negatively correlated with (total hip and femoral neck) BMD (r=-0.412, -0.552, respectively, P<0.05) and (lumbar spine, total hip, and femoral neck) T-score (r=-0.389, -0.429, -0.543, respectively, P<0.05). Low femoral neck BMD in COPD patients was related to high CAT scores. Our results show no significant difference in desaturation index, low SpO2, and inflammatory markers (IL-6, TNF-α, IL-8/CXCL8, CRP, and 8-isoprostane) between the two groups. Chest physicians should be aware that COPD patients with OP have low DPA and high CAT scores.

No MeSH data available.


Related in: MedlinePlus