Limits...
Extracellular Vesicles: Role in Inflammatory Responses and Potential Uses in Vaccination in Cancer and Infectious Diseases.

Campos JH, Soares RP, Ribeiro K, Andrade AC, Batista WL, Torrecilhas AC - J Immunol Res (2015)

Bottom Line: Almost all cells and organisms release membrane structures containing proteins, lipids, and nucleic acids called extracellular vesicles (EVs), which have a wide range of functions concerning intercellular communication and signaling events.Recently, the characterization and understanding of their biological role have become a main research area due to their potential role in vaccination, as biomarkers antigens, early diagnostic tools, and therapeutic applications.Here, we will overview the recent advances and studies of Evs shed by tumor cells, bacteria, parasites, and fungi, focusing on their inflammatory role and their potential use in vaccination and diagnostic of cancer and infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Biológicas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, 09913-030 São Paulo, SP, Brazil.

ABSTRACT
Almost all cells and organisms release membrane structures containing proteins, lipids, and nucleic acids called extracellular vesicles (EVs), which have a wide range of functions concerning intercellular communication and signaling events. Recently, the characterization and understanding of their biological role have become a main research area due to their potential role in vaccination, as biomarkers antigens, early diagnostic tools, and therapeutic applications. Here, we will overview the recent advances and studies of Evs shed by tumor cells, bacteria, parasites, and fungi, focusing on their inflammatory role and their potential use in vaccination and diagnostic of cancer and infectious diseases.

No MeSH data available.


Related in: MedlinePlus

Schematic review of the origin function and markers (molecules to delivery) of EVs normal and tumor cells, parasites, fungi, and bacteria.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4562184&req=5

fig1: Schematic review of the origin function and markers (molecules to delivery) of EVs normal and tumor cells, parasites, fungi, and bacteria.

Mentions: Extracellular vesicles (EVs) are particles of 20 nm up to 5 μm in diameter composed of proteins, nucleic acid, and lipids that are found in body fluids such as plasma, serum, saliva, urine, breast milk, ascites, and cerebrospinal fluids [1]. These particles are involved in intercellular communication, modulating a wide range of signaling events during innate and acquired immune responses (Figure 1 and Table 1) [2–4]. EVs are secreted during health conditions or upon inflammation during the course of diseases by all mammalian cells types [2, 3, 5].


Extracellular Vesicles: Role in Inflammatory Responses and Potential Uses in Vaccination in Cancer and Infectious Diseases.

Campos JH, Soares RP, Ribeiro K, Andrade AC, Batista WL, Torrecilhas AC - J Immunol Res (2015)

Schematic review of the origin function and markers (molecules to delivery) of EVs normal and tumor cells, parasites, fungi, and bacteria.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4562184&req=5

fig1: Schematic review of the origin function and markers (molecules to delivery) of EVs normal and tumor cells, parasites, fungi, and bacteria.
Mentions: Extracellular vesicles (EVs) are particles of 20 nm up to 5 μm in diameter composed of proteins, nucleic acid, and lipids that are found in body fluids such as plasma, serum, saliva, urine, breast milk, ascites, and cerebrospinal fluids [1]. These particles are involved in intercellular communication, modulating a wide range of signaling events during innate and acquired immune responses (Figure 1 and Table 1) [2–4]. EVs are secreted during health conditions or upon inflammation during the course of diseases by all mammalian cells types [2, 3, 5].

Bottom Line: Almost all cells and organisms release membrane structures containing proteins, lipids, and nucleic acids called extracellular vesicles (EVs), which have a wide range of functions concerning intercellular communication and signaling events.Recently, the characterization and understanding of their biological role have become a main research area due to their potential role in vaccination, as biomarkers antigens, early diagnostic tools, and therapeutic applications.Here, we will overview the recent advances and studies of Evs shed by tumor cells, bacteria, parasites, and fungi, focusing on their inflammatory role and their potential use in vaccination and diagnostic of cancer and infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Biológicas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, 09913-030 São Paulo, SP, Brazil.

ABSTRACT
Almost all cells and organisms release membrane structures containing proteins, lipids, and nucleic acids called extracellular vesicles (EVs), which have a wide range of functions concerning intercellular communication and signaling events. Recently, the characterization and understanding of their biological role have become a main research area due to their potential role in vaccination, as biomarkers antigens, early diagnostic tools, and therapeutic applications. Here, we will overview the recent advances and studies of Evs shed by tumor cells, bacteria, parasites, and fungi, focusing on their inflammatory role and their potential use in vaccination and diagnostic of cancer and infectious diseases.

No MeSH data available.


Related in: MedlinePlus