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Tranexamic acid reduces blood loss and need of blood transfusion in total knee arthroplasty: A prospective, randomized, double-blind study in Indian population.

Shinde A, Sobti A, Maniar S, Mishra A, Gite R, Shetty V - Asian J Transfus Sci (2015 Jul-Dec)

Bottom Line: The mean blood loss in the TEA unilateral group was 295 mL ± 218 mL and in the placebo group was 482 mL ± 186 mL (P < 0.005).In the bilateral TEA group, the mean blood loss was 596 mL ± 235 mL and in the placebo group was 1349 mL ± 41 mL (P < 0.005).The number of patients requiring blood transfusion reduced substantially.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India.

ABSTRACT

Introduction: For quite a few years, tranexamic acid (TEA) has been used during total knee arthroplasty (TKA) to reduce blood loss. However, no consensus exits regarding its timing and doses.

Materials and methods: We conducted a prospective, randomized double-blinded study of 56 patients in the Indian population undergoing TKA from 2011 to 2012. A dose of 10 mg/kg body weight of TEA (three doses) was given in one group and normal saline was administered in the other.

Results: The mean blood loss in the TEA unilateral group was 295 mL ± 218 mL and in the placebo group was 482 mL ± 186 mL (P < 0.005). In the bilateral TEA group, the mean blood loss was 596 mL ± 235 mL and in the placebo group was 1349 mL ± 41 mL (P < 0.005).

Conclusion: The number of patients requiring blood transfusion reduced substantially. There was no increase in the risk of deep vein thrombosis (DVT) and pulmonary embolism. TEA reduces intraoperative and postoperative blood loss and thus reduces the need of allogenic blood transfusion.

No MeSH data available.


Related in: MedlinePlus

Fall in the level of hemoglobin, X-axis: Value of Hb in gm%, Y-axis: Day of stay in hospital
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Figure 1: Fall in the level of hemoglobin, X-axis: Value of Hb in gm%, Y-axis: Day of stay in hospital

Mentions: The mean hemoglobin decrease 24 h postoperatively was lower (P < 0.005) in patients receiving TEA unilateral (1 ± 0.02 g/dL) than in the control unilateral group (2.15 ± 0.42 g/dL). The mean hemoglobin decrease 24 h postoperatively was lower (P < 0.005) in patients in the TEA (2 ± 0.16 g/dL) bilateral group than in the control bilateral group (3.89 ± 0.09 g/dL) [Figure 1].


Tranexamic acid reduces blood loss and need of blood transfusion in total knee arthroplasty: A prospective, randomized, double-blind study in Indian population.

Shinde A, Sobti A, Maniar S, Mishra A, Gite R, Shetty V - Asian J Transfus Sci (2015 Jul-Dec)

Fall in the level of hemoglobin, X-axis: Value of Hb in gm%, Y-axis: Day of stay in hospital
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4562139&req=5

Figure 1: Fall in the level of hemoglobin, X-axis: Value of Hb in gm%, Y-axis: Day of stay in hospital
Mentions: The mean hemoglobin decrease 24 h postoperatively was lower (P < 0.005) in patients receiving TEA unilateral (1 ± 0.02 g/dL) than in the control unilateral group (2.15 ± 0.42 g/dL). The mean hemoglobin decrease 24 h postoperatively was lower (P < 0.005) in patients in the TEA (2 ± 0.16 g/dL) bilateral group than in the control bilateral group (3.89 ± 0.09 g/dL) [Figure 1].

Bottom Line: The mean blood loss in the TEA unilateral group was 295 mL ± 218 mL and in the placebo group was 482 mL ± 186 mL (P < 0.005).In the bilateral TEA group, the mean blood loss was 596 mL ± 235 mL and in the placebo group was 1349 mL ± 41 mL (P < 0.005).The number of patients requiring blood transfusion reduced substantially.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India.

ABSTRACT

Introduction: For quite a few years, tranexamic acid (TEA) has been used during total knee arthroplasty (TKA) to reduce blood loss. However, no consensus exits regarding its timing and doses.

Materials and methods: We conducted a prospective, randomized double-blinded study of 56 patients in the Indian population undergoing TKA from 2011 to 2012. A dose of 10 mg/kg body weight of TEA (three doses) was given in one group and normal saline was administered in the other.

Results: The mean blood loss in the TEA unilateral group was 295 mL ± 218 mL and in the placebo group was 482 mL ± 186 mL (P < 0.005). In the bilateral TEA group, the mean blood loss was 596 mL ± 235 mL and in the placebo group was 1349 mL ± 41 mL (P < 0.005).

Conclusion: The number of patients requiring blood transfusion reduced substantially. There was no increase in the risk of deep vein thrombosis (DVT) and pulmonary embolism. TEA reduces intraoperative and postoperative blood loss and thus reduces the need of allogenic blood transfusion.

No MeSH data available.


Related in: MedlinePlus