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Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis.

Moncada D, Ballarini F, Viola H - Neural Plast. (2015)

Bottom Line: BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins.In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory.We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Biologia Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina.

ABSTRACT
Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced in the network. The synaptic tagging and capture theory provided a strong framework to explain synaptic specificity and persistence of electrophysiological induced plastic changes. Ten years later, the behavioral tagging hypothesis (BT) made use of the same argument, applying it to learning and memory models. The hypothesis postulates that the formation of lasting memories relies on at least two processes: the setting of a learning tag and the synthesis of plasticity related proteins, which once captured at tagged sites allow memory consolidation. BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins. In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory. We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

No MeSH data available.


Related in: MedlinePlus

Behavioral tagging in LTM-persistence. In the life of a memory could be at least two rounds of tags. (a) At the time of a weak training, a learning tag is set (dashed circle). However, as there are no PRPs synthesis, consolidation does not occur. (b) A strong training per-se triggers two processes: the setting of a learning tag and the synthesis of PRPs (red circle). The capture of these products by the learning tags led the formation of a LTM (usually tested 1 day after training). Moreover, we postulated that the strong training also induces in a delay fashion a second round of tagging (maintenance tag) emerging at 11 h after training (dashed-dotted circle). (c) A stronger training (persistence strong training), will allow memory to persist at least for a week (L-LTM). This persistent expression of memory could depend on the capability of a late established maintenance tag (dashed-dotted circle) to use/capture PRPs (red circle) derived of a late wave of protein synthesis. It was reported that this very strong training session induces a delay window of protein synthesis on which its memory persistence relies. Also, in the case of a strong training session (which induce only LTM), PRPs provided by a pharmacological intervention or by a behavioral experience can promote L-LTM if they are available around the time of the maintenance tag.
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fig5: Behavioral tagging in LTM-persistence. In the life of a memory could be at least two rounds of tags. (a) At the time of a weak training, a learning tag is set (dashed circle). However, as there are no PRPs synthesis, consolidation does not occur. (b) A strong training per-se triggers two processes: the setting of a learning tag and the synthesis of PRPs (red circle). The capture of these products by the learning tags led the formation of a LTM (usually tested 1 day after training). Moreover, we postulated that the strong training also induces in a delay fashion a second round of tagging (maintenance tag) emerging at 11 h after training (dashed-dotted circle). (c) A stronger training (persistence strong training), will allow memory to persist at least for a week (L-LTM). This persistent expression of memory could depend on the capability of a late established maintenance tag (dashed-dotted circle) to use/capture PRPs (red circle) derived of a late wave of protein synthesis. It was reported that this very strong training session induces a delay window of protein synthesis on which its memory persistence relies. Also, in the case of a strong training session (which induce only LTM), PRPs provided by a pharmacological intervention or by a behavioral experience can promote L-LTM if they are available around the time of the maintenance tag.

Mentions: It is well known that a late BDNF (brain-derived neurotrophic factor) and protein synthesis dependent phase of memory formation, occurring around 12 h after strong IA training in the dorsal hippocampus, is required for memory persistence [6, 119, 120]. Expanding the postulates of STC hypothesis and its BT translation, we further think that beside the tagging process displayed in memory consolidation, some “retagging” of specific sites would occur late after training enabling memory persistence through the capture of these late PRPs. So, we propose that a learning experience able to induce a LTM could signal at least two marks separated in time (immediate after IA training and 11-12 h later), which capture PRPs to allow, in first instance, the consolidation of a LTM and then to grant its persistence for longer periods of time (Figure 5).


Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis.

Moncada D, Ballarini F, Viola H - Neural Plast. (2015)

Behavioral tagging in LTM-persistence. In the life of a memory could be at least two rounds of tags. (a) At the time of a weak training, a learning tag is set (dashed circle). However, as there are no PRPs synthesis, consolidation does not occur. (b) A strong training per-se triggers two processes: the setting of a learning tag and the synthesis of PRPs (red circle). The capture of these products by the learning tags led the formation of a LTM (usually tested 1 day after training). Moreover, we postulated that the strong training also induces in a delay fashion a second round of tagging (maintenance tag) emerging at 11 h after training (dashed-dotted circle). (c) A stronger training (persistence strong training), will allow memory to persist at least for a week (L-LTM). This persistent expression of memory could depend on the capability of a late established maintenance tag (dashed-dotted circle) to use/capture PRPs (red circle) derived of a late wave of protein synthesis. It was reported that this very strong training session induces a delay window of protein synthesis on which its memory persistence relies. Also, in the case of a strong training session (which induce only LTM), PRPs provided by a pharmacological intervention or by a behavioral experience can promote L-LTM if they are available around the time of the maintenance tag.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4562088&req=5

fig5: Behavioral tagging in LTM-persistence. In the life of a memory could be at least two rounds of tags. (a) At the time of a weak training, a learning tag is set (dashed circle). However, as there are no PRPs synthesis, consolidation does not occur. (b) A strong training per-se triggers two processes: the setting of a learning tag and the synthesis of PRPs (red circle). The capture of these products by the learning tags led the formation of a LTM (usually tested 1 day after training). Moreover, we postulated that the strong training also induces in a delay fashion a second round of tagging (maintenance tag) emerging at 11 h after training (dashed-dotted circle). (c) A stronger training (persistence strong training), will allow memory to persist at least for a week (L-LTM). This persistent expression of memory could depend on the capability of a late established maintenance tag (dashed-dotted circle) to use/capture PRPs (red circle) derived of a late wave of protein synthesis. It was reported that this very strong training session induces a delay window of protein synthesis on which its memory persistence relies. Also, in the case of a strong training session (which induce only LTM), PRPs provided by a pharmacological intervention or by a behavioral experience can promote L-LTM if they are available around the time of the maintenance tag.
Mentions: It is well known that a late BDNF (brain-derived neurotrophic factor) and protein synthesis dependent phase of memory formation, occurring around 12 h after strong IA training in the dorsal hippocampus, is required for memory persistence [6, 119, 120]. Expanding the postulates of STC hypothesis and its BT translation, we further think that beside the tagging process displayed in memory consolidation, some “retagging” of specific sites would occur late after training enabling memory persistence through the capture of these late PRPs. So, we propose that a learning experience able to induce a LTM could signal at least two marks separated in time (immediate after IA training and 11-12 h later), which capture PRPs to allow, in first instance, the consolidation of a LTM and then to grant its persistence for longer periods of time (Figure 5).

Bottom Line: BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins.In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory.We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Biologia Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina.

ABSTRACT
Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced in the network. The synaptic tagging and capture theory provided a strong framework to explain synaptic specificity and persistence of electrophysiological induced plastic changes. Ten years later, the behavioral tagging hypothesis (BT) made use of the same argument, applying it to learning and memory models. The hypothesis postulates that the formation of lasting memories relies on at least two processes: the setting of a learning tag and the synthesis of plasticity related proteins, which once captured at tagged sites allow memory consolidation. BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins. In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory. We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

No MeSH data available.


Related in: MedlinePlus