Limits...
Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis.

Moncada D, Ballarini F, Viola H - Neural Plast. (2015)

Bottom Line: BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins.In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory.We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Biologia Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina.

ABSTRACT
Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced in the network. The synaptic tagging and capture theory provided a strong framework to explain synaptic specificity and persistence of electrophysiological induced plastic changes. Ten years later, the behavioral tagging hypothesis (BT) made use of the same argument, applying it to learning and memory models. The hypothesis postulates that the formation of lasting memories relies on at least two processes: the setting of a learning tag and the synthesis of plasticity related proteins, which once captured at tagged sites allow memory consolidation. BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins. In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory. We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

No MeSH data available.


Related in: MedlinePlus

Competence for PRPs in LTM formation. A strong training not only triggers the synthesis of PRPs (red circle) but also induces its learning tag (dashed-dotted circle). Weak training experienced close to the strong one only set its corresponding learning tag (dashed-circle). So, these different types of tags could compete inside a cell to capture the PRPs that are available around them. If the amount of proteins is limited it was observed that one LTM is promoted and the other one is impaired. This process should be accomplished in a subset of cells which were activated by both training experiences.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4562088&req=5

fig3: Competence for PRPs in LTM formation. A strong training not only triggers the synthesis of PRPs (red circle) but also induces its learning tag (dashed-dotted circle). Weak training experienced close to the strong one only set its corresponding learning tag (dashed-circle). So, these different types of tags could compete inside a cell to capture the PRPs that are available around them. If the amount of proteins is limited it was observed that one LTM is promoted and the other one is impaired. This process should be accomplished in a subset of cells which were activated by both training experiences.

Mentions: We hypothesize that if different learning experiences are being consolidated into LTM, intracellular competition for PRPs among their respective learning tags will define which of the memory traces becomes stabilized in the neuronal network. Based on the protocols of the first BT experiments [32], this has been tested by combining wIA and novel OF, two tasks that are dependent on hippocampus processing. If rats are sequentially exposed to two different memory tasks under limited protein synthesis, OF exploration promotes IA-LTM formation from a wIA training session and this occurs in detriment of the OF's LTM [43] (Figure 3). In contrast, but in accordance with the time window of efficacy to the promoting effect of novelty, when tasks were separated by a larger time lapse, LTM of habituation was present. We also demonstrated that when subjects are trained in a wIA and explore two different and novel OF arenas (1 h before and 15 min after wIA training), IA-LTM is further improved. In parallel, whereas LTM for the first OF is impaired when wIA is intercalated between both exploratory sessions, the second OF-LTM was preserved [43]. In such scenario, we concluded that the levels of PRPs may be insufficient to satisfy the LTM requirements of the three behavioral tasks and thus not all mnemonic traces would be consolidated.


Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis.

Moncada D, Ballarini F, Viola H - Neural Plast. (2015)

Competence for PRPs in LTM formation. A strong training not only triggers the synthesis of PRPs (red circle) but also induces its learning tag (dashed-dotted circle). Weak training experienced close to the strong one only set its corresponding learning tag (dashed-circle). So, these different types of tags could compete inside a cell to capture the PRPs that are available around them. If the amount of proteins is limited it was observed that one LTM is promoted and the other one is impaired. This process should be accomplished in a subset of cells which were activated by both training experiences.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4562088&req=5

fig3: Competence for PRPs in LTM formation. A strong training not only triggers the synthesis of PRPs (red circle) but also induces its learning tag (dashed-dotted circle). Weak training experienced close to the strong one only set its corresponding learning tag (dashed-circle). So, these different types of tags could compete inside a cell to capture the PRPs that are available around them. If the amount of proteins is limited it was observed that one LTM is promoted and the other one is impaired. This process should be accomplished in a subset of cells which were activated by both training experiences.
Mentions: We hypothesize that if different learning experiences are being consolidated into LTM, intracellular competition for PRPs among their respective learning tags will define which of the memory traces becomes stabilized in the neuronal network. Based on the protocols of the first BT experiments [32], this has been tested by combining wIA and novel OF, two tasks that are dependent on hippocampus processing. If rats are sequentially exposed to two different memory tasks under limited protein synthesis, OF exploration promotes IA-LTM formation from a wIA training session and this occurs in detriment of the OF's LTM [43] (Figure 3). In contrast, but in accordance with the time window of efficacy to the promoting effect of novelty, when tasks were separated by a larger time lapse, LTM of habituation was present. We also demonstrated that when subjects are trained in a wIA and explore two different and novel OF arenas (1 h before and 15 min after wIA training), IA-LTM is further improved. In parallel, whereas LTM for the first OF is impaired when wIA is intercalated between both exploratory sessions, the second OF-LTM was preserved [43]. In such scenario, we concluded that the levels of PRPs may be insufficient to satisfy the LTM requirements of the three behavioral tasks and thus not all mnemonic traces would be consolidated.

Bottom Line: BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins.In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory.We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Biologia Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina.

ABSTRACT
Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced in the network. The synaptic tagging and capture theory provided a strong framework to explain synaptic specificity and persistence of electrophysiological induced plastic changes. Ten years later, the behavioral tagging hypothesis (BT) made use of the same argument, applying it to learning and memory models. The hypothesis postulates that the formation of lasting memories relies on at least two processes: the setting of a learning tag and the synthesis of plasticity related proteins, which once captured at tagged sites allow memory consolidation. BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins. In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory. We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

No MeSH data available.


Related in: MedlinePlus