Limits...
Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis.

Moncada D, Ballarini F, Viola H - Neural Plast. (2015)

Bottom Line: BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins.In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory.We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Biologia Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina.

ABSTRACT
Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced in the network. The synaptic tagging and capture theory provided a strong framework to explain synaptic specificity and persistence of electrophysiological induced plastic changes. Ten years later, the behavioral tagging hypothesis (BT) made use of the same argument, applying it to learning and memory models. The hypothesis postulates that the formation of lasting memories relies on at least two processes: the setting of a learning tag and the synthesis of plasticity related proteins, which once captured at tagged sites allow memory consolidation. BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins. In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory. We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

No MeSH data available.


The behavioral tagging process in different learning tasks and animal models. The figure resumes the effects on LTM for different learning tasks associated to another event (associated event) at different time relative to the training session. LTM was generally measured 24 h after training, and it could be promoted/improved, or not. It also shows whether the effect on LTM was reported to be dependent on new protein synthesis, the animal models where the research was conducted, and all the behavioral and pharmacological interventions used as associated event.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4562088&req=5

fig2: The behavioral tagging process in different learning tasks and animal models. The figure resumes the effects on LTM for different learning tasks associated to another event (associated event) at different time relative to the training session. LTM was generally measured 24 h after training, and it could be promoted/improved, or not. It also shows whether the effect on LTM was reported to be dependent on new protein synthesis, the animal models where the research was conducted, and all the behavioral and pharmacological interventions used as associated event.

Mentions: These predictions were tested in different learning and memory tasks or activities performed in rodents and humans, and the results are enumerated in the following sections and summarized in Figure 2. Moreover, the BT hypothesis comprised a wide theoretical framework that led us to explain many other questions about memory processing. So other predictions derived from this hypothesis deserve investigation and some of them will be mentioned in the concluding remarks section.


Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis.

Moncada D, Ballarini F, Viola H - Neural Plast. (2015)

The behavioral tagging process in different learning tasks and animal models. The figure resumes the effects on LTM for different learning tasks associated to another event (associated event) at different time relative to the training session. LTM was generally measured 24 h after training, and it could be promoted/improved, or not. It also shows whether the effect on LTM was reported to be dependent on new protein synthesis, the animal models where the research was conducted, and all the behavioral and pharmacological interventions used as associated event.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4562088&req=5

fig2: The behavioral tagging process in different learning tasks and animal models. The figure resumes the effects on LTM for different learning tasks associated to another event (associated event) at different time relative to the training session. LTM was generally measured 24 h after training, and it could be promoted/improved, or not. It also shows whether the effect on LTM was reported to be dependent on new protein synthesis, the animal models where the research was conducted, and all the behavioral and pharmacological interventions used as associated event.
Mentions: These predictions were tested in different learning and memory tasks or activities performed in rodents and humans, and the results are enumerated in the following sections and summarized in Figure 2. Moreover, the BT hypothesis comprised a wide theoretical framework that led us to explain many other questions about memory processing. So other predictions derived from this hypothesis deserve investigation and some of them will be mentioned in the concluding remarks section.

Bottom Line: BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins.In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory.We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Biologia Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina.

ABSTRACT
Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced in the network. The synaptic tagging and capture theory provided a strong framework to explain synaptic specificity and persistence of electrophysiological induced plastic changes. Ten years later, the behavioral tagging hypothesis (BT) made use of the same argument, applying it to learning and memory models. The hypothesis postulates that the formation of lasting memories relies on at least two processes: the setting of a learning tag and the synthesis of plasticity related proteins, which once captured at tagged sites allow memory consolidation. BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins. In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory. We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

No MeSH data available.