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Primo Vascular System: An Endothelial-to-Mesenchymal Potential Transitional Tissue Involved in Gastric Cancer Metastasis.

Ping A, Zhendong S, Rongmei Q, Jingxing D, Wei C, Zhongyin Z, Hesheng L, Soh KS - Evid Based Complement Alternat Med (2015)

Bottom Line: We observed blood vessel-mediated metastasis, primo vessel-mediated metastasis, and an intermediate state between them.We deduced that primo vessels may be precursors of blood vessels.These results possibly provided a thoroughly new theoretic development in cancer metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430070, China.

ABSTRACT
Gastric cancer is the fourth commonest cancer in the world and the second leading cause of cancer-related death. Investigation of gastric cancer metastasis is one of the hottest and major focuses in cancer research. Growing evidence manifested that primo vascular system (PVS) is a new kind of circulatory system beyond vascular and lymphatic system. Previous researches revealed that PVS is a specific tissue between endothelium and mesenchyme and is involved in cancer, especially in tumor metastasis and regeneration. In current study, we investigated the role of primo vessels in gastric cancer metastasis and its possible relationship to vascular vessels formation. Our results indicated that primo vessels were involved in gastric cancer metastasis. We observed blood vessel-mediated metastasis, primo vessel-mediated metastasis, and an intermediate state between them. We deduced that primo vessels may be precursors of blood vessels. These results possibly provided a thoroughly new theoretic development in cancer metastasis.

No MeSH data available.


Related in: MedlinePlus

Primo vessels were distinct from vascular vessels and lymphatic vessels. Weak CD31 fluorescence (an endothelium marker) was observed in primo vessels while strong CD31 expression was detected in vascular vessels. Furthermore, primo vessels negatively expressed LYVI-1 (a lymphatic endothelium marker).
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fig4: Primo vessels were distinct from vascular vessels and lymphatic vessels. Weak CD31 fluorescence (an endothelium marker) was observed in primo vessels while strong CD31 expression was detected in vascular vessels. Furthermore, primo vessels negatively expressed LYVI-1 (a lymphatic endothelium marker).

Mentions: We further studied the biologic features of primo vessels involved in gastric metastasis. Our results indicated that contrast to vascular vessels and lymphatic vessels, primo vessels expressed weak CD31 (a endothelium marker) and negative LYVE-1 (a lymphatic endothelium marker) (Figure 4). These data supported our previous opinion that primo vessels belong to a type of endothelial-to-mesenchymal transitional tissues [11] and suggested them as a new metastatic pathway in gastric metastasis. This is another new finding and proof that revealed the role of primo vascular system in cancer metastasis.


Primo Vascular System: An Endothelial-to-Mesenchymal Potential Transitional Tissue Involved in Gastric Cancer Metastasis.

Ping A, Zhendong S, Rongmei Q, Jingxing D, Wei C, Zhongyin Z, Hesheng L, Soh KS - Evid Based Complement Alternat Med (2015)

Primo vessels were distinct from vascular vessels and lymphatic vessels. Weak CD31 fluorescence (an endothelium marker) was observed in primo vessels while strong CD31 expression was detected in vascular vessels. Furthermore, primo vessels negatively expressed LYVI-1 (a lymphatic endothelium marker).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4562087&req=5

fig4: Primo vessels were distinct from vascular vessels and lymphatic vessels. Weak CD31 fluorescence (an endothelium marker) was observed in primo vessels while strong CD31 expression was detected in vascular vessels. Furthermore, primo vessels negatively expressed LYVI-1 (a lymphatic endothelium marker).
Mentions: We further studied the biologic features of primo vessels involved in gastric metastasis. Our results indicated that contrast to vascular vessels and lymphatic vessels, primo vessels expressed weak CD31 (a endothelium marker) and negative LYVE-1 (a lymphatic endothelium marker) (Figure 4). These data supported our previous opinion that primo vessels belong to a type of endothelial-to-mesenchymal transitional tissues [11] and suggested them as a new metastatic pathway in gastric metastasis. This is another new finding and proof that revealed the role of primo vascular system in cancer metastasis.

Bottom Line: We observed blood vessel-mediated metastasis, primo vessel-mediated metastasis, and an intermediate state between them.We deduced that primo vessels may be precursors of blood vessels.These results possibly provided a thoroughly new theoretic development in cancer metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430070, China.

ABSTRACT
Gastric cancer is the fourth commonest cancer in the world and the second leading cause of cancer-related death. Investigation of gastric cancer metastasis is one of the hottest and major focuses in cancer research. Growing evidence manifested that primo vascular system (PVS) is a new kind of circulatory system beyond vascular and lymphatic system. Previous researches revealed that PVS is a specific tissue between endothelium and mesenchyme and is involved in cancer, especially in tumor metastasis and regeneration. In current study, we investigated the role of primo vessels in gastric cancer metastasis and its possible relationship to vascular vessels formation. Our results indicated that primo vessels were involved in gastric cancer metastasis. We observed blood vessel-mediated metastasis, primo vessel-mediated metastasis, and an intermediate state between them. We deduced that primo vessels may be precursors of blood vessels. These results possibly provided a thoroughly new theoretic development in cancer metastasis.

No MeSH data available.


Related in: MedlinePlus