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Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?

Köhler CA, Carvalho AF, Alves GS, McIntyre RS, Hyphantis TN, Cammarota M - Neural Plast. (2015)

Bottom Line: Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories.Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographical memories in both healthy and depressive individuals.We review strategies for this clinical domain, including memory specificity training, method-of-loci, memory rescripting, and real-time fMRI neurofeedback training of amygdala activity in depression.

View Article: PubMed Central - PubMed

Affiliation: Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte (UFRN), 59056-450 Natal, RN, Brazil.

ABSTRACT
Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of overgeneral memories in detriment of specific autobiographical memories; and the role of ruminative processes and avoidance when dealing with autobiographical memories. Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographical memories in both healthy and depressive individuals. Disruptions in autobiographical memories predispose and portend onset and maintenance of depression. Thus, we discuss emerging therapeutics that target memory difficulties in those with depression. We review strategies for this clinical domain, including memory specificity training, method-of-loci, memory rescripting, and real-time fMRI neurofeedback training of amygdala activity in depression. We propose that the manipulation of the reconsolidation of autobiographical memories in depression might represent a novel yet largely unexplored, domain-specific, therapeutic opportunity for depression treatment.

No MeSH data available.


Related in: MedlinePlus

The method-of-loci (MoL). Associating a memory to loci in a familiar route might be used to enhance the retrieval of positive autobiographical memories in depression.
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Related In: Results  -  Collection


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fig2: The method-of-loci (MoL). Associating a memory to loci in a familiar route might be used to enhance the retrieval of positive autobiographical memories in depression.

Mentions: The method-of-loci (MoL) is an ancient mnemonic method that relies on memorized spatial relationships between loci that are used to arrange and recollect episodic memories [34]. The basic paradigm aims to incorporate visual imagery to each to-be-recollected piece of information with one of the loci along a route. MoL significantly ameliorated memory performance in naïve participants [101, 102]. In an initial, nonrandomized study, MoL was compared to a chunking-and-rehearsal technique in small sample of participants with major depressive disorder [18]. Participants completed a week of retrieved training until the point they could recollect all their identified memories without error. On a surprise recall test after a further week, only participants allocated to MoL training exhibited a “ceiling” memory recollection. Notwithstanding, the MoL is a promising and simple tool to enhance the assessment of elaborated positive memories in depression; these findings deserve replication in a larger randomized trial. Figure 2 depicts a hypothetical worked example of this approach. The MoL involves the incorporation of new information into an existing memory trace, which may in turn involve reconsolidation mechanisms. Thus, a careful scrutiny of the conditions under which the reactivation and updating is conducted may (at least in theory) improve its overall efficacy (vide supra).


Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?

Köhler CA, Carvalho AF, Alves GS, McIntyre RS, Hyphantis TN, Cammarota M - Neural Plast. (2015)

The method-of-loci (MoL). Associating a memory to loci in a familiar route might be used to enhance the retrieval of positive autobiographical memories in depression.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4561987&req=5

fig2: The method-of-loci (MoL). Associating a memory to loci in a familiar route might be used to enhance the retrieval of positive autobiographical memories in depression.
Mentions: The method-of-loci (MoL) is an ancient mnemonic method that relies on memorized spatial relationships between loci that are used to arrange and recollect episodic memories [34]. The basic paradigm aims to incorporate visual imagery to each to-be-recollected piece of information with one of the loci along a route. MoL significantly ameliorated memory performance in naïve participants [101, 102]. In an initial, nonrandomized study, MoL was compared to a chunking-and-rehearsal technique in small sample of participants with major depressive disorder [18]. Participants completed a week of retrieved training until the point they could recollect all their identified memories without error. On a surprise recall test after a further week, only participants allocated to MoL training exhibited a “ceiling” memory recollection. Notwithstanding, the MoL is a promising and simple tool to enhance the assessment of elaborated positive memories in depression; these findings deserve replication in a larger randomized trial. Figure 2 depicts a hypothetical worked example of this approach. The MoL involves the incorporation of new information into an existing memory trace, which may in turn involve reconsolidation mechanisms. Thus, a careful scrutiny of the conditions under which the reactivation and updating is conducted may (at least in theory) improve its overall efficacy (vide supra).

Bottom Line: Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories.Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographical memories in both healthy and depressive individuals.We review strategies for this clinical domain, including memory specificity training, method-of-loci, memory rescripting, and real-time fMRI neurofeedback training of amygdala activity in depression.

View Article: PubMed Central - PubMed

Affiliation: Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte (UFRN), 59056-450 Natal, RN, Brazil.

ABSTRACT
Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of overgeneral memories in detriment of specific autobiographical memories; and the role of ruminative processes and avoidance when dealing with autobiographical memories. Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographical memories in both healthy and depressive individuals. Disruptions in autobiographical memories predispose and portend onset and maintenance of depression. Thus, we discuss emerging therapeutics that target memory difficulties in those with depression. We review strategies for this clinical domain, including memory specificity training, method-of-loci, memory rescripting, and real-time fMRI neurofeedback training of amygdala activity in depression. We propose that the manipulation of the reconsolidation of autobiographical memories in depression might represent a novel yet largely unexplored, domain-specific, therapeutic opportunity for depression treatment.

No MeSH data available.


Related in: MedlinePlus