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Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study.

Gao LH, Zhu WJ, Liu YJ, Gu JM, Zhang ZL, Wang O, Xing XP, Xu L - Acta Pharmacol. Sin. (2015)

Bottom Line: Serum levels of 25-hydroxyvitamin D were significantly increased in group C, but not changed in groups A and B at 24-month follow-up.The participants in group C maintained the grip strength, while those in groups A and B exhibited decreased grip strength at 24-month follow-up.Supplementation with calcitriol and calcium modifies the bone turnover marker levels, and maintains muscle strength and quality of life in postmenopausal Chinese women, whereas supplementation with cholecalciferol and calcium prevents aging-mediated deterioration in quality of life.

View Article: PubMed Central - PubMed

Affiliation: Metabolic Bone Diseases and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

ABSTRACT

Aim: To investigate the effects of calcium and vitamin D supplementation on bone turnover marker levels, muscle strength and quality of life in postmenopausal Chinese women.

Methods: A total of 485 healthy postmenopausal Chinese women (63.44±5.04 years) were enrolled in this open-label, 2-year, prospective, community-based trial. The participants were divided into group A, B, C, which were treated with calcium (600 mg/d) alone, calcium (600 mg/d) and cholecalciferol (800 IU/d) or calcium (600 mg/d) and calcitriol (0.25 μg/d), respectively, for 2 years. Serum levels of 25-hydroxyvitamin D, parathyroid hormone, β-CTX and P1NP were measured, and the muscle strength and quality of life were assessed at baseline and at 12- and 24-month follow-ups.

Results: Four hundred and sixty one participants completed this study. Serum levels of 25-hydroxyvitamin D were significantly increased in group C, but not changed in groups A and B at 24-month follow-up. Serum levels of parathyroid hormone, bone turnover marker β-CTX and bone formation marker P1NP were significantly decreased in group C, while serum levels of β-CTX were increased in group A at 24-month follow-up. The participants in group C maintained the grip strength, while those in groups A and B exhibited decreased grip strength at 24-month follow-up. The quality of life for the participants in groups B and C remained consistent, but that in group A was deteriorated at 24-month follow-up.

Conclusion: Supplementation with calcitriol and calcium modifies the bone turnover marker levels, and maintains muscle strength and quality of life in postmenopausal Chinese women, whereas supplementation with cholecalciferol and calcium prevents aging-mediated deterioration in quality of life.

No MeSH data available.


Related in: MedlinePlus

Flowchart describing the study.
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fig1: Flowchart describing the study.

Mentions: Figure 1 presents a flowchart describing the study. A total of 485 postmenopausal women who presented normal indicators of liver and kidney function and blood calcium and phosphorus levels were included in the study and were separated into three groups. Nine subjects withdrew from the study to receive anti-osteoporosis treatment. Two subjects were lost to follow-up because they changed their addresses. Twelve subjects failed to complete the study for unknown reasons. Ultimately, 461 participants completed the study. At the 12-month and 24-month follow-ups, the serum concentrations of calcium, phosphorous, and PTH and the results of liver and kidney function in the three groups all remained within normal ranges. No obvious adverse events were reported over the course of the study.


Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study.

Gao LH, Zhu WJ, Liu YJ, Gu JM, Zhang ZL, Wang O, Xing XP, Xu L - Acta Pharmacol. Sin. (2015)

Flowchart describing the study.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4561972&req=5

fig1: Flowchart describing the study.
Mentions: Figure 1 presents a flowchart describing the study. A total of 485 postmenopausal women who presented normal indicators of liver and kidney function and blood calcium and phosphorus levels were included in the study and were separated into three groups. Nine subjects withdrew from the study to receive anti-osteoporosis treatment. Two subjects were lost to follow-up because they changed their addresses. Twelve subjects failed to complete the study for unknown reasons. Ultimately, 461 participants completed the study. At the 12-month and 24-month follow-ups, the serum concentrations of calcium, phosphorous, and PTH and the results of liver and kidney function in the three groups all remained within normal ranges. No obvious adverse events were reported over the course of the study.

Bottom Line: Serum levels of 25-hydroxyvitamin D were significantly increased in group C, but not changed in groups A and B at 24-month follow-up.The participants in group C maintained the grip strength, while those in groups A and B exhibited decreased grip strength at 24-month follow-up.Supplementation with calcitriol and calcium modifies the bone turnover marker levels, and maintains muscle strength and quality of life in postmenopausal Chinese women, whereas supplementation with cholecalciferol and calcium prevents aging-mediated deterioration in quality of life.

View Article: PubMed Central - PubMed

Affiliation: Metabolic Bone Diseases and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

ABSTRACT

Aim: To investigate the effects of calcium and vitamin D supplementation on bone turnover marker levels, muscle strength and quality of life in postmenopausal Chinese women.

Methods: A total of 485 healthy postmenopausal Chinese women (63.44±5.04 years) were enrolled in this open-label, 2-year, prospective, community-based trial. The participants were divided into group A, B, C, which were treated with calcium (600 mg/d) alone, calcium (600 mg/d) and cholecalciferol (800 IU/d) or calcium (600 mg/d) and calcitriol (0.25 μg/d), respectively, for 2 years. Serum levels of 25-hydroxyvitamin D, parathyroid hormone, β-CTX and P1NP were measured, and the muscle strength and quality of life were assessed at baseline and at 12- and 24-month follow-ups.

Results: Four hundred and sixty one participants completed this study. Serum levels of 25-hydroxyvitamin D were significantly increased in group C, but not changed in groups A and B at 24-month follow-up. Serum levels of parathyroid hormone, bone turnover marker β-CTX and bone formation marker P1NP were significantly decreased in group C, while serum levels of β-CTX were increased in group A at 24-month follow-up. The participants in group C maintained the grip strength, while those in groups A and B exhibited decreased grip strength at 24-month follow-up. The quality of life for the participants in groups B and C remained consistent, but that in group A was deteriorated at 24-month follow-up.

Conclusion: Supplementation with calcitriol and calcium modifies the bone turnover marker levels, and maintains muscle strength and quality of life in postmenopausal Chinese women, whereas supplementation with cholecalciferol and calcium prevents aging-mediated deterioration in quality of life.

No MeSH data available.


Related in: MedlinePlus