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Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease.

Hafkemeijer A, Möller C, Dopper EG, Jiskoot LC, Schouten TM, van Swieten JC, van der Flier WM, Vrenken H, Pijnenburg YA, Barkhof F, Scheltens P, van der Grond J, Rombouts SA - Front Hum Neurosci (2015)

Bottom Line: Given gray matter differences, we observed decreased network-to-region connectivity in bvFTD between (a) lateral visual cortical network and lateral occipital and cuneal cortex, and (b) auditory system network and angular gyrus.In AD, we found decreased network-to-region connectivity between the dorsal visual stream network and lateral occipital and parietal opercular cortex.Region-to-region connectivity was decreased in bvFTD between superior temporal gyrus and cuneal, supracalcarine, intracalcarine cortex, and lingual gyrus.

View Article: PubMed Central - PubMed

Affiliation: Department of Methodology and Statistics, Institute of Psychology, Leiden University Leiden, Netherlands ; Department of Radiology, Leiden University Medical Center Leiden, Netherlands ; Leiden Institute for Brain and Cognition, Leiden University Leiden, Netherlands.

ABSTRACT

Introduction: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are the most common types of early-onset dementia. Early differentiation between both types of dementia may be challenging due to heterogeneity and overlap of symptoms. Here, we apply resting state functional magnetic resonance imaging (fMRI) to study functional brain connectivity differences between AD and bvFTD.

Methods: We used resting state fMRI data of 31 AD patients, 25 bvFTD patients, and 29 controls from two centers specialized in dementia. We studied functional connectivity throughout the entire brain, applying two different analysis techniques, studying network-to-region and region-to-region connectivity. A general linear model approach was used to study group differences, while controlling for physiological noise, age, gender, study center, and regional gray matter volume.

Results: Given gray matter differences, we observed decreased network-to-region connectivity in bvFTD between (a) lateral visual cortical network and lateral occipital and cuneal cortex, and (b) auditory system network and angular gyrus. In AD, we found decreased network-to-region connectivity between the dorsal visual stream network and lateral occipital and parietal opercular cortex. Region-to-region connectivity was decreased in bvFTD between superior temporal gyrus and cuneal, supracalcarine, intracalcarine cortex, and lingual gyrus.

Conclusion: We showed that the pathophysiology of functional brain connectivity is different between AD and bvFTD. Our findings support the hypothesis that resting state fMRI shows disease-specific functional connectivity differences and is useful to elucidate the pathophysiology of AD and bvFTD. However, the group differences in functional connectivity are less abundant than has been shown in previous studies.

No MeSH data available.


Related in: MedlinePlus

Group differences in gray matter volume. Differences in gray matter volume between behavioral variant frontotemporal dementia (FTD), Alzheimer's disease (AD), and healthy controls (HC) (TFCE, FWE-corrected). (A) Patients with AD showed less gray matter in precuneal cortex, posterior cingulate cortex, and frontal medial cortex compared with controls. (B) Patients with bvFTD showed less gray matter in anterior cingulate cortex, insular cortex, frontal pole, frontal gyrus, and middle temporal gyrus compared with controls. (C) AD patients had less gray matter compared with bvFTD in precuneal cortex and posterior cingulate cortex. (D) Patients with bvFTD had less gray matter compared with AD in anterior cingulate gyrus and frontal pole.
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Figure 1: Group differences in gray matter volume. Differences in gray matter volume between behavioral variant frontotemporal dementia (FTD), Alzheimer's disease (AD), and healthy controls (HC) (TFCE, FWE-corrected). (A) Patients with AD showed less gray matter in precuneal cortex, posterior cingulate cortex, and frontal medial cortex compared with controls. (B) Patients with bvFTD showed less gray matter in anterior cingulate cortex, insular cortex, frontal pole, frontal gyrus, and middle temporal gyrus compared with controls. (C) AD patients had less gray matter compared with bvFTD in precuneal cortex and posterior cingulate cortex. (D) Patients with bvFTD had less gray matter compared with AD in anterior cingulate gyrus and frontal pole.

Mentions: The voxel-wise structural analysis revealed group differences in gray matter volume (Figure 1). Patients with AD showed less gray matter in precuneal cortex, posterior cingulate cortex, frontal medial cortex, temporal gyrus, hippocampus, lateral occipital cortex, and operculum cortex compared with controls (Figure 1A). Patients with bvFTD showed less gray matter in anterior cingulate cortex, insular cortex, frontal pole, frontal gyrus, temporal pole, temporal gyrus, and temporal fusiform gyrus compared with controls (Figure 1B). AD patients had less gray matter compared with bvFTD in precuneal cortex, posterior cingulate cortex, and angular gyrus (Figure 1C). Patients with bvFTD had less gray matter compared with AD in anterior cingulate gyrus, frontal pole, and superior frontal gyrus (Figure 1D).


Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease.

Hafkemeijer A, Möller C, Dopper EG, Jiskoot LC, Schouten TM, van Swieten JC, van der Flier WM, Vrenken H, Pijnenburg YA, Barkhof F, Scheltens P, van der Grond J, Rombouts SA - Front Hum Neurosci (2015)

Group differences in gray matter volume. Differences in gray matter volume between behavioral variant frontotemporal dementia (FTD), Alzheimer's disease (AD), and healthy controls (HC) (TFCE, FWE-corrected). (A) Patients with AD showed less gray matter in precuneal cortex, posterior cingulate cortex, and frontal medial cortex compared with controls. (B) Patients with bvFTD showed less gray matter in anterior cingulate cortex, insular cortex, frontal pole, frontal gyrus, and middle temporal gyrus compared with controls. (C) AD patients had less gray matter compared with bvFTD in precuneal cortex and posterior cingulate cortex. (D) Patients with bvFTD had less gray matter compared with AD in anterior cingulate gyrus and frontal pole.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4561903&req=5

Figure 1: Group differences in gray matter volume. Differences in gray matter volume between behavioral variant frontotemporal dementia (FTD), Alzheimer's disease (AD), and healthy controls (HC) (TFCE, FWE-corrected). (A) Patients with AD showed less gray matter in precuneal cortex, posterior cingulate cortex, and frontal medial cortex compared with controls. (B) Patients with bvFTD showed less gray matter in anterior cingulate cortex, insular cortex, frontal pole, frontal gyrus, and middle temporal gyrus compared with controls. (C) AD patients had less gray matter compared with bvFTD in precuneal cortex and posterior cingulate cortex. (D) Patients with bvFTD had less gray matter compared with AD in anterior cingulate gyrus and frontal pole.
Mentions: The voxel-wise structural analysis revealed group differences in gray matter volume (Figure 1). Patients with AD showed less gray matter in precuneal cortex, posterior cingulate cortex, frontal medial cortex, temporal gyrus, hippocampus, lateral occipital cortex, and operculum cortex compared with controls (Figure 1A). Patients with bvFTD showed less gray matter in anterior cingulate cortex, insular cortex, frontal pole, frontal gyrus, temporal pole, temporal gyrus, and temporal fusiform gyrus compared with controls (Figure 1B). AD patients had less gray matter compared with bvFTD in precuneal cortex, posterior cingulate cortex, and angular gyrus (Figure 1C). Patients with bvFTD had less gray matter compared with AD in anterior cingulate gyrus, frontal pole, and superior frontal gyrus (Figure 1D).

Bottom Line: Given gray matter differences, we observed decreased network-to-region connectivity in bvFTD between (a) lateral visual cortical network and lateral occipital and cuneal cortex, and (b) auditory system network and angular gyrus.In AD, we found decreased network-to-region connectivity between the dorsal visual stream network and lateral occipital and parietal opercular cortex.Region-to-region connectivity was decreased in bvFTD between superior temporal gyrus and cuneal, supracalcarine, intracalcarine cortex, and lingual gyrus.

View Article: PubMed Central - PubMed

Affiliation: Department of Methodology and Statistics, Institute of Psychology, Leiden University Leiden, Netherlands ; Department of Radiology, Leiden University Medical Center Leiden, Netherlands ; Leiden Institute for Brain and Cognition, Leiden University Leiden, Netherlands.

ABSTRACT

Introduction: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are the most common types of early-onset dementia. Early differentiation between both types of dementia may be challenging due to heterogeneity and overlap of symptoms. Here, we apply resting state functional magnetic resonance imaging (fMRI) to study functional brain connectivity differences between AD and bvFTD.

Methods: We used resting state fMRI data of 31 AD patients, 25 bvFTD patients, and 29 controls from two centers specialized in dementia. We studied functional connectivity throughout the entire brain, applying two different analysis techniques, studying network-to-region and region-to-region connectivity. A general linear model approach was used to study group differences, while controlling for physiological noise, age, gender, study center, and regional gray matter volume.

Results: Given gray matter differences, we observed decreased network-to-region connectivity in bvFTD between (a) lateral visual cortical network and lateral occipital and cuneal cortex, and (b) auditory system network and angular gyrus. In AD, we found decreased network-to-region connectivity between the dorsal visual stream network and lateral occipital and parietal opercular cortex. Region-to-region connectivity was decreased in bvFTD between superior temporal gyrus and cuneal, supracalcarine, intracalcarine cortex, and lingual gyrus.

Conclusion: We showed that the pathophysiology of functional brain connectivity is different between AD and bvFTD. Our findings support the hypothesis that resting state fMRI shows disease-specific functional connectivity differences and is useful to elucidate the pathophysiology of AD and bvFTD. However, the group differences in functional connectivity are less abundant than has been shown in previous studies.

No MeSH data available.


Related in: MedlinePlus