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Polymeric and Solid Lipid Nanoparticles for Sustained Release of Carbendazim and Tebuconazole in Agricultural Applications.

Campos EV, de Oliveira JL, da Silva CM, Pascoli M, Pasquoto T, Lima R, Abhilash PC, Fraceto LF - Sci Rep (2015)

Bottom Line: Both nanoparticle systems presented high association efficiency (>99%), indicating good interaction between the fungicides and the nanoparticles.The release profiles of MBC and TBZ were modified when the compounds were loaded in the nanoparticles, and cytotoxicity assays showed that encapsulation of the fungicides decreased their toxicity.These fungicide systems offer new options for the treatment and prevention of fungal diseases in plants.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Engineering, State University of São Paulo (UNESP), Sorocaba, SP, Brazil.

ABSTRACT
Carbendazim (MBC) (methyl-2-benzimidazole carbamate) and tebuconazole (TBZ) ((RS)-1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol) are widely used in agriculture for the prevention and control of fungal diseases. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of bioactive compounds and their transfer to the site of action, reduced losses due to leaching or degradation, and decreased toxicity in the environment and humans. The objective of this study was to prepare these two types of nanoparticle as carrier systems for a combination of TBZ and MBC, and then investigate the release profiles of the fungicides as well as the stabilities and cytotoxicities of the formulations. Both nanoparticle systems presented high association efficiency (>99%), indicating good interaction between the fungicides and the nanoparticles. The release profiles of MBC and TBZ were modified when the compounds were loaded in the nanoparticles, and cytotoxicity assays showed that encapsulation of the fungicides decreased their toxicity. These fungicide systems offer new options for the treatment and prevention of fungal diseases in plants.

No MeSH data available.


Related in: MedlinePlus

Temporal profiles of fungicide release.Cumulative release of (A) MBC and (B) TBZ in suspensions of nanoparticles (NCs and SLNs). The tests were performed in triplicate.
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f6: Temporal profiles of fungicide release.Cumulative release of (A) MBC and (B) TBZ in suspensions of nanoparticles (NCs and SLNs). The tests were performed in triplicate.

Mentions: As the characterization and the cytotoxicity results indicates good results for these systems, the release kinetics were investigated. The release kinetics can provide important information concerning the interaction between a bioactive compound and a carrier, as well as the mechanism involved in the release process464719. Figure 6 shows the curves obtained for release of the fungicides from the NCs and SLNs. The assays were performed in tube systems, where the nanoparticle formulations were placed in contact with a solvent (deionized water) in order to release the fungicides from the nanoparticles. This enabled the evaluation of the effect of the encapsulation on the rate of release of the fungicides. The release profiles showed that there was substantial release of MBC during the first 600 min of the experiment, after which the release became more gradual. The release profiles of the two nanoparticle formulations were similar, with release of only around 28% and 30% of the MBC after 6 days, for the NCs and SLNs, respectively. These observations provided clear evidence of the capacity of the nanoparticles to modulate the fungicide release profiles.


Polymeric and Solid Lipid Nanoparticles for Sustained Release of Carbendazim and Tebuconazole in Agricultural Applications.

Campos EV, de Oliveira JL, da Silva CM, Pascoli M, Pasquoto T, Lima R, Abhilash PC, Fraceto LF - Sci Rep (2015)

Temporal profiles of fungicide release.Cumulative release of (A) MBC and (B) TBZ in suspensions of nanoparticles (NCs and SLNs). The tests were performed in triplicate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4561881&req=5

f6: Temporal profiles of fungicide release.Cumulative release of (A) MBC and (B) TBZ in suspensions of nanoparticles (NCs and SLNs). The tests were performed in triplicate.
Mentions: As the characterization and the cytotoxicity results indicates good results for these systems, the release kinetics were investigated. The release kinetics can provide important information concerning the interaction between a bioactive compound and a carrier, as well as the mechanism involved in the release process464719. Figure 6 shows the curves obtained for release of the fungicides from the NCs and SLNs. The assays were performed in tube systems, where the nanoparticle formulations were placed in contact with a solvent (deionized water) in order to release the fungicides from the nanoparticles. This enabled the evaluation of the effect of the encapsulation on the rate of release of the fungicides. The release profiles showed that there was substantial release of MBC during the first 600 min of the experiment, after which the release became more gradual. The release profiles of the two nanoparticle formulations were similar, with release of only around 28% and 30% of the MBC after 6 days, for the NCs and SLNs, respectively. These observations provided clear evidence of the capacity of the nanoparticles to modulate the fungicide release profiles.

Bottom Line: Both nanoparticle systems presented high association efficiency (>99%), indicating good interaction between the fungicides and the nanoparticles.The release profiles of MBC and TBZ were modified when the compounds were loaded in the nanoparticles, and cytotoxicity assays showed that encapsulation of the fungicides decreased their toxicity.These fungicide systems offer new options for the treatment and prevention of fungal diseases in plants.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Engineering, State University of São Paulo (UNESP), Sorocaba, SP, Brazil.

ABSTRACT
Carbendazim (MBC) (methyl-2-benzimidazole carbamate) and tebuconazole (TBZ) ((RS)-1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol) are widely used in agriculture for the prevention and control of fungal diseases. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of bioactive compounds and their transfer to the site of action, reduced losses due to leaching or degradation, and decreased toxicity in the environment and humans. The objective of this study was to prepare these two types of nanoparticle as carrier systems for a combination of TBZ and MBC, and then investigate the release profiles of the fungicides as well as the stabilities and cytotoxicities of the formulations. Both nanoparticle systems presented high association efficiency (>99%), indicating good interaction between the fungicides and the nanoparticles. The release profiles of MBC and TBZ were modified when the compounds were loaded in the nanoparticles, and cytotoxicity assays showed that encapsulation of the fungicides decreased their toxicity. These fungicide systems offer new options for the treatment and prevention of fungal diseases in plants.

No MeSH data available.


Related in: MedlinePlus