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The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese.

Ou-Yang F, Lin YD, Chuang LY, Chang HW, Yang CH, Hou MF - Biomed Res Int (2015)

Bottom Line: The ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis.However, the protective association model between the single nucleotide polymorphisms (SNPs) of ORAI1 gene was not investigated.Taken together, these results suggested that our proposed PSO strategy is powerful to identify the combinational SNPs of rs12320939, rs12313273, rs7135617, rs6486795, and rs712853 of ORAI1 gene with a strongly protective association in breast cancer.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Department of Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.

ABSTRACT
The ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis. However, the protective association model between the single nucleotide polymorphisms (SNPs) of ORAI1 gene was not investigated. Based on a published data set of 345 female breast cancer patients and 290 female controls, we used a particle swarm optimization (PSO) algorithm to identify the possible protective models of breast cancer association in terms of the SNPs of ORAI1 gene. Results showed that the PSO-generated models of 2-SNP (rs12320939-TT/rs12313273-CC), 3-SNP (rs12320939-TT/rs12313273-CC/rs712853-(TT/TC)), 4-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs712853-(TT/TC)), and 5-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs6486795-CC/rs712853-(TT/TC)) displayed low values of odds ratios (0.409-0.425) for breast cancer association. Taken together, these results suggested that our proposed PSO strategy is powerful to identify the combinational SNPs of rs12320939, rs12313273, rs7135617, rs6486795, and rs712853 of ORAI1 gene with a strongly protective association in breast cancer.

No MeSH data available.


Related in: MedlinePlus

Particle swarm optimization pseudocode.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4561876&req=5

alg1: Particle swarm optimization pseudocode.

Mentions: Algorithm 1 illustrates the PSO produce which has the four operations, including particle initializations, particle evaluations, pbest and gbest updates, and particle position update. The first step initializes the particles reasonable values. The second step computes the fitness values of particles. The third step updates the pbest of particle if the fitness value is better than the pbest. The fourth step updates the gbest if a fitness value of particle is better than the gbest. The fifth step updates the particle's velocity and position. The steps 2 to 5 are repeated until the maximum generation is achieved. Next, these four operations are introduced in detail as follows.


The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese.

Ou-Yang F, Lin YD, Chuang LY, Chang HW, Yang CH, Hou MF - Biomed Res Int (2015)

Particle swarm optimization pseudocode.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4561876&req=5

alg1: Particle swarm optimization pseudocode.
Mentions: Algorithm 1 illustrates the PSO produce which has the four operations, including particle initializations, particle evaluations, pbest and gbest updates, and particle position update. The first step initializes the particles reasonable values. The second step computes the fitness values of particles. The third step updates the pbest of particle if the fitness value is better than the pbest. The fourth step updates the gbest if a fitness value of particle is better than the gbest. The fifth step updates the particle's velocity and position. The steps 2 to 5 are repeated until the maximum generation is achieved. Next, these four operations are introduced in detail as follows.

Bottom Line: The ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis.However, the protective association model between the single nucleotide polymorphisms (SNPs) of ORAI1 gene was not investigated.Taken together, these results suggested that our proposed PSO strategy is powerful to identify the combinational SNPs of rs12320939, rs12313273, rs7135617, rs6486795, and rs712853 of ORAI1 gene with a strongly protective association in breast cancer.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Department of Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.

ABSTRACT
The ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis. However, the protective association model between the single nucleotide polymorphisms (SNPs) of ORAI1 gene was not investigated. Based on a published data set of 345 female breast cancer patients and 290 female controls, we used a particle swarm optimization (PSO) algorithm to identify the possible protective models of breast cancer association in terms of the SNPs of ORAI1 gene. Results showed that the PSO-generated models of 2-SNP (rs12320939-TT/rs12313273-CC), 3-SNP (rs12320939-TT/rs12313273-CC/rs712853-(TT/TC)), 4-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs712853-(TT/TC)), and 5-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs6486795-CC/rs712853-(TT/TC)) displayed low values of odds ratios (0.409-0.425) for breast cancer association. Taken together, these results suggested that our proposed PSO strategy is powerful to identify the combinational SNPs of rs12320939, rs12313273, rs7135617, rs6486795, and rs712853 of ORAI1 gene with a strongly protective association in breast cancer.

No MeSH data available.


Related in: MedlinePlus