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In utero Head Circumference is Associated with Childhood Allergy.

Eviston DP, Minasyan A, Mann KP, Campbell DE, Nanan RK - Front Pediatr (2015)

Bottom Line: Smaller head circumference at mid-gestation was associated with increased odds of allergic disease in children aged 1-5 years.A 1 mm smaller head circumference was associated with a 7% increased chance of allergies being later diagnosed, adjusted for gestation (95% CI: 1-14%, p = 0.036).Smaller mid-gestational head circumference is associated with early childhood allergic disease, which suggests that fetal programing of allergic disease occurs before mid-gestation.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Obstetrics, Gynaecology and Neonatology, Charles Perkins Centre Nepean, Sydney Medical School Nepean, The University of Sydney , Penrith, NSW , Australia.

ABSTRACT

Background: Altered fetal growth is known to be associated with allergic disease. Specifically, increased head circumference at birth has been linked to asthma and elevated IgE. However, few studies have examined a link between early fetal anthropometry and allergic disease. The aim of this study was to examine head circumference at mid-gestation in children diagnosed with allergy.

Methods: This was a retrospective cohort study, comprising pregnancies delivered between 10/2006 and 9/2010 at Nepean Hospital, Australia. Exclusion criteria were illegal drug use, alcohol consumption, gestation <35 weeks, and gestational hypertension. Pregnancy data were sourced from the Nepean Obstetric Database. Atopic diseases (asthma, atopic dermatitis, and IgE-mediated food allergy) were assessed by questionnaire at age 1-5 years. Infants from pregnancies with completed questionnaires, who also had a mid-gestation ultrasound scan, were included (N = 121). Multiple logistic regression techniques were used to model head circumference against the development of allergies.

Results: Smaller head circumference at mid-gestation was associated with increased odds of allergic disease in children aged 1-5 years. A 1 mm smaller head circumference was associated with a 7% increased chance of allergies being later diagnosed, adjusted for gestation (95% CI: 1-14%, p = 0.036). Head circumference at mid-gestation was also inversely correlated with the presence of multiple atopic disease.

Conclusion: Smaller mid-gestational head circumference is associated with early childhood allergic disease, which suggests that fetal programing of allergic disease occurs before mid-gestation. This suggests that mediators such as brain-derived neurotrophic factor may be dysregulated early in utero in a milieu, which also predisposes to atopic disease.

No MeSH data available.


Related in: MedlinePlus

Head circumference at mid-gestation vs. number of childhood allergies. Tukey boxplot, whereby “∙” represents a data point greater than the 75th percentile plus 1.5 times the interquartile range. 0 allergies (N = 80), 1 allergy (N = 30), ≥2 allergies (N = 11). An inverse relationship was observed between mid-gestation head circumference and the number of childhood allergies (p = 0.033).
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Figure 2: Head circumference at mid-gestation vs. number of childhood allergies. Tukey boxplot, whereby “∙” represents a data point greater than the 75th percentile plus 1.5 times the interquartile range. 0 allergies (N = 80), 1 allergy (N = 30), ≥2 allergies (N = 11). An inverse relationship was observed between mid-gestation head circumference and the number of childhood allergies (p = 0.033).

Mentions: Multiple logistic regression revealed small fetal head circumference at mid-gestation to be significantly linked to childhood allergy, adjusted for gestation at ultrasound, with each decrease of 1 mm associated with an increased risk of 7% increase in risk of allergy (95% CI: 1–14%, p = 0.036). Furthermore, ordinal logistic regression analysis found fetal head circumference at mid-gestation to be related to the number of childhood allergies. For a patient with no allergies, each 1-mm increase in head circumference corresponds to a 7% increased risk of having an allergy. Similarly, for a patient with one allergy, each 1-mm increase in head circumference corresponds to a 7% increased risk of having two or more allergies. [Figure 2; OR = 0.93 (95% CI: 0.80–0.99), p = 0.033].


In utero Head Circumference is Associated with Childhood Allergy.

Eviston DP, Minasyan A, Mann KP, Campbell DE, Nanan RK - Front Pediatr (2015)

Head circumference at mid-gestation vs. number of childhood allergies. Tukey boxplot, whereby “∙” represents a data point greater than the 75th percentile plus 1.5 times the interquartile range. 0 allergies (N = 80), 1 allergy (N = 30), ≥2 allergies (N = 11). An inverse relationship was observed between mid-gestation head circumference and the number of childhood allergies (p = 0.033).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4561811&req=5

Figure 2: Head circumference at mid-gestation vs. number of childhood allergies. Tukey boxplot, whereby “∙” represents a data point greater than the 75th percentile plus 1.5 times the interquartile range. 0 allergies (N = 80), 1 allergy (N = 30), ≥2 allergies (N = 11). An inverse relationship was observed between mid-gestation head circumference and the number of childhood allergies (p = 0.033).
Mentions: Multiple logistic regression revealed small fetal head circumference at mid-gestation to be significantly linked to childhood allergy, adjusted for gestation at ultrasound, with each decrease of 1 mm associated with an increased risk of 7% increase in risk of allergy (95% CI: 1–14%, p = 0.036). Furthermore, ordinal logistic regression analysis found fetal head circumference at mid-gestation to be related to the number of childhood allergies. For a patient with no allergies, each 1-mm increase in head circumference corresponds to a 7% increased risk of having an allergy. Similarly, for a patient with one allergy, each 1-mm increase in head circumference corresponds to a 7% increased risk of having two or more allergies. [Figure 2; OR = 0.93 (95% CI: 0.80–0.99), p = 0.033].

Bottom Line: Smaller head circumference at mid-gestation was associated with increased odds of allergic disease in children aged 1-5 years.A 1 mm smaller head circumference was associated with a 7% increased chance of allergies being later diagnosed, adjusted for gestation (95% CI: 1-14%, p = 0.036).Smaller mid-gestational head circumference is associated with early childhood allergic disease, which suggests that fetal programing of allergic disease occurs before mid-gestation.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Obstetrics, Gynaecology and Neonatology, Charles Perkins Centre Nepean, Sydney Medical School Nepean, The University of Sydney , Penrith, NSW , Australia.

ABSTRACT

Background: Altered fetal growth is known to be associated with allergic disease. Specifically, increased head circumference at birth has been linked to asthma and elevated IgE. However, few studies have examined a link between early fetal anthropometry and allergic disease. The aim of this study was to examine head circumference at mid-gestation in children diagnosed with allergy.

Methods: This was a retrospective cohort study, comprising pregnancies delivered between 10/2006 and 9/2010 at Nepean Hospital, Australia. Exclusion criteria were illegal drug use, alcohol consumption, gestation <35 weeks, and gestational hypertension. Pregnancy data were sourced from the Nepean Obstetric Database. Atopic diseases (asthma, atopic dermatitis, and IgE-mediated food allergy) were assessed by questionnaire at age 1-5 years. Infants from pregnancies with completed questionnaires, who also had a mid-gestation ultrasound scan, were included (N = 121). Multiple logistic regression techniques were used to model head circumference against the development of allergies.

Results: Smaller head circumference at mid-gestation was associated with increased odds of allergic disease in children aged 1-5 years. A 1 mm smaller head circumference was associated with a 7% increased chance of allergies being later diagnosed, adjusted for gestation (95% CI: 1-14%, p = 0.036). Head circumference at mid-gestation was also inversely correlated with the presence of multiple atopic disease.

Conclusion: Smaller mid-gestational head circumference is associated with early childhood allergic disease, which suggests that fetal programing of allergic disease occurs before mid-gestation. This suggests that mediators such as brain-derived neurotrophic factor may be dysregulated early in utero in a milieu, which also predisposes to atopic disease.

No MeSH data available.


Related in: MedlinePlus