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In utero Head Circumference is Associated with Childhood Allergy.

Eviston DP, Minasyan A, Mann KP, Campbell DE, Nanan RK - Front Pediatr (2015)

Bottom Line: Smaller head circumference at mid-gestation was associated with increased odds of allergic disease in children aged 1-5 years.A 1 mm smaller head circumference was associated with a 7% increased chance of allergies being later diagnosed, adjusted for gestation (95% CI: 1-14%, p = 0.036).Smaller mid-gestational head circumference is associated with early childhood allergic disease, which suggests that fetal programing of allergic disease occurs before mid-gestation.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Obstetrics, Gynaecology and Neonatology, Charles Perkins Centre Nepean, Sydney Medical School Nepean, The University of Sydney , Penrith, NSW , Australia.

ABSTRACT

Background: Altered fetal growth is known to be associated with allergic disease. Specifically, increased head circumference at birth has been linked to asthma and elevated IgE. However, few studies have examined a link between early fetal anthropometry and allergic disease. The aim of this study was to examine head circumference at mid-gestation in children diagnosed with allergy.

Methods: This was a retrospective cohort study, comprising pregnancies delivered between 10/2006 and 9/2010 at Nepean Hospital, Australia. Exclusion criteria were illegal drug use, alcohol consumption, gestation <35 weeks, and gestational hypertension. Pregnancy data were sourced from the Nepean Obstetric Database. Atopic diseases (asthma, atopic dermatitis, and IgE-mediated food allergy) were assessed by questionnaire at age 1-5 years. Infants from pregnancies with completed questionnaires, who also had a mid-gestation ultrasound scan, were included (N = 121). Multiple logistic regression techniques were used to model head circumference against the development of allergies.

Results: Smaller head circumference at mid-gestation was associated with increased odds of allergic disease in children aged 1-5 years. A 1 mm smaller head circumference was associated with a 7% increased chance of allergies being later diagnosed, adjusted for gestation (95% CI: 1-14%, p = 0.036). Head circumference at mid-gestation was also inversely correlated with the presence of multiple atopic disease.

Conclusion: Smaller mid-gestational head circumference is associated with early childhood allergic disease, which suggests that fetal programing of allergic disease occurs before mid-gestation. This suggests that mediators such as brain-derived neurotrophic factor may be dysregulated early in utero in a milieu, which also predisposes to atopic disease.

No MeSH data available.


Related in: MedlinePlus

Flow of pregnancies for inclusion.
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Figure 1: Flow of pregnancies for inclusion.

Mentions: During the data collection period, 15,273 singleton pregnancies were delivered at Nepean Hospital, which included 436 pre-eclamptic pregnancies. Based on the exclusion criteria, 184 of these pregnancies were ineligible (Figure 1). The remaining 252 pre-eclamptic pregnancies were matched (1:2) with healthy control pregnancies (504). Eighteen pregnancies were excluded on suspicion of child death, and a total of 738 allergy questionnaires were mailed. Following an attempt at telephone correspondence for non-responders, 227 completed questionnaires were collected. Utilizing Viewpoint software, 121 of these pregnant mothers were found to have a mid-gestation ultrasound scan and were included in the final cohort.


In utero Head Circumference is Associated with Childhood Allergy.

Eviston DP, Minasyan A, Mann KP, Campbell DE, Nanan RK - Front Pediatr (2015)

Flow of pregnancies for inclusion.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4561811&req=5

Figure 1: Flow of pregnancies for inclusion.
Mentions: During the data collection period, 15,273 singleton pregnancies were delivered at Nepean Hospital, which included 436 pre-eclamptic pregnancies. Based on the exclusion criteria, 184 of these pregnancies were ineligible (Figure 1). The remaining 252 pre-eclamptic pregnancies were matched (1:2) with healthy control pregnancies (504). Eighteen pregnancies were excluded on suspicion of child death, and a total of 738 allergy questionnaires were mailed. Following an attempt at telephone correspondence for non-responders, 227 completed questionnaires were collected. Utilizing Viewpoint software, 121 of these pregnant mothers were found to have a mid-gestation ultrasound scan and were included in the final cohort.

Bottom Line: Smaller head circumference at mid-gestation was associated with increased odds of allergic disease in children aged 1-5 years.A 1 mm smaller head circumference was associated with a 7% increased chance of allergies being later diagnosed, adjusted for gestation (95% CI: 1-14%, p = 0.036).Smaller mid-gestational head circumference is associated with early childhood allergic disease, which suggests that fetal programing of allergic disease occurs before mid-gestation.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Obstetrics, Gynaecology and Neonatology, Charles Perkins Centre Nepean, Sydney Medical School Nepean, The University of Sydney , Penrith, NSW , Australia.

ABSTRACT

Background: Altered fetal growth is known to be associated with allergic disease. Specifically, increased head circumference at birth has been linked to asthma and elevated IgE. However, few studies have examined a link between early fetal anthropometry and allergic disease. The aim of this study was to examine head circumference at mid-gestation in children diagnosed with allergy.

Methods: This was a retrospective cohort study, comprising pregnancies delivered between 10/2006 and 9/2010 at Nepean Hospital, Australia. Exclusion criteria were illegal drug use, alcohol consumption, gestation <35 weeks, and gestational hypertension. Pregnancy data were sourced from the Nepean Obstetric Database. Atopic diseases (asthma, atopic dermatitis, and IgE-mediated food allergy) were assessed by questionnaire at age 1-5 years. Infants from pregnancies with completed questionnaires, who also had a mid-gestation ultrasound scan, were included (N = 121). Multiple logistic regression techniques were used to model head circumference against the development of allergies.

Results: Smaller head circumference at mid-gestation was associated with increased odds of allergic disease in children aged 1-5 years. A 1 mm smaller head circumference was associated with a 7% increased chance of allergies being later diagnosed, adjusted for gestation (95% CI: 1-14%, p = 0.036). Head circumference at mid-gestation was also inversely correlated with the presence of multiple atopic disease.

Conclusion: Smaller mid-gestational head circumference is associated with early childhood allergic disease, which suggests that fetal programing of allergic disease occurs before mid-gestation. This suggests that mediators such as brain-derived neurotrophic factor may be dysregulated early in utero in a milieu, which also predisposes to atopic disease.

No MeSH data available.


Related in: MedlinePlus