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Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer.

Fuziwara CS, Kimura ET - Front Med (Lausanne) (2015)

Bottom Line: The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGFβ signaling.Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92.Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo , São Paulo , Brazil.

ABSTRACT
Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGFβ signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the cluster's oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer.

No MeSH data available.


Related in: MedlinePlus

Coordinated transcriptional activation of miR-17-92 by oncogenic signaling pathways synergistically down-regulates important negative regulators of cell growth and proliferation signaling in cancer.
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Figure 1: Coordinated transcriptional activation of miR-17-92 by oncogenic signaling pathways synergistically down-regulates important negative regulators of cell growth and proliferation signaling in cancer.

Mentions: The integration of different datasets from The Cancer Genome Atlas, available from the online cBioportal for Cancer Genomics website, does not show major genetic alterations in MIR17HG in different types of cancer, despite a few cases of genomic amplification (below 10% in some cancers) (12). This indicates that transcriptional (Figure 1) and post-transcriptional processes of miR-17-92 are the key in regulating mature miRNA levels.


Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer.

Fuziwara CS, Kimura ET - Front Med (Lausanne) (2015)

Coordinated transcriptional activation of miR-17-92 by oncogenic signaling pathways synergistically down-regulates important negative regulators of cell growth and proliferation signaling in cancer.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4561802&req=5

Figure 1: Coordinated transcriptional activation of miR-17-92 by oncogenic signaling pathways synergistically down-regulates important negative regulators of cell growth and proliferation signaling in cancer.
Mentions: The integration of different datasets from The Cancer Genome Atlas, available from the online cBioportal for Cancer Genomics website, does not show major genetic alterations in MIR17HG in different types of cancer, despite a few cases of genomic amplification (below 10% in some cancers) (12). This indicates that transcriptional (Figure 1) and post-transcriptional processes of miR-17-92 are the key in regulating mature miRNA levels.

Bottom Line: The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGFβ signaling.Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92.Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo , São Paulo , Brazil.

ABSTRACT
Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGFβ signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the cluster's oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer.

No MeSH data available.


Related in: MedlinePlus