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Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model.

Gao C, Gao Z, Greenway FL, Burton JH, Johnson WD, Keenan MJ, Enright FM, Martin RJ, Chu Y, Zheng J - Nutr Res (2015)

Bottom Line: Oat feeding decreased intestinal fat deposition in N2, daf-16, or daf-16/daf-2 strains (P < .05); and glucose did not affect intestinal fat deposition response.Additional glucose further increased expression 1.5-fold of the 4 genes in N2 (P < .01), decreased the expression of all except cpt-1 in the daf-16 mutant, and reduced mRNA expression of the 4 genes in the daf-16/daf-2 mutant (P < .01).Oat consumption may be a beneficial dietary intervention for reducing fat accumulation, augmenting health span, and improving hyperglycemia-impaired lipid metabolism.

View Article: PubMed Central - PubMed

Affiliation: School of Nutrition and Food Sciences, Louisiana State University, Agricultural Center, Baton Rouge, LA, 70803.

No MeSH data available.


Related in: MedlinePlus

Scatter plot of PCA showing the 2 strong factors in relationship with ckr-1, cpt-1, cpt-2, gcy-8, PPR slope, and IFD.
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Figure 4: Scatter plot of PCA showing the 2 strong factors in relationship with ckr-1, cpt-1, cpt-2, gcy-8, PPR slope, and IFD.

Mentions: Principle component analyses revealed 2 theoretical strong factors that played important roles in the relationship of the components that were tested in this study (Fig. 4, Table 5). Inverse relationship between the IFD and the PPR was detected in N2, daf-16/daf-2, and sir-2.1 mutants. The PPRs were strongly and positively related to the 2 factors in the 3 strains. By contrast, the IFDs were strongly and positively related to the factor 1 in the N2 and the daf-16/daf-2 double mutant, which was negatively associated in the sir-2.1 mutant. The IFD or PPR seemed weakly related to the ckr-1, cpt-1, cpt-2, and gcy-8. The ckr-1, cpt-1, cpt-2, and gcy-8 had strong positive relationships with factor 1 N2, daf-16/daf-2, and sir-2.1 mutants. A loose but positive relationship of the 4 genes with the factor 2 was seen in the daf-16 mutant, whereas the IFD was negatively related to the factor 1 and the PPR did not have any association with either the factors or the 4 genes.


Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model.

Gao C, Gao Z, Greenway FL, Burton JH, Johnson WD, Keenan MJ, Enright FM, Martin RJ, Chu Y, Zheng J - Nutr Res (2015)

Scatter plot of PCA showing the 2 strong factors in relationship with ckr-1, cpt-1, cpt-2, gcy-8, PPR slope, and IFD.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4561582&req=5

Figure 4: Scatter plot of PCA showing the 2 strong factors in relationship with ckr-1, cpt-1, cpt-2, gcy-8, PPR slope, and IFD.
Mentions: Principle component analyses revealed 2 theoretical strong factors that played important roles in the relationship of the components that were tested in this study (Fig. 4, Table 5). Inverse relationship between the IFD and the PPR was detected in N2, daf-16/daf-2, and sir-2.1 mutants. The PPRs were strongly and positively related to the 2 factors in the 3 strains. By contrast, the IFDs were strongly and positively related to the factor 1 in the N2 and the daf-16/daf-2 double mutant, which was negatively associated in the sir-2.1 mutant. The IFD or PPR seemed weakly related to the ckr-1, cpt-1, cpt-2, and gcy-8. The ckr-1, cpt-1, cpt-2, and gcy-8 had strong positive relationships with factor 1 N2, daf-16/daf-2, and sir-2.1 mutants. A loose but positive relationship of the 4 genes with the factor 2 was seen in the daf-16 mutant, whereas the IFD was negatively related to the factor 1 and the PPR did not have any association with either the factors or the 4 genes.

Bottom Line: Oat feeding decreased intestinal fat deposition in N2, daf-16, or daf-16/daf-2 strains (P < .05); and glucose did not affect intestinal fat deposition response.Additional glucose further increased expression 1.5-fold of the 4 genes in N2 (P < .01), decreased the expression of all except cpt-1 in the daf-16 mutant, and reduced mRNA expression of the 4 genes in the daf-16/daf-2 mutant (P < .01).Oat consumption may be a beneficial dietary intervention for reducing fat accumulation, augmenting health span, and improving hyperglycemia-impaired lipid metabolism.

View Article: PubMed Central - PubMed

Affiliation: School of Nutrition and Food Sciences, Louisiana State University, Agricultural Center, Baton Rouge, LA, 70803.

No MeSH data available.


Related in: MedlinePlus